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Insulin-like Growth Factor 1, Somatomedin C
A 70-amino acid hormone that promotes cell growth, proliferation, and survival, primarily produced in the liver in response to growth hormone stimulation.
Elhadd. Tarik T; Dabbous. Zeinab Z; Abdelmahmuod. Elabbass A EA; Rohani. Zaina Z; Kailani. Yaman Al...
A small Qatari case series showed that the drug pasireotide, a newer type of somatostatin analogue, can quickly bring down the high IGF‑1 levels that cause acromegaly and even shrink pituitary tumors in most patients, but it can also trigger diabetes‑type side effects.
Koru. Yılmaz Berk YB; Beer. Katharina K; Ruggieri. Angelo Alberto AA; Rodríguez-Cordero....
A study in honey bees shows that messing with gut bacteria early in life (like using antibiotics) can mess up the development of the internal clock and reduce the number of clock‑related brain cells. The same disruption also raises a protein (IGFALS) that holds onto IGF‑1/2, a hormone important for brain growth. This suggests that early gut health can influence IGF signaling and circadian rhythms, which might matter for humans too.
Kushner. Jared A JA; Pandey. Mohit M; Kohli. Sandeep Sonny S SSS
The paper talks about using new sensor devices and AI to measure and understand four aging‑related chemicals in the blood, including IGF‑1. It says that smarter analysis can give a clearer picture of how fast you’re really aging and help spot health risks earlier, but it doesn’t give any new dosing or treatment tips.
Murao. Masanobu M; Hamada. Ryota R; Kanda. Junya J; Kondo. Tadakazu T; Miyasaka. Junsuke J; Asano. T...
In patients who received a bone‑marrow transplant, blood levels of IGF‑1 (a hormone that helps build muscle) dropped and this drop was linked to a quick loss of muscle quality and changes in body water balance. The study suggests that tracking IGF‑1 could warn you when muscle health is deteriorating, but it doesn’t test any specific supplement or training plan.
Johnston. Matthew J MJ; Brown-Borg. Holly M HM
The review looks at mouse studies where the growth hormone/IGF‑1 system is turned off, which makes the animals live longer but can hurt their muscle health. It shows that while less IGF‑1 may boost lifespan, it also speeds up muscle loss (sarcopenia), which is a big factor in aging and frailty. The authors stress that keeping muscles strong—mainly through resistance training—is still the best way to improve healthspan.
Ishida. Tomohisa T; Kawaguchi. Tomohiro T; Ogawa. Yoshikazu Y; Endo. Hidenori H
The study looked at people who had surgery for a hormone‑overproduction tumor (acromegaly) and found that even when lab tests for growth hormone and IGF‑1 didn’t match, most patients stayed stable without extra treatment for many years.
Alhuthil. Raghad R; Alsagheir. Afaf A; Almslam. Maha M; Raed. Jana J; Barakat. Farah F; Murad. Sarah...
This study looked at a rare growth disorder called 3M syndrome in Saudi kids. Most had a genetic mutation, and about half who got growth‑hormone shots grew a bit faster, while the others didn’t benefit. IGF‑1 levels were usually low or normal, and the disease doesn’t affect brain function.
Nazeri. Pantea P; Zarghani. Najmeh Hamzavi NH; Tahmasebinejad. Zhale Z; Dashtkoohi. Mohadese M; Heda...
A study of 122 breastfeeding moms found that the amount of IGF-1 in early breast milk did not affect their kids' brain, language, or motor skills at age three, and higher iodine levels were oddly linked to slightly lower cognitive scores.
Delgado. Diego D; Mercader-Ruiz. Jon J; Marijuán-Pinel. Daniel D; Sánchez. Pello P; Andrad...
Scientists made a stronger, faster‑clotting fibrin gel by adding extra fibrinogen to a platelet‑rich plasma mix. The new gel is stiffer and holds together better, but it breaks down quicker and releases IGF‑1 at the same rate as the regular gel, so it doesn’t give extra IGF‑1 benefits.
Mamidi. Rachna R RR; MacDonald. Kelvin D KD; Spindel. Eliot R ER; McEvoy. Cindy T CT
This paper reviews ways to help the lungs grow in babies born early, like giving mothers steroids before birth, using gentle breathing support after birth, and trying new treatments such as stem cells and the peptide IGF‑1. While IGF‑1 looks promising in experiments, it’s still far from being a safe, proven option for everyday use, especially for adults looking to boost health or performance.
