A synthetic dipeptide that modulates immune function, promotes chromatin remodeling, and exhibits anti-aging effects by enhancing gene expression and immune responses.
Kuznik. B I BI; Kolesnichenko. L R LR; Kliuchereva. N N NN; Pinelis. Iu I IuI; Ryzhak. G A GA; Khama...
In people with type‑1 diabetes, blood tends to clot too much and break down clots too slowly, a problem that isn’t fixed by usual diabetes meds. Giving the short peptide Vilon (Lys‑Glu) lowered these clot‑related abnormalities, sometimes almost completely, though the benefit was smaller in older patients with severe disease.
Scientists found two short protein pieces (peptides) from Antarctic krill that can block two enzymes linked to high blood pressure and high blood sugar. In lab tests, these peptides stopped the enzymes at fairly low concentrations, suggesting they might help manage hypertension and diabetes if they work the same way in the body.
Khavinson. V K VK; Timofeeva. N M NM; Malinin. V V VV; Egorova. V V VV; Nikitina. A A AA
Giving rats a small peptide called vilon (Lys‑Glu) by mouth boosted the activity of several digestive enzymes, especially in the older 11‑month‑old rats, making their gut function more like younger animals.
Kuznik. B I BI; Isakova. N V NV; Kliuchereva. N N NN; Maleeva. N V NV; Pinelis. I S IS
A small study gave the peptide Vilon to older people with type I diabetes and saw better blood clotting balance, a lower insulin need, and a more normal immune profile. The changes suggest Vilon might help manage diabetes‑related blood and immune issues, but the research is limited and doesn’t give clear dosing guidance.
Koplik. E V EV; Meshcheriakov. A F AF; Pertsov. S S SS; Umriukhin. P E PE; Sudakov. K V KV; Khavinso...
In a rat study, giving the synthetic peptide vilon by injection helped the animals handle emotional stress better, kept their adrenal glands from swelling, stopped the thymus from shrinking, and raised blood albumin levels, while also lowering stress‑related brain activity markers.
Khavinson. V Kh VKh; Kuznik. B I BI; Ryzhak. G A GA
The paper reviews long‑term clinical work on several peptide bioregulators, including Vilon, saying they may help prevent age‑related diseases and act as “geroprotectors,” but it doesn’t give clear dosing or protocol details.
Sevostianova. N N NN; Linkova. N S NS; Polyakova. V O VO; Chervyakova. N A NA; Kostylev. A V AV; Dur...
The study looked at two small protein fragments, called AB-O and R-1, and found they can boost certain immune‑cell markers in lab‑grown human and rat thymus cells. Both increased a protein called CD5, which is linked to T‑cell development. R‑1 was better than AB-O at pushing immature cells to become mature helper (CD4) and killer (CD8) T‑cells, hinting it might act as an immune‑boosting and anti‑allergy agent.
Сhervyakova. N A NA; Linkova. N S NS; Chalisova. N I NI; Koncevaya. E A EA; Trofimova. S V SV;...
The study shows that the peptide Vilon can help keep the spleen’s immune cells healthier as we age by lowering cell death and boosting helper T‑cells, while other short peptides have related but different effects on B‑cells and cell growth. However, the research is basic and doesn’t give dosage or human‑specific guidance, so it’s more a hint than a ready‑to‑use protocol for biohackers.
Lin'kova. N S NS; Polyakova. V O VO; Trofimov. A V AV; Kvetnoy. I M IM; Khavinson. V Kh VKh
A lab study found that one specific peptide, called AB-9, helped old immune cells from the thymus grow and avoid dying when they were grown in a dish. The other two peptides tested didn’t show this effect. This suggests AB-9 might have anti‑aging effects on the thymus, but the work was only done in cell culture, not in people.
Ivanov. S D SD; Khavinson. V Kh VKh; Malinin. V V VV; Kovan'ko. E G EG; Iamshanov. V A VA; Kondrat'e...
In rats that were repeatedly exposed to low doses of radiation and mercury, a peptide called vilon helped bring white blood cell counts back to normal and seemed to lower death rates over the next year, but the study was done only in animals under toxic conditions, not in healthy people.
Khavinson. V K VK; Linkova. N S NS; Ashapkin. V V VV; Shilovsky. G A GA; Borushko. N V NV; Petukhov....
