An antimicrobial peptide of the cathelicidin family that provides innate immune defense by killing pathogens and modulating inflammation and wound healing.
Acen. Ester Lilian EL; Kateete. David Patrick DP; Worodria. William W; Olum. Ronald R; Joloba. Moses...
The study found that people with active tuberculosis have higher levels of the natural immune peptide LL‑37 in their blood compared to those with latent infection or no infection, and that this difference can help tell the disease states apart, especially distinguishing active TB from no TB.
Ripperda. Thomas T; Yu. Yangsheng Y; Verma. Atul A; Klug. Elizabeth E; Thurman. Michellie M; Reid. S...
Scientists used a new computer method to quickly design short proteins that can stop viruses like Ebola and COVID‑19, similar to a natural human peptide called LL‑37. The engineered peptides showed they can block the virus from entering cells, but the work is still early and not ready for personal use.
Cecotto. Leonardo L; van Kessel. Kok K; Wolfert. Margreet A MA; Vogely. Charles C; van der Wal. Bart...
The study looked at three natural antimicrobial peptides—IDR-1018, CATH-2, and LL‑37—to see if they could both calm inflammation and help immune cells kill Staph aureus. All three reduced inflammatory signals, but only CATH‑2 actually stopped the bacteria from growing. IDR‑1018 made immune cells take up fewer bacteria, yet it didn’t improve killing, and overall the peptides didn’t boost the cells’ natural antibacterial power. The authors suggest mixing peptides or pairing them with antibiotics for better results.
Tran. Hoai Thi Thu HTT; Peterburs. Philipp P; Seibel. Jan J; Abramov-Sommariva. D D; Lamy. Evelyn E
In lab tests, a few herbal mixes used for colds (Imupret, Bronchipret thyme‑ivy, and Bronchipret thyme‑primula) showed the ability to block the virus‑spike protein from binding to the ACE2 receptor and to boost natural antimicrobial peptides like LL‑37 and immune signals such as IFN‑γ. These effects were seen only in cell cultures, not in people, so they are early clues rather than proven treatments.
Pereira. Ana C C ACC; Aguiar. Alana P S APS; Araujo. Leticia M P LMP; Dantas. Larissa O LO; Mayer. M...
The study tested a natural antimicrobial peptide called LL-37, some D‑amino acids, and a common dental antibiotic mix (TAP) on a complex tooth‑root biofilm. Only the combo of LL-37 plus the antibiotics reduced bacterial numbers a little (about 1 log), while each thing alone did not work better than doing nothing.
Yuan. Jiachen J; Gao. Yang Y; Pi. Longquan L; Li. Zhouna Z; Nan. Meilan M; Jin. Zhehu Z; Jin. Chengl...
A new low‑energy, three‑pulse laser treatment (AOPT‑LTL) was tested on mice with LL‑37‑induced rosacea and on 23 people with facial redness. It reduced skin inflammation, blood‑vessel changes, and the key rosacea molecules in mice, and it improved redness and flushing in patients without serious side effects.
Alba. Maryi Lorena Segura MLS; Durán-Rodriguez. Andrea Tatiana AT; Pulido. Luz Mary Salazar LMS...
Researchers tested versions of the natural peptide LL‑37 and found that one variant, called DLL37‑1, can stop harmful bacteria like Staph aureus and Staph epidermidis from forming protective biofilms, and it does so without harming human cells in lab tests.
Golec. Marcin M; Lemieszek. Marta Kinga MK; Dutkiewicz. Jacek J; Milanowski. Janusz J; Barteit. Sand...
This review looks at how the natural peptide LL‑37 in our lungs reacts when we breathe in organic dust, which can cause diseases like asthma, COPD, and hypersensitivity pneumonitis. It finds that LL‑37 levels go up or down depending on the situation, helps fight infections and repair tissue, but can also keep inflammation going and increase mucus. Some early animal work even tried inhaling LL‑37 and saw benefits, but overall the evidence is still early and not ready for everyday use.
