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DSIP

Emideltide, DSIP nonapeptide, Delta sleep-inducing peptide

A neuropeptide that induces delta sleep, reduces stress, modulates hormone release, and exhibits antioxidant effects in various physiological processes.

Quick Stats
Studies 458
Trials 82
Formula C35H48N10O15
Overview Studies 458 Clinical Trials 82
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pubmed 2014

[Using deltalicin for the treatment of patients with diabetic retinopathy].

Kresiun. N V NV; Godlevskiĭ. L S LS

The characteristics of visual evoked potential (VEP) have been investigated in a group of 15 healthy volunteers (aged 31.7 ± 3.6 years) and 30 insulin-dependent patients (aged 32.1 ± 4.0 years) with diabetes mellitus, among which 15 patients suffered from diabetic retinopathy and 15 patients had no retinopathy. An increase in the latent period along with reduction of the VEP amplitude after photostress action upon the macular part of retina have been observed in patients with diabetes, these effects were more pronounced in the subgroup with retinopathy. The restoration of VEP characteristics in 73.5 ± 3.3 s from the moment of photostress was observed in the control group, while this index in both subgroups of diabetic patients without and with retinopathy was 88.7 ± 5.9 and 137.2 ± 11.3 s, respectively. Treatment with deltalicin (daily dose of 0.0003 g of delta sleep-inducing peptide intranasally for two months) decreased the latent period and led to less pronounced depression of VEP amplitude in patients with diabetic retinopathy, and reduced the period of restoration of VEP characteristics to 95.1 ± 6.8 s.

pubmed 2007

[Sleep and anesthesia--Part 1, Recent findings in research].

Kushikata. Tetsuya T; Yoshida. Hitoshi H; Yasuda. Tadanobu T; Tose. Ryuji R; Hirota. Kazuyoshi K; Ma...

The abstract talks about how modern neuroscience links sleep and anesthesia, suggesting they share some brain mechanisms. It notes that studying sleep could help us understand anesthesia better and that anesthesia‑related sleep problems need fixing for better patient quality of life.

pubmed 2005

[Individuality of emotional stress].

Sudakov. K V KV

The author postulates a need of individual evaluation of experimental data characterizing emotional stress. In typical conflict situations inducing emotional stress, there are animals resistant or predisposed to disturbance of different physiological functions. Prognostic criteria of individual resistance of animals to stressors are presented. Stress resistance depends in large on neuromediators and neuropeptides content, in particular Substance P, a peptide responsible for delta-sleep, and beta-endorphin, in brain structures and peripheral tissues. It is emphasized that individual estimation of clinical indices of emotional stress is needed.

pubmed 2002

[Pharmacological efficacy of delta sleep-inducing peptide in experimental acute pancreatitis].

Bondarenko. T I TI; Kalmykova. Iu A IuA; Shustanova. T A TA; Mikhaleva. I I II

The development of experimental acute pancreatitis (EOP) in rats is accompanied by (i) intensification of the lipid peroxidation (LPO) process and the accumulation of malonic dialdehyde (MDA, an LPO product) in the tissues of pancreas, liver, and kidney and in the blood serum, (ii) destabilization of membranes and reduction of the osmotic resistance of erythrocytes (ORE), (iii) increase in the concentration of extracorpuscular hemoglobin (ECH) and medium-molecular-weight molecules (MWM) in the blood serum, and intensification of protein autolysis in tissues. Preliminary triple intraperitoneal administration of a delta-sleep-inducing peptide (DSIP) in a dose of 12 micrograms/100 g body weight to the test rats with EOP stabilized LPO, improved the erythrocyte membrane structure, reduced the MDA level in tissues and blood serum, increased ORE, reduced the ECH and MWM level in the blood, and decreased the protein autolysis rate in tissues.

pubmed 1997

[Effects of delta-sleep-inducing peptide during ischemic injury of the rat brain].

Shandra. A A AA; Godlevskiĭ. L S LS; Brusentsov. A I AI; Vast'ianov. R S RS; Karliuga. V A VA;...

An anti-ischemic effect of the delta-sleep-inducing peptide (DSIP) was found in rats. The DSIP effect was more obvious than that of the MK-801. The data obtained is discussed considering a possible use of the DSIP for brain stroke prophylaxis.

pubmed 1996

[The neuromediator mechanism of the additive action of the delta sleep-inducing peptide in experimental audiogenic epilepsy caused by hypokinesia].

Mendzheritskiĭ. A M AM; Uskova. N I NI; Lysenko. A V AV; Revinskiĭ. Iu V IuV

The DSIP influence on the rat cortex, thalamic and hypothalamic adrenaline, noradrenaline, DOPA, dopamine and serotonin level under normal, hypokinetic stress condition (1 h in duration) and experimental audiogenic epilepsy was studied. It was found, that a single intraperitoneal DSIP injection (12 microns/100 g body weigh, 1 h before placing the animals into the stress condition) prevented spontaneous epileptic activity development due to creation of optimal ratio between monoamines in brain structures.

pubmed 1996

[A rotational syndrome induced by administration of the delta sleep-inducing peptide into the reticular portion of the rat substantia nigra].

Shandra. A A AA; Godlevskiĭ. L S LS; Vast'ianov. R S RS; Zaporozhchenko. M B MB; Ibragim. M M;...

Injecting the peptide DSIP into a specific brain area of rats caused them to spin in circles, and this effect could be blocked by naloxone or made stronger by haloperidol. The study is purely experimental and done in rats, with no clear link to human health or practical use.

pubmed 1995

[Changes in the content of substance P, beta-endorphin and corticosterone in the hypothalamus and blood of rats with emotional stress after the administration of the delta sleep-inducing peptide].