The KE peptide (Lys‑Glu, also called vilon) was shown in lab-grown human stem cells to boost a longevity‑related protein called SIRT1 and lower two DNA‑repair proteins (PARP1 and PARP2) that tend to rise as cells age. The peptide appears to bind specific DNA sequences in the gene promoters, which may explain how it changes gene activity. These results suggest a possible anti‑aging effect, but they are limited to cell‑culture experiments and don’t tell us how to use the peptide in people.
Kudriavtseva. T A TA; Zaĭchenko. I N IN; Efremov. O M OM; Baĭramov. A A AA; Grigor'ev. E...
In old male rats, a small daily dose of the dipeptide Vilon (50 µg per rat) boosted sexual activity and changed several brain and blood hormones linked to sexual health, especially lowering the age‑related rise in prolactin. The effects seem to come from a mix of hormone and neurotransmitter changes rather than one single factor.
Ivko. O M OM; Drobintseva. A O AO; Leont'eva. D O DO; Kvetnoy. I M IM; Polyakova. V O VO; Linkova. N...
A lab study found that two peptides, epitalon (AEDG) and vilon (KE), can improve mitochondrial markers and lower a ribosomal protein that rises with cell aging in pineal and thymus cells grown in dishes. The effects were modest and only shown in cell cultures, not in people, and no dosing or safety info was provided.
Khavinson. V Kh VKh; Tarnovskaya. S I SI; Lin'kova. N S NS; Chervyakova. N A NA; Nichik. T E TE; Ela...
A short two‑amino‑acid peptide made of lysine and glutamic acid (Lys‑Glu) helped spleen cells grow in a lab dish, while the same two amino acids mixed together actually slowed growth. The peptide sticks to DNA more strongly than the separate amino acids, likely because the peptide bond lets it fit into the DNA’s minor groove better, which may explain its growth‑boosting effect.
Pliss. G B GB; Mel'nikov. A S AS; Malinin. V V VV; Khavinson. V Kh VKh
In a mouse study, giving a tiny amount of the peptide vilon (Lys‑Glu) lowered the chance of getting colon‑type tumors from a cancer‑causing chemical, dropping tumor rates from 60% to about 14%, and also reduced early‑stage kidney changes linked to cancer.
Ias'kevich. L S LS; Krutilina. N I NI; Kostetskaia. T V TV; Ryzhak. G A GA; Khavinson. V Kh VKh
A small study looked at adding the peptide Vilon to the usual chemo‑radiation treatment for older people with colon or rectal cancer. The researchers say patients who got Vilon lived longer (about two years), had fewer post‑surgery problems, and felt better overall, but the report is very preliminary and lacks details on dose or safety.
In rats, a small amount of radiation speeds up aging in the thymus and spleen. Giving the synthetic dipeptide vilon (made of lysine and glutamic acid) partly slowed down this aging effect. The authors think vilon could be worth studying for anti‑aging purposes, but the evidence is still very early and only in animals.
Pinelis. I S IS; Pinelis. Y I YI; Kuznik. B I BI; Iordanishvili. A K AK; Vasiliev. M A MA
The paper says that peptide drugs like vilon, which mimic parts of the immune system, may help treat gum disease and other mouth‑related problems, especially in older people. It talks about how these peptides could protect cells and reduce inflammation, but it doesn’t give clear dosing instructions or strong clinical trial results.
Khavinson. V K VK; Anisimov. V N VN; Zavarzina. N Y NY; Zabezhinskii. M A MA; Zimina. O A OA; Popovi...
In a mouse study, a peptide called vilon (a short Lys-Glu chain) given under the skin to middle‑aged female mice made them more active, improved endurance, lowered their body temperature, extended their lifespan and reduced tumor formation, without obvious side effects. It didn’t change reproductive cycles or antioxidant markers.
Kozina. L S LS; Arutiunian. A V AV; Stvolinskiĭ. S L SL; Khavinson. V Kh VKh
In lab tests, the short peptide vilon (along with pinealon, vesugen, and epitalon) didn’t act as a direct antioxidant, but it helped protect human lipoproteins from damage and made red blood cells tougher against swelling. It also raised steady levels of reactive oxygen inside cells while surprisingly keeping more nerve cells alive, hinting it might influence cell death pathways if taken in a living organism.