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HN, S14G-Humanin
A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.
Li. Muqin M; Liu. Zhihua Z; Cao. Xueqin X; Xiao. Wenjin W; Wang. Shurong S; Zhao. Chengyuan C; Zhao....
A lab study found that a special form of the peptide Humanin can stop sugar‑induced aging of blood‑vessel cells by keeping a protective protein called SIRT6 active and lowering harmful reactive oxygen species. This was shown in human vein cells grown in high‑glucose conditions, not in people.
Peña Agudelo. Jorge A JA; Pidre. Matías L ML; Garcia Fallit. Matias M; Pérez Küp...
The study found that the mitochondrial peptide humanin can actually help brain cancer cells (glioblastoma) survive chemotherapy and become more aggressive, meaning taking humanin might not be safe for people with cancer or at high risk of it.
Coradduzza. Donatella D; Cruciani. Sara S; Sibono. Leonardo L; Tedde. Alessandro A; Zinellu. Angelo...
The study found that the natural peptide Humanin is lower in men with early prostate problems and prostate cancer compared to those with benign enlargement, suggesting it could be a useful blood marker for spotting disease early, but it doesn’t tell you how to use Humanin as a supplement or therapy.
Ha. Cuong P CP; Hua. Tuyen N M TNM; Vo. Vu T A VTA; Om. Jiyeon J; Han. Sangwon S; Cha. Seung-Kuy SK;...
The study found that the mitochondrial peptide humanin can make brain cancer (glioblastoma) grow faster by turning on a specific cell‑surface pathway (integrin αV‑TGFβ). Humanin was higher in tumor tissue, helped cancer cells stick, move and invade, and made mice with brain tumors die sooner. Blocking the TGFβ receptor reduced these effects.
Wang. Jinyuan J; Wen. Wen W; Liu. Liu L; He. Junhui J; Deng. Renhe R; Su. Mingxuan M; Zhao. Shuhua S...
In a mouse study, two tiny proteins made in mitochondria – a humanin analogue called HNG and another called MOTS‑c – helped keep the testes working after the animals got a chemotherapy drug that normally damages fertility. The researchers saw that these peptides protected sperm‑producing cells and changed the activity of several genes linked to male reproductive health.
Gruschus. James M JM; Morris. Daniel L DL; Tjandra. Nico N
The study looked at how the genetic code for several tiny proteins made in mitochondria has changed over evolution. It found that humanin and one other peptide, SHLP6, are highly conserved, meaning they probably have important roles in the body, while many of the other related peptides don’t show this pattern. This suggests humanin is a real, functional molecule worth paying attention to, but the paper doesn’t give any dosing or usage tips.
Xia. Yi Y; Zhang. Han-Yong HY; Ma. Sha S; Zhou. Fang F
The study found that a tiny protein called humanin is naturally present in rat ovaries, especially in young rats, and its levels drop as the rats get older, hinting it might play a role in how ovaries age.
Alqahtani. Saad Misfer SM; Al-Kuraishy. Hayder M HM; Al-Gareeb. Ali I AI; Alexiou. Athanasios A; Faw...
Humanin is a tiny protein made by mitochondria that appears to protect brain cells from the damage that causes Alzheimer’s, mainly by fighting oxidative stress and the toxic effects of amyloid‑beta. As we age, the brain makes less of it, which may contribute to memory loss, while blood levels sometimes rise as a possible emergency response, though studies disagree. The review highlights these mixed findings but suggests Humanin could be a useful target for future anti‑aging or brain‑health strategies.
Onat. Elif E; Önalan. Ebru E; Özdem. Berna B; Kavak Balgetir. Merve M; Kuloğlu. Tunc...
Giving the peptide humanin to rats before they get a chemically‑induced heart attack helped protect their hearts – the damage markers in blood went down, the tissue looked less damaged, and the Notch signaling proteins went up, especially a week later.
Chouksey. Shivika S; Shukla. Satya Nidhi SN; Dubey. Amita A; Soni. Yogesh Y; Mandal. Sanju S; Choura...