Al-Sayyar. Amnah A; Salvon. Laure L; Haidar. Narjess N; Schult. Paul P; Kassem. Oussama O; Rua. Reja...
The paper explains that the brain’s outer covering (meninges) releases IGF‑1 and other signals that help the cerebellum grow and organize during early development. If these signals are disturbed, the cerebellum can develop abnormally, which may contribute to neurodevelopmental problems.
Najafipour. Farzad F; Jafarpour. Javad J; Bahrami. Amir A; Mobasseri. Majid M; Niafar. Mitra M; Naja...
This study looked at people with a rare hormone disorder called acromegaly who got radiation therapy after surgery. Over 10‑15 years, the treatment steadily lowered their growth hormone and IGF‑1 levels, but most ended up with new hormone deficiencies and some nerve or eye problems. For healthy folks, the findings don’t give a safe or practical way to tweak IGF‑1.
Pugh. Erika A EA; Lee. Gina G; Stokes. Jeffrey E JE; Briggs. Emily E; López-Anuarbe. Mónik...
The study looked at how losing a parent or having parents separate early in life can raise inflammation later on, which is linked to poorer thinking abilities in older adults, especially among White and Hispanic people. IGF‑1 was one of the blood markers used to measure inflammation, but the research didn’t test giving IGF‑1 as a treatment.
Dursunoğlu. Duygu D; Arikoğlu. Hilal H; Kaya. Dudu Erkoç DE; Göktürk. Fat...
Researchers tested a plant compound called juglone on pancreatic cancer cells and found it lowered the levels of the IGF‑1 receptor and other markers that tell cells to grow, which slowed the cancer cells' growth in a lab dish. This effect was seen at micromolar concentrations after 24 hours.
Ceylaner. Betul B; Sahin. Furkan F; Yildiz. Anil A; Tastekin. Didem D; Gok. Ali Fuat Kaan AFK; Bayka...
Researchers measured several IGF‑related proteins in the blood of people with stomach cancer and healthy volunteers. They found that people with cancer had lower IGF‑1 and IGFBP‑5 levels but higher IGFBP‑4 levels, while another protein, PAPP‑A, didn’t change. These differences could help doctors spot stomach cancer earlier, but they don’t tell you how to change your own health routine.
Martínez-Hernández. Rebeca R; Méndez-García. Fernando F FF; Serrano-Somavilla. A...
The study looked at different kinds of pituitary tumors that cause acromegaly, a condition where the body makes too much growth hormone. It found that the amount of IGF‑1 in the blood was similar across tumor types, while prolactin levels varied. Some tumors had fewer receptors that medicines target, which may make those tumors harder to treat.
Gladych-Macioszek. Aleksandra A; Ozegowska. Katarzyna K; Radzicka-Mularczyk. Sandra S; Sibiak. Rafa&...
The review explains that the insulin‑like growth factor (IGF) system helps control cell growth and how the body handles sugar. During pregnancy, especially when the mother has pre‑diabetes or diabetes, the balance of IGFs and their binding proteins can get messed up, which may lead to babies being too large or too small. The authors suggest that fixing these IGF changes could help manage risky pregnancies, but they don’t give concrete ways to do that.
Khalil. Mohamed M; Soliman. Farid F; El-Sabrout. Karim K; Aggag. Sarah S
A study on chickens found that giving them water from an ionizer (which has antioxidant properties) made them drink more, grow bigger, and show higher levels of growth‑related hormones like IGF‑1, while also reducing markers of oxidative stress and DNA damage. However, these results are specific to broiler chicks and may not apply to humans.
Mahfuj. Sarower S; Ferdous. Tamanna T; Babon. Ariful Islam AI; Sarker. Prosonjit Chandra PC; Ahsanul...
The study looked at fish that were heated up to stressful temperatures and found they grew less, had blood and gut problems, and showed lower levels of the growth hormone gene IGF‑1. Adding probiotics to the water or spirulina to the feed helped the fish stay healthier, grow better, and restored IGF‑1 gene activity. The work is done in a fish model, not humans.
Hashmi. Waleed J WJ; Hoggard. Nathan K NK; Kantake. Noriko N; Max-Harry. Ibiagbani M IM; Kane. Jerem...
Removing a specific part of the protein PTHrP in mice makes their growth‑plate cartilage smaller, speeds up the cells' maturation, and lowers the activity of the IGF‑1 system, which is important for bone growth.