Zhu. Jie J; Li. Mei M; Yang. Fan F; Cao. Shenglian S; Tang. Haoguo H; Liu. Qiang Q; Xu. Haisen H
The study looked at women with uterine fibroids and compared two treatments: microwave ablation alone versus microwave ablation plus a hormone drug (GnRH agonist). Adding the hormone drug helped shrink the fibroids more, reduced symptoms and pain, and lowered side‑effects and recurrence, but the research is specific to a medical condition and not about general health, longevity, or performance.
Peng. Lixuan L; Tang. Xiaohan X; Tang. Pingping P; Zhou. Cuilan C; Xiang. Yuyan Y; Cao. Wenyu W; Li....
In stressed mice, chronic restraint triggers a specific stress pathway (PERK) in the testicles, leading to poorer sperm and damage to testicular tissue. Giving the drug ISRIB, which blocks this pathway, fixes the tissue, improves sperm quality, and restores hormone balance, but the study does not involve gonadorelin.
Asghari-Moghadam. Morteza M; Behboodi. Hamid-Reza HR; Mehri. Mehran M
Rooster fertility declines with aging, marked by reduced testicular weight, testosterone, semen quality, and antioxidant capacity, leading to lower hatching egg production and economic loss. This study evaluated the physiological effects and optimal inclusion rate of LibidoMax, a phytogenic supplement, on reproductive hormones, semen quality, antioxidant status, immune function, and metabolic biomarkers in aged broiler breeder roosters, using broken-line regression modeling. Twenty roosters (42 weeks old) were randomly assigned to four treatments (0, 100, 200, or 300 mL LibidoMax per 100 kg feed) for 70 days, including 14 days of acclimation. LibidoMax significantly enhanced serum levels of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (P < 0.001). Broken-line regressions identified optimal hormonal plateaus between 182-190 mL/100 kg feed. Semen volume, sperm motility, viability, and concentration improved linearly, with breakpoints around 200 mL/100 kg feed, while sperm abnormality was minimized at ∼179 mL/100 kg feed. Hematological parameters improved with supplementation. Hemoglobin (HGB) and hematocrit (HCT) reached breakpoints at 176.5 and 179.6 mL/100 kg feed, respectively. Red and white blood cell counts (RBC and WBC) plateaued at 178.7-184.1 mL/100 kg feed, indicating enhanced oxygen transport and immune activation. Antioxidant enzymes, including total antioxidant capacity (T-AOC), glutathione peroxidase (GPx), and superoxide dismutase (SOD), peaked at ∼200 mL/100 kg feed, while malondialdehyde (MDA), a lipid peroxidation marker, was minimized at 100-110 mL/100 kg feed, reflecting early saturation of oxidative stress reduction. Lipid profiles were favorably modulated: triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and total cholesterol decreased (breakpoints: 169-178 mL/100 kg feed), whereas high-density lipoprotein (HDL) peaked at 182 mL/100 kg feed. Liver enzymes, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP), were reduced at 170-180 mL/100 kg feed, indicating improved hepatic function. Principal Component Analysis (PCA) confirmed multivariate separation among treatment groups, with LibidoMax positively associated with reproductive, antioxidant, and immune enhancements and negatively with hepatic stress and lipid markers. In conclusion, 180-200 mL/100 kg feed represents the optimal inclusion range of LibidoMax to improve reproductive efficiency, immunity, and systemic health in aged breeder roosters.
Sun. Guangtao G; Peng. Yujing Y; Hu. Chenxu C; Zheng. Yifan Y; Cheng. Yu Y; Qi. Xunzhong X; Jin. Yul...
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Skidmore. Julian Alexandra JA; Mulligan. Brendan Patrick BP; Vaughan. Jane Louise JL
The study tested whether adding the antioxidant enzyme catalase to the storage solution could keep camel embryos alive longer at 4 °C. They found a modest, non‑significant boost in pregnancy rates when embryos were stored for 24–48 hours, but no benefit after 72 hours. The hormone gonadorelin was only mentioned as part of the normal breeding protocol, not as a variable in the experiment.
Sun. Miao M; Liu. Yan Y; Liu. Maolin M; Zeng. Zhongyao Z; Yu. Chengjun C; Han. Rong R; Chen. Long L;...
Researchers found a new deletion in the FGFR1 gene that causes a rare condition where the body doesn’t produce enough hormones for puberty and fertility. The study mainly adds to the list of known genetic mutations linked to this condition and does not suggest any new treatments or ways to improve health.
Sendy. Feras F; Moussaoumay. Naameh N; Hemmings. Robert R
The report describes a single 38‑year‑old woman's unexpected natural pregnancy after a special ovarian‑stimulation protocol that used oral progestin and a hCG trigger. While it shows that pregnancy can still happen during or right after egg retrieval, it does not provide any new information about using the peptide gonadorelin for health, longevity, or performance.
