Use search to browse all 100+ peptides
Pralmorelin, Growth Hormone Releasing Peptide-2, KP-102
A synthetic hexapeptide that mimics ghrelin to stimulate growth hormone release from the pituitary gland via GHS receptors.
Ohara. Emi E; Tokuyama. Hirotake H; Kitamoto. Takumi T; Kitahara. Aya A; Hayashi. Aiko A; Hayashi. H...
In obese people, the hormone boost you get from the peptide GHRP‑2 is blunted, but after they lose a lot of weight through sleeve‑gastrectomy surgery, the GHRP‑2 test shows a much stronger growth‑hormone response.
Peroni. Cibele N CN; Hayashida. Cesar Y CY; Nascimento. Nancy N; Longuini. Viviane C VC; Toledo. Rod...
In a mouse model that can’t release growth hormone normally because its growth‑hormone‑releasing hormone (GHRH) receptors are broken, a single injection of the peptide GHRP‑2 still caused a measurable rise in growth‑hormone levels. The effect was smaller than in normal mice but clearly above baseline, showing that GHRP‑2 can trigger hormone release through a different pathway that doesn’t need GHRH.
Kano. Toshiko T; Sugihara. Hitoshi H; Sudo. Mariko M; Nagao. Mototsugu M; Harada. Taro T; Ishizaki....
This small study shows that giving a single IV dose of the peptide GHRP‑2 can raise cortisol levels in a way that closely matches the traditional insulin tolerance test (ITT), which is the gold‑standard for checking adrenal (HPA‑axis) health. A cortisol level of about 13‑14 µg/dL after GHRP‑2 reliably flags adrenal failure, suggesting the peptide could be a simpler way to assess this system, though the research is still early and done in a clinical setting.
Teramoto. Shinichiro S; Tahara. Shigeyuki S; Hattori. Yujiro Y; Kondo. Akihide A; Morita. Akio A
In older adults with non‑cancerous pituitary tumors, the growth‑hormone‑releasing peptide‑2 (GHRP‑2) test safely triggers a GH surge, and the size of that surge is linked to how well the adrenal glands are working. A peak GH level around 8 ng/mL can help spot hidden adrenal problems before surgery.
Semenistaya. Ekaterina E; Zvereva. Irina I; Thomas. Andreas A; Thevis. Mario M; Krotov. Grigory G; R...
The study looked at how long different growth‑hormone‑releasing peptides (GHRPs) and their breakdown products show up in urine after a single nasal dose. It found that the original peptide often disappears quickly, but smaller fragments (metabolites) can stick around for 1‑2 days, depending on the specific peptide. This matters for anyone using these compounds because it tells you how long they can be detected in a drug test and gives clues about how the body processes them.
Kinoshita. Yasuyuki Y; Tominaga. Atsushi A; Usui. Satoshi S; Arita. Kazunori K; Sakoguchi. Tetsuhiko...
In a Japanese study of adults with pituitary tumors, researchers compared three ways to test growth hormone (GH) production: the classic insulin tolerance test (ITT), an arginine test, and a GHRP‑2 test. They found that the GHRP‑2 test caused a much bigger GH spike than the ITT, while the arginine test gave a smaller spike. Both the arginine and GHRP‑2 tests were good at identifying people with severe GH deficiency, meaning they could replace the more risky ITT for diagnosis.
Hu. Rui R; Wang. Zhisheng Z; Peng. Quanhui Q; Zou. Huawei H; Wang. Hongze H; Yu. Xiaoqiang X; Jing....
In a study on yaks that were not growing well, giving the peptide GHRP‑2 helped them gain weight faster, raised their blood growth hormone and IGF‑1 levels, and made their muscle fibers bigger by turning on the body’s protein‑building pathways.
Hu. Xiaoyu X; Xu. Beihua B; Zhou. Ziniu Z
Researchers made a version of the growth‑hormone‑releasing peptide GHRP‑2 that’s attached to a small PEG molecule, and they showed in rats that this PEG‑linked peptide stays active longer in the blood without losing much of its effect. The study is pre‑clinical, so it hints at a way to make GHRP‑2 work for a longer time, but it doesn’t give direct dosing advice for people yet.
Veldhuis. Johannes D JD; Erickson. Dana D; Wigham. Jean J; Weist. Sue S; Miles. John M JM; Bowers. C...
In older men and women, giving a burst of growth hormone normally shuts down the body's own GH release, but this suppression can be lessened if you add a sex hormone (testosterone for men, estradiol for women) and a GH‑releasing peptide like GHRP‑2. The study shows that both the type of secretagogue and the presence of sex steroids help the body bounce back and release more GH, and men tend to get a bigger rebound than women.
Norman. Catalina C; Miles. John J; Bowers. Cyril Y CY; Veldhuis. Johannes D JD
In older men, giving the GH‑releasing peptide GHRP‑2 together with testosterone or higher estradiol levels boosts the natural, pulse‑like spikes of growth hormone (GH). Leaner men (lower BMI) also see a stronger GH response to GHRP‑2. The study shows that hormone balance and body composition shape how well GHRP‑2 works.
