Completed
NA
INTERVENTIONAL
NCT02689414
A Study of Remote Ischaemic Preconditioning in Patients With Atherosclerosis Undergoing Vascular Surgery
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
The purpose of this study is to evaluate the effect of preoperative remote ischaemic preconditioning (RIPC) on organ damage and the functional characteristics of arteries in patients undergoing vascular surgery. In addition, we investigate the connection between RIPC and changes in the functional characteristics of arteries and low molecular weight metabolites.
Interventions
Name:
Remote ischaemic preconditioning
Type:
PROCEDURE
Description:
Ischaemia is achieved by using a blood pressure cuff on an arm by raising the cuff pressure to 200 mm Hg or to a value that is 20 mm Hg greater than the patient's systolic blood pressure - if the patient's systolic blood pressure is more than 180 mm Hg. The intervention starts simultaneously with the induction of anaesthesia or a few minutes earlier.
Name:
Control to RIPC
Type:
PROCEDURE
Description:
Venous pressure is achieved by using a blood pressure cuff on an arm by raising the cuff pressure to 10-20 mm Hg. The intervention starts simultaneously with the induction of anaesthesia or a few minutes earlier.
Primary Outcomes
Measure:
Carotide-femoral pulse velocity
TimeFrame:
24 h
Description:
Measured with Sphygmocor XCEL
* baseline characteristics are measured before surgery
* measuring is repeated 24 h after surgery
Measure:
Augmentation index
TimeFrame:
24 h
Description:
Measured with Sphygmocor XCEL
* baseline characteristics are measured before surgery
* measuring is repeated 24 h after surgery
Trial Information
NCT ID
NCT02689414
Status
Completed
Study Type
INTERVENTIONAL
Phases
NA
Sponsor
Tartu University Hospital
Last Updated
December 15, 2025