Huang. Qiuyan Q; Hang. Fu F; Mo. LinIing L; Yao. Jun J; Luo. Xiaoqiong X; Zhou. Hong H; Fan. Li L; M...
Oil-based contrast medium in hysterosalpingography has been recommended as an approach to improve fertility in recent years. However, this approach has rarely been applied to patients with unknown recurrent implantation failure (RIF). This randomized clinical trial aimed to assess the effects of intrauterine oil-based contrast infusion on frozen embryo transfer (FET) prognosis and pregnancy outcomes among patients with unknown RIF.
This multicenter prospective randomized clinical trial was conducted between November 2019 and December 2022. A total of 224 patients with unknown RIF were randomized to the intrauterine oil-based medium infusion group or the control group at a 1:1 ratio. The oil-based contrast group was intrauterine infused with ethiodized poppy seed oil at a dose of 5 ml before FET, and the control group underwent only a standard FET. The primary outcome was the live birth rate (LBR). The secondary outcomes were implantation rate, clinical pregnancy rate (CPR), ongoing pregnancy rate (OPR), and early miscarriage rate.
One hundred patients completed intrauterine oil-based medium infusion followed by FET within 120 days. The intention-to-treat analysis demonstrated balanced baseline characteristics between groups. The oil-based medium group exhibited significantly higher CPR (56% vs. 37.4%, rate ratio (RR) 1.498, 95% CI 1.109-2.023, P = 0.007) and implantation rates (median 50% [interquartile range, IQR 0-100%] vs. median 50% [IQR 0-50%], P = 0.010) compared to controls. However, no statistically significant differences were observed in LBR (39% vs. 27.1%, RR 1.439, 95% CI 0.969-2.138, P = 0.069) or OPR (40% vs. 27.1%, RR 1.476, 95% CI 0.997-2.168, P = 0.049), with the latter approaching borderline significance. Subgroup analyses revealed enhanced CPR specifically in RIF patients aged 35-39 years (P = 0.041) and with gonadotropin-releasing hormone agonist (GnRHa) pretreatment hormone replacement therapy (HRT) (GnRHa-HRT) endometrial preparation protocol (P = 0.008). However, no disparities were observed in the LBR and OPR. Within-group comparison of oil-based medium infusion protocols showed that GnRHa-HRT significantly improved reproductive outcomes versus HRT protocols, including LBR (52.2% vs. 26.1%, RR 1.894, 95% CI 1.035-3.466, P = 0.023), CPR (71.7% vs.39.1%, RR 1.983, 95% CI 1.198-3.283, P = 0.002), OPR(P = 0.047), and implantation rate(P = 0.021), which might be attributed to the thickening of the endometrium (P = 0.027).
Infusion with an oil-based medium did not increase the LBR in terms of FET prognosis among patients with unknown RIF. However, compared with HRT, an oil-based contrast agent combined with a GnRHa-HRT FET increased the endometrial thickness and the LBR. These findings suggest synergistic effects of dual interventions, proposing a potential personalized strategy for refractory RIF cases. Further large-scale RCTs and deeper mechanism studies are warranted to validate clinical applicability.
This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University and registered at the Chinese Clinical Trial Registry Center ( http://www.chictr.org.cn/index.html , no ChiCTR1900024273) on July 4th, 2019.
Algul. Sermin S; Erdogan. Busra Alp BA; Karaman. Erbil E; Ozcelik. Oguz O
The study measured two hormones, irisin and kisspeptin, in women at different points of their menstrual cycle and found they rise and fall together in a pattern, with the highest levels in the luteal phase and the lowest during menstruation.
Rafique. Munazzah M; Becker. Christian C; Lewin. Jonathan J; Vashisht. Arvind A; Sarıdoğ...
The efficacy of medical and surgical treatment of endometriosis-associated pain is a source of ongoing controversy. There is a lack of evidence about gonadotropin-releasing hormone agonists (GnRHa) use on long-term pain control, bladder and bowel symptoms for patients having surgery for deep rectovaginal/colorectal endometriosis.
To assess the effect of preoperative GnRHa (pre-GnRHa) use on pain, bowel and bladder symptoms for patients undergoing surgery for deep rectovaginal/colorectal endometriosis.
The study evaluated data from the British Society for Gynaecological Endoscopy database, a large international multicentre prospective cohort of patients who underwent deep rectovaginal/colorectal endometriosis surgery between 2009-2021. We included 9433 patients from 101 accredited endometriosis centres. Multivariable logistic regression analysis was used to evaluate the association between pre-GnRHa use and postoperative pain, bowel and bladder symptoms at different time points, controlling for confounders like patient age, body mass index, smoking status, and hysterectomy.
Rate of cyclical and non-cyclical pelvic and menstrual pain, bowel and bladder symptoms.