The study looked at kids' saliva and found that the natural antimicrobial peptides like LL‑37 and HNP1‑3 might help protect against cavities, but the overall differences weren’t strong enough to change everyday habits yet.
People with a certain lung infection called NTM are more likely to be frail and feel anxious or depressed compared to those with regular bronchiectasis. Their lungs have higher levels of the antimicrobial peptide LL‑37, but their blood levels of LL‑37 are lower, hinting at more local lung inflammation.
Scientists made tiny PLG particles that can slowly release proteins like a growth factor for up to two months, but when they tried the same trick with the peptide LL‑37, the results were inconsistent and hard to reproduce, meaning it’s not a ready‑to‑use method for hobbyists yet.
The study looked at mouth‑immune proteins in college football players who got COVID‑19. After the usual two‑week isolation, their key antimicrobial peptide LL‑37 was back to normal, and overall saliva immunity wasn’t weakened, meaning they’re not at higher risk for other infections when they return to play.
Kim. Jun Young JY; Kwack. Mi Hee MH; Lee. Eun Hye EH; Lee. Weon Ju WJ
The study found that black ginseng water extract makes skin cells that are already inflamed produce even more inflammation signals, activates certain immune pathways, and boosts the skin peptide LL‑37 and oil (sebum) production, which could worsen acne.
The study shows that the peptide LL-37 triggers mast cells through a receptor (MRGPRB2) that isn’t turned off by the usual regulator (GRK2), unlike other triggers like compound 48/80 or substance P. Removing GRK2 in mice reduces some allergy reactions but doesn’t stop the LL-37‑driven response, suggesting LL-37 works via a different pathway.
de Tapia. Lidia L; García-Fojeda. Belén B; Kronqvist. Nina N; Johansson. Jan J; Casals. Cr...
The study shows that a lung protein called SP‑A (and a lab‑made piece of it) can latch onto the human antimicrobial peptide LL‑37, stopping it from hurting lung cells and causing inflammation, while still letting it kill bacteria. This means LL‑37’s harmful side‑effects can be tamed by SP‑A, but the protein isn’t something you can easily take yourself yet.
Scientists made tiny, water‑loving gels that can hold and release the antimicrobial peptide LL‑37 depending on the pH. They showed that the size of the gel particles and how tightly they’re cross‑linked change how much peptide they can carry, and the gels are safe for cells. However, the work is about the material itself, not about how to take LL‑37 for health benefits.
Denardi. Laura Bedin LB; de Arruda Trindade. Priscila P; Weiblen. Carla C; Ianiski. Lara Baccarin LB...
The study tested LL‑37 and other antimicrobial peptides against tough bacteria. LL‑37 did kill the bugs, but only at relatively high doses (40‑160 mg/L), so it’s less powerful than some other peptides tested.
The peptide LL-37, which is part of the body’s natural antimicrobial defenses, was shown in lab dishes and mouse experiments to slow the growth of pancreatic cancer cells. It does this by creating oxidative stress, blocking a cell‑recycling process called autophagy, and shifting the tumor’s immune environment toward anti‑cancer immune cells. However, the work is still early‑stage and has not been tested in people.
Rather. Irfan A IA; Sabir. Jamal S M JSM; Asseri. Amer H AH; Ali. Sajad S
The human peptide LL-37 can kill the drug‑resistant fungus Candida auris in lab tests, especially when mixed with existing antifungal drugs, by breaking its cell membrane and stressing its cells. However, these results are only from test‑tube experiments, not human trials, so they don’t yet translate into a safe DIY treatment.
LL-37 can kill Staph bacteria from chronic wounds, but you need a lot of it (around 90‑130 mg/L) to do so. It also changes some genes that control biofilm and communication even at lower, non‑killing levels, which might help stop the sticky layers bacteria form. However, the amounts needed are high, so it’s not something you can easily use at home right now.