Sudakov. K V KV; Coghlan. J P JP; Kotov. A V AV; Salieva. R M RM; Polyntsev. Iu V IuV; Koplik. E V E...

The aim of this study was to investigate time-related changes in substance P (SP) beta-endorphin (BE), and corticosteron (CORT) levels induced by DSIP administration in rats subjected to emotional stress. Experiments were carried out in male Wistar and August rats with different resistance to emotional stress. At night rats were tied by their tails to the backside of the special cages. These stress-inducing procedure was repeated for 12 hours daily in the course of 5 days. SP and BE immunoreactivity in the hypothalamus and plasma and blood CORT level were determined radioimmunologically. Six groups of animals were formed: 1. control animals; 2. stressed animals; 3. rats which received DSIP in a dose of 60 nmol/kg one hour before decapitation; 3. rats to which DSIP was injected 24 hours before decapitation; 5. stressed rats to which DSIP was injected one hour before decapitation during the 5th exposure to stress; 6. stressed rats to which DSIP was injected 12 hours before the 5th exposure to stress, i.e. 24 hours before decapitation. Our experiments showed that DSIP administration induced marked changes in SP, BE, and CORT levels in the hypothalamus and blood plasma. This suggests that long-term stress-coping effects of DSIP in underlied by considerable changes in the content of other oligopeptides and hormones. Evidently, DSIP triggers these processes inducing a cascade of interrelated molecular reactions which are different in Wistar and August rats. It seems likely that DSIP administration stimulates the mechanisms of resistance in August rats to a lesser extent than in Wistar rats.

pubmed 1997

[The correction of amphetamine action by the delta sleep-inducing peptide].

Dovedova. E L EL; Monakov. M Iu MIu

Effects of "delta-sleep inducing peptide" administration (60 micrograms/kg) to rats on the background of amphetamine action (2.5 mg/kg during 3 weeks) were studied. Activities of the enzymes of neurotransmitter turnover as well as the contents of biogenic amines in structures of motor cortex and caudate nucleus were investigated. Normalizing action of the peptide on the studied indices was found. It reflected the correction of the increased activity of dopaminergic and serotoninergic systems elevated as a result of amphetamine action. The suggestion was made that reconstruction of the interactions of neurotransmitter systems in brain providing adaptive behavior in animals was the main mechanism of delta-sleep inducing peptide's action.

pubmed 1994

[The delta sleep-inducing peptide as a modulator of synaptic ultrastructure].

Mendzheritskiĭ. A M AM; Mikhaleva. I I II; Matsionis. A E AE; Pavilaĭtite. P E PE

Results of morphometric study of ultrastructure of axosomatic and axospinous synapses of rat sensomotor neocortex after DSIP administration and in hypoxia showed that the peptide administration resulted in multidirectional changes in these type contacts in intact animals. This, apparently, is connected with their different functional specialization. Preliminary DSIP administration prevented changes, appearing in hypoxia in most of the parameters studied both in axosomatic and axospinous synapses.

pubmed 1992

[The frequency composition of the brain electrical activity in rats after the use of the delta-sleep peptide and its analogs].

Vorob'ev. V V VV; Shibaev. N V NV; Prudchenko. I A IA; Mikhaleva. I I II

Frequency spectra of brain electrograms in the course of 1 h after peripheral and central administration of the delta-sleep peptide (DSIP) or two its analogues were studied in freely moving rats. In autumn series of experiments carried out on 18 animals was revealed the phase action of DSIP being manifested in initial (up to 20 min after the injection) suppression of fast (20-26 Hz) oscillations in electrocorticograms and their augmentation in subsequent intervals. Under the identical conditions analogues of DSIP induced the effects characteristic for different phases of DSIP action. In spring-summer series of experiments carried out in 6 animals was revealed a significant increase of the delta-waves in electrical activity of the Putamen after intraperitoneal injection of DSIP and its first analogue. Under the conditions of intraventricular injection DSIP induced stable augmentation of oscillations in a diapason of 14-16 Hz in the neocortex, and its analogues induced similar changes in a nearby frequency diapason of 9.6-11 Hz.

pubmed 1992

[The effect of the delta sleep-inducing peptide on seizure activity].

SHandra. A A AA; Godlevskiĭ. L S LS; Mazarati. A M AM; Oleshko. A A AA; Mikhaleva. I I II

The delta-sleep-inducing peptide (DSIP) suppressed seizure activity in the cat cortical strychnine-induced seizure foci. The DSIP delayed development of corazol kindling in rats, prevented seizure induced with bicucullin and other agents in mice. The DSIP effect was shown to be realised through the action upon reticular black substance. The DSIP seems to take part in endogenous control of the brain excitability.

pubmed 1990

[ Anticataleptic effect of delta sleep-inducing peptide and its action on brain monoamine oxidase in rats genetically predisposed to catalepsy].

Voĭtenko. N N NN; Kolpakov. V G VG; Alekhina. T A TA

Rats with genetic susceptibility to catalepsy (GC strain) were compared with Wistar rats (W). After an intraperitoneal administration of 120 micrograms/100 g delta sleep-inducing peptide (DSIP) in GC rats the duration of cataleptic freezing was shortened (13.8 +/- 9.5 sec against 27.2 +/- 7.5 sec in control). MAO-B activity decreased due to DSIP administration both in GC and W rats. It is hypothesized that the DSIP effect MAO-B in GC rats may correct the lost MAO-A function in deamination of dopamine, a common MAO-A and MAO-B substrate, and the dopaminergic neurotransmission in catalepsy.