A 70-amino acid hormone that promotes cell growth, proliferation, and survival, primarily produced in the liver in response to growth hormone stimulation.
A drug called CUDC-907, which blocks two cell‑growth pathways (PI3K and HDAC), was shown to shrink endometrial cancer tumors in lab dishes and in mice. The treatment also lowered blood levels of IGF‑1, a hormone linked to growth, suggesting IGF‑1 could be used to track how well the drug works. However, this study is about a cancer therapy, not a supplement or lifestyle tweak you can safely try yourself.
A small 6‑month trial gave children with Fragile X Syndrome metformin (a diabetes drug) and found it helped reduce hyperactivity and improve sleep, but it didn’t change overall behavior scores or cognition. Side effects were mild and IGF‑1 levels dropped a bit, but this wasn’t a focus of the study.
An elderly woman had dangerous low blood sugar because a rare tumor was pumping out too much IGF‑2. She couldn't have surgery, so doctors used radiation to shrink the tumor, gave her steroids and carbs at night, and her blood sugar and heart rhythm got much better.
Stergiopoulos. Georgios M GM; Siontis. Brittany L BL; Ahmed. Safia K SK; Thangaiah. Judith Jebastin...
A rare cancer patient achieved long‑term remission after a combo of drugs that block the IGF‑1 receptor and the growth‑hormone receptor, but this finding is about cancer treatment, not about using IGF‑1 for health or performance in healthy people.
García-Pérez. Isabel I; Rodríguez. Inmaculada I; Rubio. Albert A; Díaz-Serrano....
The paper maps how muscle cells from European sea bass grow and change in a lab dish, tracking many genes including IGF‑1, but it doesn’t give any tips or protocols that people can use for human health or performance.
Harnvoravongchai. Phurt P; Mattiello. Samara Paula SP; Amabat. Achuthan A; C P. Jusail J; Faisal. Sy...
Scientists found that a common gut bacterium, Bifidobacterium longum, can protect tiny worms from harmful Salmonella and Shigella infections by making the gut more acidic and possibly releasing special proteins, while also calming down some of the worm’s immune signals. However, this study doesn’t involve IGF‑1 or give any direct tips for longevity or performance, so it isn’t useful for IGF‑1‑focused biohackers.
The study showed that in rats with a completely severed spinal cord, combining a gene that boosts IGF-1 with stem cell transplants and a drug that activates the KCC2 protein helped some nerve fibers reconnect and improved walking ability, but this was only seen in a very specific injury model and required multiple experimental treatments.
A 32‑year‑old woman without diabetes kept having low blood sugar because a hidden cancer was making too much IGF‑2, which lowered her IGF‑1 and caused hypoglycemia. Doctors found a neuroendocrine tumor that had spread to her liver, but they could not locate where the tumor started. The case shows a rare, dangerous way tumors can cause low blood sugar.
This paper reviews how a high‑fat, low‑carb ketogenic diet and a fasting‑mimicking diet might help treat gastrointestinal cancers, but it does not discuss the IGF‑1 peptide or give any guidance for using IGF‑1 in health‑hacking or longevity protocols.
Gajewska. Joanna J; Chełchowska. Magdalena M; Szamotulska. Katarzyna K; Strucińska. Ma&#...
Data on the interplay between muscle, bone, and adipose tissue metabolism in normal-weight children with Prader-Willi syndrome (PWS) undergoing growth hormone (GH) therapy and dietary interventions are limited. This study aimed to assess the myokine profile and explore the associations between myokines, bone markers, adipokines, and body composition in these patients. The study included 26 children with PWS and 26 age-matched healthy controls. Serum levels of irisin, myostatin (MSTN), fibroblast growth factor-2, insulin-like growth factor-I (IGF-I), IGF-binding protein-2, bone alkaline phosphatase (BALP), osteocalcin (OC), carboxylated OC (Gla-OC), periostin, soluble receptor activator of nuclear factor kappa-B ligand, tartrate-resistant acid phosphatase 5b, leptin/soluble leptin receptor, adiponectin, and proinsulin were measured using immunoenzymatic assays. Children with PWS had significantly lower lean mass (<i>p</i> = 0.047) and a higher fat mass/lean mass ratio (<i>p</i> < 0.001) than controls. Irisin levels were lower in the PWS group (<i>p</i> = 0.031), while MSTN levels were similar between the groups. In patients, irisin positively correlated with BALP (<i>p</i> = 0.025) and negatively correlated with Gla-OC (<i>p</i> = 0.041) and periostin (<i>p</i> = 0.005). MSTN was positively associated with proinsulin (<i>p</i> = 0.001) and negatively associated with lean mass (<i>p</i> = 0.015). OC concentration was lower in the PWS group and correlated positively with lean mass (<i>p</i> = 0.052). Children with PWS exhibit altered myokine, osteokine, and adipokine profiles, as well as differences in body composition. Reduced irisin and osteocalcin levels, along with the negative association between MSTN and lean mass, may impair muscle development and bone metabolism. These imbalances could also contribute to future metabolic disorders in patients with PWS.