A neuropeptide that induces delta sleep, reduces stress, modulates hormone release, and exhibits antioxidant effects in various physiological processes.
Frederiksen. S O SO; Ekman. R R; Gottfries. C G CG; Widerlöv. E E; Jonsson. S S
A study looked at brain tissue from people with schizophrenia and found that several brain chemicals, including DSIP, were lower in a part of the brain called the temporal cortex, but not in the hypothalamus. The drop in DSIP was only a trend, not a clear cut difference, and medication didn’t explain the changes.
Nilsson. O O; Wängberg. B B; Wigander. A A; Lundmark. K K; Dahlström. A A; Ahlman. H H; Bj...
Researchers found that a peptide called delta sleep‑inducing peptide (DSIP) or something very similar is naturally made and stored inside certain tumor cells from the adrenal gland, and these cells can release it into their surroundings.
el Kafi. B B; Cespuglio. R R; Leger. L L; Marinesco. S S; Jouvet. M M
In a rat study, scientists injected three sleep‑related peptides directly into a tiny brain area called the nucleus raphe dorsalis. They found that CLIP and VIP could boost certain sleep stages when placed right there, but DSIP did nothing at any dose.
Wikkelsö. C C; Ekman. R R; Westergren. I I; Johansson. B B
The study measured several brain chemicals (including DSIP) in the spinal fluid of people with normal‑pressure hydrocephalus (NPH), Alzheimer’s, and multi‑infarct dementia. It found that DSIP and some other peptides were lower in NPH patients, rose after they got a shunt surgery, and that these changes matched clinical improvement. However, peptide levels didn’t track how severe the dementia was.
Edvinsson. L L; Minthon. L L; Ekman. R R; Gustafson. L L
A study of brain fluid from people with Alzheimer's disease (AD) and a type of frontotemporal dementia (FTD) found that several brain chemicals are lower than normal. The most striking drop was in a peptide called delta sleep‑inducing peptide (DSIP), but only in the AD group. The same drop was not seen in the FTD group, and another peptide (CRF) was lower only in FTD.
Träskman-Bendz. L L; Ekman. R R; Regnéll. G G; Ohman. R R
The study measured several brain chemicals, including delta‑sleep‑inducing peptide (DSIP), in the spinal fluid of people who had tried to kill themselves. It found that people with major depression had lower levels of DSIP (and some other peptides) compared to other patients, and that DSIP levels were linked to other stress‑related hormones. No direct link was found between DSIP and serotonin breakdown products, and the research did not test any treatments.
Scientists discovered that mouse pituitary cells make a tiny, sugar‑attached version of a peptide similar to delta sleep‑inducing peptide (DSIP). It comes from larger precursor proteins, gets processed, and is released from the cells, but it isn’t exactly the same as the DSIP found in rabbits.
In a lab study with rat pituitary cells, researchers found that a sleep‑related molecule called prostaglandin D2 (PGD2) can block the hormone‑releasing signal (CRF) that normally makes the pituitary release ACTH, a stress‑related hormone. The effect was seen at very low concentrations and was similar to another sleep factor, DSIP.
Scientists examined pig pituitary and adrenal glands to see how different extraction methods pull out a sleep‑related peptide called DSIP. They found that water with a protease inhibitor gave the most signal in the pituitary, while acid extraction with a purification step matched synthetic DSIP in the adrenal gland. The work is mostly about lab techniques and doesn’t tell you how to use DSIP in people.
In kidney patients on dialysis, giving recombinant erythropoietin (EPO) raised their blood hemoglobin and made them feel better, but the study didn't find any changes in several brain‑related peptides measured in the blood.
Yon. L L; Feuilloley. M M; Charnay. Y Y; Vaudry. H H
Scientists mapped where a sleep‑related peptide called delta sleep‑inducing peptide (DSIP) is found in the brain and pituitary of a frog. They saw it in many brain areas and even inside hormone‑producing cells, but when they added the peptide to frog pituitary or adrenal tissue, it didn’t change the release of stress hormones like ACTH, cortisol or aldosterone.
The study shows a fast lab trick using a microwave to stick a peptide called delta‑sleep‑inducing peptide (DSIP) onto tiny gold beads, then stick those beads onto brain slices so you can see exactly where the peptide binds. It works, but it’s a method for scientists, not a new health tip for everyday use.
Scientists showed that an enzyme called carboxypeptidase Y can cut proteins that contain a special form of the amino acid isoaspartate, releasing tiny pieces (isoaspartyl dipeptides). The amount of these pieces released depends on the surrounding amino acids, and they only appear when isoaspartate is present, not with normal aspartate or asparagine. This method can be used to spot isoaspartate in proteins that have been exposed to high pH, which is a sign of protein aging.
Bjartell. A A; Ekman. R R; Hedenbro. J J; Sjölund. K K; Sundler. F F
Scientists found that a peptide called delta sleep‑inducing peptide (DSIP) or a very similar molecule is naturally present in human gut cells that release hormones like gastrin, CCK, secretin, and PYY. The human gut had the most of this peptide compared to pig or rat guts, and the chemical looks the same as a known fragment of DSIP.
Nakamura. A A; Nakashima. M M; Sugao. T T; Kanemoto. H H; Fukumura. Y Y; Shiomi. H H
A study in mice and rats found that giving delta-sleep‑inducing peptide (DSIP) directly into the brain reduces pain responses, but this effect only works when the peptide is delivered straight into the brain's fluid spaces and is blocked by an opioid blocker. It doesn't work when given into the spinal cord, and it doesn't help animals already tolerant to morphine.
A study in eight cats showed that giving delta sleep‑inducing peptide (DSIP) under the skin boosted the amount of deep, slow‑wave sleep on the EEG, but it didn’t significantly change how long the cats stayed awake, how quickly they fell asleep, or how much REM sleep they got.
Noteborn. H P HP; Graf. M V MV; Ernst. A A; Schoenenberger. G A GA; Weusten. J A JA; Ebels. I I; Sal...
Scientists found that a sleep‑related peptide called DSIP naturally occurs in sheep pineal glands and can stick to larger proteins without forming a chemical bond. They used various lab techniques to separate and identify the peptide and showed it can exist both on its own and attached to big protein molecules.
Ernst. A A; Cramer. H H; Strubel. D D; Kuntzmann. F F; Schoenenberger. G A GA
The study measured two forms of a brain peptide called DSIP in spinal fluid. Healthy older people had higher levels of the regular form, while people with Alzheimer's, other dementias, Parkinson's, vascular disease, or hydrocephalus had lower levels. The phosphorylated version didn't change with disease.
Minthon. L L; Edvinsson. L L; Ekman. R R; Gustafson. L L
A study measured three brain chemicals in the spinal fluid of people with two kinds of dementia. It found that the peptide called DSIP was lower in Alzheimer's disease but a bit higher in frontotemporal dementia. Other chemicals (somatostatin and neuropeptide Y) also changed differently between the two diseases.
Bjartell. A A; Castro. M G MG; Ekman. R R; Sundler. F F; Widerlöv. E E; Loh. Y P YP
In mice, a peptide called delta sleep‑inducing peptide (DSIP) is found together with thyroid‑stimulating hormone in the front part of the pituitary gland. Giving synthetic DSIP reduces the release of ACTH, a stress hormone, and the hormones CRF and AVP can lower the amount of DSIP that the pituitary releases. The study is basic animal research and does not give direct advice for people.