An antimicrobial peptide of the cathelicidin family that provides innate immune defense by killing pathogens and modulating inflammation and wound healing.
Murugan. Ravichandran N RN; Jacob. Binu B; Ahn. Mija M; Hwang. Eunha E; Sohn. Hoik H; Park. Hyo-Nam...
Scientists made very short, custom‑designed peptides (called HDAMPs) that are smaller than the natural human peptide LL‑37 but work even better at killing harmful bacteria and calming inflammation. They added hydrophobic tails and extra positive charges to make the peptides stick to bacterial membranes, kill them by punching holes, and resist being broken down by enzymes. Some of these new peptides work against tough bugs like MRSA and also reduce inflammatory signals, showing promise for future health applications.
Hein-Kristensen. Line L; Knapp. Kolja M KM; Franzyk. Henrik H; Gram. Lone L
The study found that a few antimicrobial peptides become much more powerful against E. coli when mixed with human blood plasma, thanks to the complement system, but this boost doesn’t happen for Staph infections or for peptides that work inside bacteria. This means the body’s own proteins can help certain antibiotics work better, though the effect isn’t seen with all bacteria or drug types.
Youssef. Dima A DA; Peiris. Alan N AN; Kelley. Jim L JL; Grant. William B WB
The paper says vitamin D and curcumin might help the body fight gonorrhea, especially drug‑resistant strains, by boosting the natural antimicrobial peptide LL‑37 and calming down inflammation pathways. While it’s not a proven cure, the combo could support your immune system alongside standard treatment.
Rivas-Santiago. Bruno B; Rivas Santiago. Cesar E CE; Castañeda-Delgado. Julio E JE; León-C...
The study shows that the natural peptide LL‑37 (and similar peptides) can kill TB bacteria in the lab and, when sprayed into the lungs of infected mice a few times a week, cuts the amount of bacteria by 3‑10 times, even for drug‑resistant strains. However, this work is still in early animal testing and isn’t a ready‑to‑use treatment for people.
LL-37, a natural antimicrobial peptide made by our immune cells, can directly knock out flu viruses by breaking their outer membrane, but it works best when it meets the virus before it enters cells. Blood proteins like HDL can dampen its effect, and it doesn’t stop the virus from attaching to cells. It also works well together with other innate immune proteins.
The study found that the antimicrobial peptide LL‑37 is present in the saliva of all children, with higher levels in older kids, girls, and those with mixed or permanent teeth, while kids with lots of cavities have lower levels. This suggests LL‑37 may help protect against tooth decay.
The study found that synthetic cationic lipids (ceragenins) kill oral and respiratory bacteria more effectively than the natural peptide LL‑37, don’t cause resistance, and aren’t toxic to skin cells, while LL‑37 actually boosts gum‑cell growth. For DIY health enthusiasts, these lab‑made compounds look promising as new antibacterial agents, but they’re still experimental and not yet ready for home use.
Crack. L R LR; Jones. L L; Malavige. G N GN; Patel. V V; Ogg. G S GS
The study shows that two natural skin peptides, LL‑37 and hBD‑2, can cut down the amount of chicken‑pox‑shingles virus (VZV) in skin cells and immune cells in lab dishes. Adding these peptides directly lowered virus levels, and blocking them removed the benefit, meaning they’re actively fighting the virus. However, the work is only in cell cultures, so we don’t yet know how to use them safely or effectively in people.
LL-37 is a natural human peptide that can stop bacteria from forming sticky biofilms, which are hard to treat with antibiotics. It works even at low doses and also helps the immune system, making it a promising candidate for new anti‑infection treatments, though it’s still mostly in research stages.
Feng. Xiaorong X; Sambanthamoorthy. Karthik K; Palys. Thomas T; Paranavitana. Chrysanthi C
The human peptide LL-37 and its shorter pieces can quickly kill drug‑resistant Acinetobacter baumannii bacteria in the lab and stop them from forming sticky biofilms, all without harming human cells at the doses that work.
Dixon. Brian M BM; Barker. Tyler T; McKinnon. Toni T; Cuomo. John J; Frei. Balz B; Borregaard. Niels...
The study found that in healthy middle‑aged adults, blood levels of the antimicrobial peptide LL‑37 rise together with vitamin D levels, but only up to about 32 ng/ml of 25‑hydroxyvitamin D. Above that vitamin D amount, the link disappears, suggesting a ceiling effect. This hints that keeping vitamin D in the moderate range may naturally boost LL‑37, which helps fight infections.
Scientists figured out a way to make the human antimicrobial peptide LL-37 in ordinary bacteria by attaching it to a removable tag, then cutting it off to get the natural form, which still kills E. coli and gives about 2.4 mg of peptide per liter of culture.
McCrudden. Maelíosa T C MT; Orr. David F DF; Yu. Yang Y; Coulter. Wilson A WA; Manning. Gwen G;...
LL-37, a natural antimicrobial peptide, is found in gum fluid both in healthy people and those with gum disease, but in diseased gums it gets broken down quickly by bacterial enzymes, especially when the bad bacteria Porphyromonas gingivalis is present. This means simply adding LL-37 to the mouth won’t work well unless it’s protected or modified.
Love. John F JF; Tran-Winkler. Hien J HJ; Wessels. Michael R MR
The study shows that the human peptide LL‑37, which rises when you take vitamin D, can actually make strep throat bacteria (GAS) tougher for your own cells to kill by turning on the bacteria’s own attack tools. So, boosting LL‑37 (for example with high vitamin D) might unintentionally help the bacteria avoid being destroyed by mouth cells and immune cells.
Nagant. C C; Pitts. B B; Nazmi. K K; Vandenbranden. M M; Bolscher. J G JG; Stewart. P S PS; Dehaye....
Researchers broke down the human peptide LL‑37 into shorter pieces and found that a 25‑amino‑acid fragment called LL7‑31 can stop Pseudomonas aeruginosa from forming biofilms and even break down existing ones, while being less harmful to human cells than the full‑length peptide.
Al-Mutairi. Nawaf N; El Eassa. Bayoumi B; Nair. Vasanthy V
People with plaque psoriasis and related health problems tend to have lower blood vitamin D and higher levels of the immune peptide LL‑37. This pattern might help explain why psoriasis patients often develop other diseases.
Rosen. Graciela G; Sela. Michael N MN; Bachrach. Gilad G
The study shows that the human peptide LL‑37 can kill the gum‑disease bacterium Treponema denticola, and that the bacteria’s own protease (dentilisin) doesn’t actually shield it because saliva blocks that protease. The bacteria’s surface protein (MSP) grabs LL‑37, which helps the peptide work before it gets cut. This means LL‑37 stays active in the mouth and could be useful for oral health support.
Choi. Ka-Yee KY; Chow. Leola N Y LN; Mookherjee. Neeloffer N
LL-37 and similar antimicrobial peptides do more than kill germs – they also tweak the immune system and inflammation. Scientists are learning how these tiny proteins talk to immune cells, affect signaling pathways, and could be used to treat inflammatory diseases, but most of this knowledge comes from lab studies, not real‑world dosing guidelines.
A year‑long study gave people with weak immune systems or many colds 4,000 IU of vitamin D3 each day and found they got fewer respiratory symptoms and used fewer antibiotics compared to a placebo group.
The paper explains that our mouths produce many natural antibiotics called antimicrobial peptides (AMPs), like LL‑37, which help fight gum disease. In periodontal disease some AMPs go up while others go down, and the natural levels in saliva are often too low to be fully effective, meaning boosting them could improve oral health and reduce inflammation.