An antimicrobial peptide of the cathelicidin family that provides innate immune defense by killing pathogens and modulating inflammation and wound healing.
Gulati. Sunita S; Schoenhofen. Ian C IC; Lindhout-Djukic. Theresa T; Lewis. Lisa A LA; Moustafa. Ies...
The study shows that gonorrhea bacteria can hide from the immune system by adding a sugar called sialic acid to their surface, which makes them resistant to the natural antimicrobial peptide LL‑37. Researchers found that giving mice similar sugars (CMP‑Kdn or CMP‑Leg5,7Ac2) into the vagina keeps the bacteria vulnerable to LL‑37 and reduces infection, but this only works when LL‑37 is present. The work is still early‑stage and done in mice, so it isn’t a ready‑to‑use treatment for people yet.
Asadi. Arash A; Tavakoli Kareshk. Amir A; Sharifi. Iraj I; Firouzeh. Nima N
In mice, the natural antimicrobial peptide similar to human LL‑37 (called CRAMP) ramps up in skin cells and immune cells when they’re infected with the parasite that causes leishmaniasis, and this rise appears to help protect the animals from the infection.
A study in mice shows that the peptide LL‑37 (called CRAMP in mice) can push a type of immune cell, Th17, to become more suppressive and even die, through a p38 signaling route. This suggests that LL‑37 might actually dampen certain immune functions rather than boost them, especially in a tumor setting.
The study shows that the human antimicrobial peptide LL‑37 can team up with the enzyme RNase 1 to kill E. coli bacteria much more effectively than either alone, even at extremely low (picomolar) doses.
Mücke. Pierre-Alexander PA; Ostrzinski. Anne A; Hammerschmidt. Sven S; Maaß. Sandra S; Bec...
Scientists studied how the pneumonia‑causing bacteria change their protein makeup when hit with two human antimicrobial peptides, hBD3 and LL‑37, and a detergent. Both peptides caused similar shifts, but LL‑37 also triggered extra proteins that tweak the bacterial surface, while the detergent caused its own unique changes.
Janssen. Axel B AB; Doorduijn. Dennis J DJ; Mills. Grant G; Rogers. Malbert R C MRC; Bonten. Marc J...
Researchers grew four strains of Klebsiella bacteria with the antibiotic colistin and watched them become resistant. They found the bacteria used many different genetic tricks to survive, and some of the resistant bugs also became less vulnerable to the human immune peptide LL‑37 and even more harmful in a worm model. The findings mainly warn that using colistin can make bacteria tougher against both drugs and our own defenses, but they don’t give new ways to use LL‑37 for health.
Jenson. Rachel E RE; Baines. Sarah L SL; Howden. Benjamin P BP; Mishra. Nagendra N NN; Farah. Sabrin...
The study found that giving certain beta‑lactam antibiotics (especially cloxacillin) to MRSA bacteria that were resistant to the drug daptomycin can make those bacteria sensitive to daptomycin again. This happens because the bacteria pick up extra changes in a gene called mprF, which also makes them easier for the natural immune peptide LL‑37 to kill.
Wnorowska. Urszula U; Fiedoruk. Krzysztof K; Piktel. Ewelina E; Prasad. Suhanya V SV; Sulik. Magdale...
Scientists are attaching the natural antimicrobial peptide LL‑37 (and similar synthetic versions) to tiny magnetic particles, creating a new kind of nano‑drug that could kill germs, fight cancer cells, and help tissue repair while possibly reducing side effects. The idea looks promising, but it’s still early‑stage research with no clear dosing or home‑use instructions yet.
Gunasekera. Sunithi S; Muhammad. Taj T; Strömstedt. Adam A AA; Rosengren. K Johan KJ; Göra...
Scientists made a version of the natural peptide LL‑37 called KR‑12 into a circular dimer, which makes it much better at killing bacteria and fungi and more resistant to being broken down, but it also becomes more likely to damage human cells.