The mean age of the patients was 36 years (18-55). Pre-GnRHa use was associated with significant postoperative improvement in premenstrual pain [odds ratio (OR): 0.30, 95% confidence interval (CI): -0.57 - -0.034, <i>P</i>=0.02*], menstrual pain (OR: 0.41/10, 95% CI: -0.7 - -0.13, <i>P</i>=<0.001*), non-cyclical pain (OR: 0.27/10, 95% CI: -0.5 - -0.04, <i>P</i>=0.021*) and lower backache (OR: 0.30, 95% CI: -0.532 - -0.087, <i>P</i>=0.006*) up to 12 months postoperatively. Moreover, bladder pain was significantly reduced in the pre-GnRHa group at 12 months (OR: 0.24, 95% CI: -0.451 - -0.039, <i>P</i>=0.01*). Significant improvements were observed in bowel symptoms including frequent bowel movements (OR: 0.10, 95% CI: -0.194 - -0.012, P=0.02*), incomplete emptying sensation (OR: 0.10, 95% CI: -0.196 - -0.023, <i>P</i>=0.01*), cyclical dyschezia (OR: 0.43, 95% CI: -0.724 - -0.142, <i>P</i>=0.003*) and non-cyclical dyschezia (OR: 0.28, 95% CI: -0.504 - -0.075, <i>P</i>=0.008*) up to 12 months.
Pre-GnRHa use is associated with a significant reduction in postoperative menstrual pain and non-menstrual pain as well as improved bowel and bladder symptoms lasting up to two years. It is also valuable to improve the quality of life for patients undergoing surgery for deep rectovaginal/colorectal endometriosis.
This is the largest prospective international study evaluating pre-GnRHa use in deep rectovaginal/colorectal endometriosis surgery. It provides evidence supporting the role of pre-GnRHa as an adjuvant to surgical treatment, to reduce postoperative pain and improve bowel and bladder function.
Li. Xingchen X; Li. Hong H
The study describes two rare cases of bladder endometriosis, showing that MRI can help diagnose it and that surgery followed by hormone therapy (GnRH agonists and dienogest) prevented short‑term recurrence. This information is specific to a niche medical condition and does not provide actionable guidance for health‑optimizing practices like longevity or performance enhancement.
Xu. Song S; Li. Yuehong Y; Xiang. Hanyu H; Sun. Yan Y; Zhang. Jie J
This study looked at how breathing polluted air while women are undergoing IVF affects the eggs and embryos. It found that higher levels of ozone and fine particles (PM2.5) were linked to fewer fertilized eggs, lower‑quality embryos, and reduced chances of pregnancy and live birth. Certain chemicals in the fluid around the egg seemed to explain part of this damage.
Li. Xi X; Fang. Yuying Y; Song. Jinxi J; Sha. Haichao H; Zhang. Le L; Li. Qi Q
The study shows that tiny plastic particles and certain fluorinated chemicals can harm the reproductive system of tiny aquatic animals by messing up cell signaling pathways, especially those involving protein kinase C and GnRH signals. However, it does not provide any information about using the peptide gonadorelin for health or performance.
Berisha. Bajram B; Pfaffl. Michael W MW; Thaqi. Granit G
The study looked at how two proteins, apelin and its receptor APJ, change their levels in cow ovaries during the hormone surge that triggers ovulation and the early formation of the corpus luteum. It found that apelin rises just before ovulation and stays high afterward, while APJ spikes during the LH peak and stays elevated. The researchers suggest these proteins might help control the final steps of egg release and luteal development in cows.
Matsuzaki. Takashi T; Hamaguchi. Hiroaki H; Ito. Ken R KR; Nakagawa. Ryota R; Nakamura. Hiroya H; It...
The study shows that the receptor for the hormone GnRH is found on certain immune cells (mast cells) in the uterus and fallopian tubes, and when these cells have the receptor they make more signals that help attract cells important for early pregnancy. This effect was seen in lab experiments using a cell line, not in people taking the peptide.
Mallat. George G; Farnsworth. Annabelle A; Honeyball. Florian F; Solomon. Michael M; Grimison. Peter...
We report on the use of combined hormonal therapy with a gonadotropin releasing hormone antagonist and aromatase inhibitor in pelvic aggressive angiomyxoma, with a complete response.
Franco Junior. Jose G JG; Petersen. Claudia G CG; Meziara. Joao Bosco JB; Oliveira. Joao Batista A J...
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Dai. Shuqin S; Wen. Yanling Y; Wu. Xingping X; Wang. Xi X; Yuan. Zhongyu Z; Xu. Fei F; Xie. Xiaoming...
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Kobylarek. Dominik D; Zakryś. Katarzyna K; Gierszewska. Julia J; Pagidela. Bhavana Reddy BR; L...
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Tjahyadi. Dian D; Riyadi. Anthony Sudono AS; Nugrahani. Annisa Dewi AD; Ritonga. Mulyanusa Amarullah...
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