Iranmanesh. Ali A; Bowers. Cyril Y CY; Veldhuis. Johannes D JD
The study shows that the peptide GHRP‑2, often used by biohackers to boost growth hormone, also triggers a noticeable rise in cortisol, the body’s stress hormone. This cortisol spike is bigger in older men and is linked to higher belly fat and lower levels of the male hormone DHT. Baseline cortisol doesn’t change with different testosterone‑related treatments, but the type of secretagogue (like GHRP‑2) matters a lot for how high cortisol gets.
Hayakawa. Tomoaki T; Kitamura. Tetsuhiro T; Tamada. Daisuke D; Mukai. Kosuke K; Hayashi. Reiko R; Ta...
The study looked at whether a ghrelin‑like peptide test (GHRP‑2) can replace the insulin tolerance test (ITT) for checking how well the adrenal glands work. Overall, the two tests were moderately linked, but the GHRP‑2 test missed many cases and wasn’t reliable for most people. However, in men who don’t have a pituitary tumor, the GHRP‑2 test was almost as accurate as the ITT.
Kageyama. Kazunori K; Nigawara. Takeshi T; Sakihara. Satoru S; Takayasu. Shinobu S; Terui. Ken K; Mo...
The study shows that giving the peptide GHRP‑2 can trigger the same ACTH (adrenal‑stimulating hormone) response as the traditional insulin tolerance test (ITT) in people with pituitary problems. If the body reacts to GHRP‑2, it likely has a functional adrenal axis; if not, it probably doesn’t. This means GHRP‑2 could be used as a safer, simpler way to check adrenal health instead of the risky ITT.
Paulo. Remberto C RC; Cosma. Mihaela M; Soares-Welch. Cacia C; Bailey. Joy N JN; Mielke. Kristi L KL...
In healthy young men, the ability of GHRP‑2 (and other GH‑releasing combos) to raise growth hormone drops as body‑fat (BMI) goes up, but only when testosterone levels are normal. When testosterone is experimentally lowered, the BMI effect disappears, though overall GH release is still weaker. In short, being lean and having normal sex‑hormone levels makes GHRP‑2 work best.
Van den Berghe. Greet G; Baxter. Robert C RC; Weekers. Frank F; Wouters. Pieter P; Bowers. Cyril Y C...
In very sick men, giving the growth‑hormone‑releasing peptide GHRP‑2 alone jump‑started GH production, but only when it was combined with thyroid‑stimulating hormone (TRH) and a gonadotropin‑releasing hormone (GnRH) did it also revive thyroid and sex‑hormone systems and improve some metabolic markers. The triple combo was far more effective than GHRP‑2 by itself, though the study was done in ICU patients, not healthy volunteers.
Pinyot. Armand A; Nikolovski. Zoran Z; Bosch. Jaume J; Such-Sanmartín. Gerard G; Kageyama. Shin...
The paper describes a simple urine test that can spot growth‑hormone‑releasing peptides like GHRP‑2 by seeing if they knock a radioactive tag off the GHS‑R1a receptor. The test works in a dose‑dependent way and can detect GHRP‑2 for about 4.5 hours after it’s taken.
Perboni. Simona S; Bowers. Cyril C; Kojima. Shinya S; Asakawa. Akihiro A; Inui. Akio A
In a mouse study, giving the peptide GHRP‑2 together with the chemotherapy drug 5‑fluorouracil helped cancer‑bearing mice eat more and feel less anorexic. The combo also hinted at a slightly longer survival, though the difference wasn't statistically solid.
Sheriff. Sulaiman S; Joshi. Rashika R; Friend. Lou Ann LA; James. J Howard JH; Balasubramaniam. Ambi...
In rats with severe burns, a short peptide called GHRP-2 (a ghrelin mimetic) reduced inflammation and the activity of muscle‑breaking enzymes, leading to less loss of muscle protein. The peptide was delivered continuously for a day via a tiny pump, and it blunted the rise in markers that normally drive muscle wasting after injury.
Fukuda. Izumi I; Hizuka. Naomi N; Muraoka. Toko T; Ichihara. Atsuhiro A
Adult growth hormone deficiency (AGHD) causes bad body composition, bad lipids, insulin resistance, and lower quality of life. In Japan, a GHRP-2 stimulation test is used to diagnose AGHD, with a peak GH level below 9 µg/L indicating severe deficiency. GH replacement starts low (3 µg/kg/day) and is adjusted based on symptoms and IGF‑1 levels, but it’s still unclear if it lowers death risk.
Furuta. Sadayoshi S; Shimada. Osafumi O; Doi. Naomi N; Ukai. Kiyoharu K; Nakagawa. Terutake T; Watan...
GHRP-2 (also called KP-102) is a short peptide that strongly stimulates growth hormone release by acting on the brain and pituitary. In animal tests, doses that boost GH did not cause noticeable problems in the nervous system, heart, lungs, kidneys, or blood, with only tiny, short‑lived effects on gut muscle at very high amounts. This suggests the peptide is relatively safe at the levels needed to raise GH.