A synthetic decapeptide analog of GnRH that stimulates the pituitary gland to release FSH and LH, aiding in reproductive hormone regulation and fertility treatments.
Sánchez. Manuel L ML; Robinson. Prema P; Italia. Zal Z; Hoang. Tan T; Muñoz. Miguel M; Cov...
The paper reviews how many different peptides, including the hormone GnRH (also called gonadorelin), interact with breast cancer cells. Some peptides can help tumors grow, while others can slow them down. GnRH and drugs that mimic or block it are being studied as possible anti‑cancer tools, but the review doesn’t give specific dosing or home‑use instructions.
A study in zebrafish shows that even tiny amounts of the flame‑retardant chemical TBBPS can mess up the hormone system that controls reproduction, leading to poorer eggs and embryos. These problems show up not only in the fish that were directly exposed but also in their children and grandchildren, even when the chemical is no longer detectable.
Researchers looked at 121 boys with a rare condition where the brain doesn't make enough hormone to start puberty. They found that tiny penis size and undescended testicles are common signs, and that certain blood markers (inhibin B and AMH) can tell early on if the test cells are not working well. Most of the boys had genetic mutations linked to the condition.
Riveros Angel. Marcela M; Loeffler. David D; Charifa. Ahmad A; Sinit. Ryan B RB; Amery. Taylor T; Ce...
A study of men who died with prostate cancer found that treatments that lower testosterone (androgen deprivation therapy) also cut down the amount of a protein called TMPRSS2 in lung cells. TMPRSS2 helps the COVID‑19 virus get into cells, so less of it might mean a lower risk of severe infection. Direct blockers of the androgen receptor lowered TMPRSS2 more than drugs that act on the hormone‑releasing system (like gonadorelin).
Scientists created a gel that holds the hormone GnRH and releases it in bursts when you shine green light on it. This mimics the natural pulsing of the hormone, which is important for certain health effects, especially in brain health. The chemistry is unusual because they attached the hormone to the gel through a part of the molecule that isn’t normally used.
Zhu. Yanyun Y; Li. Mengxian M; Jiang. Xiangyang X; Fu. Dongyuan D; Pan. Zhihao Z; Wu. Zhuoya Z; Han....
A new vaccine that makes the body produce antibodies against GnRH and kisspeptin was tested in male rats and dogs. In rats it sharply lowered testosterone, shrank the testes and stopped sperm production. In dogs the response was mixed, with some showing big drops in testosterone and no sperm, while others changed little.
A large Chinese study looked at how safe and effective ganirelix, a hormone‑blocking peptide, is when used in IVF cycles. Most side effects were mild, serious problems were rare and not linked to the drug, and about one‑third of women ended up with a live birth. No new safety warnings showed up.
In women with PCOS undergoing IVF, using a GnRH agonist (like gonadorelin) to trigger egg release doesn’t have clear predictors of how many eggs will be retrieved per follicle. The only factor that showed any link was a higher antral follicle count (AFC), but its ability to predict a poor response was weak, and body‑mass index or LH levels didn’t help either.
In male mice that lack the brain chemical PACAP, the cells that make the hormone GnRH (which tells the testes to produce testosterone) are fewer, while other hormone‑related cells like kisspeptin increase. This shift also changes the balance of estrogen and androgen receptors in key brain areas, which could explain why these mice have fertility problems.
Researchers tested two experimental GnRH vaccines in male piglets and compared them to a commercial vaccine and surgical castration. Both new vaccines generated strong antibody responses, but they didn't lower testosterone or shrink testicles as much as the commercial product, meaning they were less effective at acting as a contraceptive in this animal model.
Higgi. Adnan A; Melvin. Carys C; Abdelrasheed. Ahmed A; Wilson. Katherine K
Relugolix is a pill that blocks the hormone signals that tell the body to make testosterone. In men with advanced prostate cancer it drops testosterone to very low levels faster than the usual injectable drugs and may cause fewer heart problems. It’s a prescription cancer medication, not something you can safely try on your own, but it shows that oral hormone blockers can work well.
A study of over 2,000 women undergoing frozen embryo transfers found that adding a short course of a GnRH agonist (the peptide gonadorelin) to standard hormone replacement therapy boosted live‑birth rates in women who had a thin uterine lining and had previously been treated for chronic endometritis. The benefit was seen only when the GnRH agonist was combined with hormone therapy, not when hormone therapy was used alone.
Farkas. Imre I; Vastagh. Csaba C; Kalló. Imre I; Kontra. Levente L; Liposits. Zsolt Z
In middle‑aged female mice, the brain cells that make the hormone GnRH (the same hormone in the drug gonadorelin) show big changes: they fire twice as fast, many of their gene messages shift, and they lose some tiny synaptic signals. Some drug responses stay the same, but others, like the effect of a kisspeptin blocker, only appear in older mice. This tells us that the GnRH system starts to remodel well before full reproductive aging.
Rooney. Tess A TA; Lehner. Andreas A; Zyskowski. Justin J; Thompson. Kimberly A KA; Eustace. Ronan R...
Researchers created a new blood test that can accurately measure the hormone deslorelin, then used it to track how the drug is released from a single implant in three goats over a year. The drug peaked quickly in the blood and then stayed at a steady level for months, while fecal hormone tests showed the goats stopped ovulating.
Zhong. Yanyu Y; Kang. Qian Q; Pang. Xin X; Wang. Nan N
Researchers built a simple calculator that uses six lab measurements (like progesterone levels and kidney function) to guess the chance of having a baby after a fresh IVF cycle that uses a GnRH‑antagonist drug regimen. The tool worked fairly well in the data they studied, especially when they tested it on a separate group.
An. Dong-Jun DJ; Shin. Ji-Hee JH; Choe. SeEun S; Lee. Young-Hyeon YH; Jang. Min-Kyung MK; An. Byung-...
Scientists made a virus‑based vaccine for wild boars that also carries a piece of the hormone GnRH. When boars got the vaccine, they made antibodies against GnRH, which lowered their testosterone and caused some shrinkage and damage to the testes. The vaccine worked both when given by mouth and by injection, though the injection was more effective.
Doctors treating pre‑menopausal breast cancer patients with drugs that shut down the ovaries (LHRH agonists) often check blood estradiol levels, but the tests vary a lot and there’s no clear rule on what counts as “incomplete” suppression. While many clinicians do this monitoring, the evidence that it actually improves outcomes is weak, and newer drugs like LHRH antagonists might work better.
Giles. Morgan B MB; Walker. Jennifer J; Schwendeman. Steven P SP
Scientists figured out how to load a hormone‑like peptide (leuprolide) into tiny PLGA plastic beads so that the peptide is released slowly over weeks. By tweaking how many beads they use, how long they soak them, and how much water is inside the beads, they got much higher loading efficiency (up to ~50 % of the peptide ends up inside) and kept the initial burst release low. The method relies on the peptide being absorbed into the polymer rather than just sticking to its surface.
Uddin. Ahm Musleh AM; Kirkwood. Roy N RN; Petrovski. Kiro R KR; Youssef. Souha H SH; Singh. Baljinde...
Scientists tested different ingredients to help a synthetic hormone peptide (buserelin) pass through the vaginal wall. They built a precise lab test to measure how much gets through and found that chitosan, a natural polymer, works best at boosting absorption in pig tissue.
A study of 109 women looking at fertility preservation found that using a GnRH agonist (gonadorelin) alone to trigger egg maturation works just as well as combining it with hCG. Adding hCG didn’t increase the number of mature eggs or change hormone levels, and both methods were safe with no cases of ovarian hyperstimulation.