Moreno-Angarita. Alejandro A; Aragón. Cristian C CC; Tobón. Gabriel J GJ
LL-37 is a natural antimicrobial peptide that also messes with the immune system. In lupus patients it can bind DNA and form complexes that trigger immune cells (pDCs) to release a lot of type I interferon, which fuels the disease. This makes LL-37 a possible marker for lupus activity, but the paper doesn’t give any tips on how to use it for health hacks.
Cavalcante. Paloma Araujo PA; Knight. Cameron G CG; Tan. Yi-Lin YL; Monteiro. Ana Paula Alves APA; B...
In mice, the natural antimicrobial peptide LL‑37 (and its mouse version) helps fight Staph aureus infections in the breast tissue. Mice that can’t make this peptide get worse infections, while giving a synthetic version reduces bacterial entry into cells and even kills the bacteria in lab dishes. The work suggests LL‑37 could be a useful anti‑infection tool, but it’s still early‑stage and only tested in animals.
The study shows that the natural peptide LL‑37, which is part of our immune system, can actually fuel the skin inflammation seen in psoriasis by binding to our own DNA and RNA and turning on immune cells. This means that adding extra LL‑37 (as a supplement or drug) could make psoriasis worse, rather than help.
The study shows that the human antimicrobial peptide LL‑37 can kill the sexually transmitted bacteria Chlamydia trachomatis, but the bacteria release an enzyme (cHtrA) that chops up LL‑37, making it ineffective. Mutated versions of the enzyme can't do this, and the effect is the same across several Chlamydia strains.
Grievink. Hendrika W HW; Jirka. Silvana M G SMG; Woutman. Tess D TD; Schoonakker. Mascha M; Rissmann...
A lab study found that the synthetic peptide omiganan can boost the body's antiviral signaling (type I interferon) when immune cells are triggered by certain viral‑like sensors. The effect seems to come mainly from a special immune cell type called plasmacytoid dendritic cells. While this hints that omiganan could one day help fight viral infections, the research is still early and done only in test‑tube cells.
Cirone. Karina M KM; Lahiri. Priyoshi P; Holani. Ravi R; Tan. Yi Lin YL; Arrazuria. Rakel R; De Buck...
A lab study showed that a synthetic version of the human peptide LL‑37 can help mouse immune cells clear a cattle‑related bacterial infection (MAP) and lower some inflammatory signals. The work is done in cell culture, not in people, and it doesn’t give a dosing plan or safety data for human use.
Aidoukovitch. Alexandra A; Dahl. Sara S; Fält. Felicia F; Nebel. Daniel D; Svensson. Daniel D;...
The study shows that the antimicrobial peptide LL-37 and its precursor hCAP18 are found inside the shed skin cells that float in whole saliva, meaning these cells could help protect the mouth by storing and releasing the peptide.
Scientists found that an enzyme called superoxide dismutase 3 (SOD3) can calm down skin inflammation caused by the antimicrobial peptide LL‑37 and the enzyme KLK‑5. In lab cells and mice, adding SOD3 reduced redness, swelling, and the chemical signals that drive skin irritation.
Al-Farsi. Hissa M HM; Al-Adwani. Salma S; Ahmed. Sultan S; Vogt. Carmen C; Ambikan. Anoop T AT; Lebe...
The study looked at whether bacteria that are resistant to the antibiotic colistin are also tougher against the natural human peptide LL‑37. They found that resistant Klebsiella strains do survive a bit better when LL‑37 is present at high doses, but at normal body‑level concentrations there’s no real difference, and the bacteria’s ability to cause infection stays the same.
Scientists tested a human antimicrobial peptide called LL-37 on airway cells exposed to cigarette‑smoke chemicals. The smoke damaged the cells' barrier and lowered important tight‑junction proteins. Adding LL-37 helped keep the barrier intact and prevented loss of some of those proteins, while standard asthma drugs only partially helped.
Researchers combined two antimicrobial agents—lysostaphin (an enzyme) and the peptide LL-37—inside tiny lipid‑like carriers called niosomes. In lab tests against Staphylococcus aureus, the combined niosomal formulation kept the bacteria from growing for up to three days, while the same amounts of the free agents lost effectiveness after a short time. The niosomes were safe for normal skin cells at the effective doses.