Researchers found the mitochondrial peptide humanin in goat testes and sperm, especially in the neck and head of the sperm cells. Its levels were higher during the rainy season, which also showed better sperm count, movement, and mitochondrial health. This suggests humanin might be linked to sperm quality, but the study is in goats and doesn’t give direct advice for humans.
Waldmann. Dominique D; Lu. Yu Y; Cortada. Maurizio M; Bodmer. Daniel D; Levano Huaman. Soledad S
Researchers found that two tiny proteins made by mitochondria, humanin and MOTS‑c, can shield inner‑ear hair cells from damage caused by the antibiotic gentamicin in lab‑grown ear tissue. Humanin works by dialing down a cell‑growth signal (AKT), while MOTS‑c turns up an energy‑sensing signal (AMPK). This suggests these peptides might help protect hearing, but the work is still early and done only in mouse ear samples, not people.
Wu. Yunlong Y; Zhang. Hui H; Guan. Lingbo L; Jia. Xiangli X; Wang. Mei M
A modified humanin peptide (S14G‑humanin) reduced lung damage and inflammation in mice given a bacterial toxin, lowering swelling, immune cell buildup, oxidative stress, and blocking the NF‑κB inflammation pathway.
Atreya. Mihir R MR; Piraino. Giovanna G; Cvijanovich. Natalie Z NZ; Fitzgerald. Julie C JC; Weiss. S...
This study looked at a tiny protein called humanin in the blood of kids with severe sepsis. They found that humanin levels were higher early on and linked to kidney injury and worse outcomes, but it didn’t clearly predict the worst form of organ failure after accounting for age and illness severity. The results hint that humanin could become a useful marker or treatment target, but more research is needed before it can be used in everyday health hacks.
Aksu. Feyza F; Akkoc. Ramazan Fazil RF; Savur. Ezgi E; Çelik. Celal C
In rats, breathing formaldehyde lowered a longevity‑related protein called humanin, but giving the antioxidant N‑acetylcysteine (NAC) brought humanin levels back up toward normal. The same protective effect was seen for another protein, endostatin.
Hekım. Munevver Gizem MG; Ozcan. Sibel S; Yur. Mesut M; Yıldırım. Nilgun N;...
The study found that people with early‑stage breast cancer had higher levels of the mitochondrial peptide humanin in their blood compared to healthy women, suggesting it could help flag cancer early, but the test isn’t yet available for personal use.
Huang. Jin J; Liu. Yumeng Y; Zou. Liping L; Zhu. Changhong C; Xia. Wei W
In rats, a modified version of the natural peptide humanin (called HNG) helped protect ovaries from damage caused by the chemotherapy drug cyclophosphamide. It kept hormone levels normal, saved egg‑containing follicles, and lowered cell death by cutting oxidative stress. Similar protective effects were seen in ovarian cells grown in the lab.
Li. Yang Y; Li. Zhuozhuo Z; Ren. Yuanyuan Y; Lei. Ying Y; Yang. Silong S; Shi. Yuqi Y; Peng. Han H;...
This review explains that tiny proteins made by mitochondria, like humanin, help control cell death, inflammation, and oxidative stress. Their levels drop as we age and when heart disease is present, so they could serve as early warning signals and maybe even be used as treatments, but the paper doesn’t give specific ways to use them yet.
Wagner. Monica L ML; Ammann. Allison A; Piraino. Giovanna G; Wolfe. Vivian V; O'Connor. Michael M; L...
In a mouse study, giving a lab-made version of the mitochondrial peptide humanin (humanin‑G) helped animals survive severe blood loss better, improved their blood pressure, lung health, and heart mitochondria, and it worked even when a key energy‑regulating protein (AMPKα1) was missing. The peptide’s natural levels also rose during shock, suggesting the body uses it as a defense.
Asil. Hatice H; Demiryürek. Abdullah Tuncay AT; Düzen. Irfan Veysel IV; Büyükcel...
The study looked at diabetic heart‑failure patients taking SGLT2‑inhibitor drugs (empagliflozin or dapagliflozin) and measured two mitochondria‑derived peptides, humanin and MOTS‑c. The drugs didn’t change humanin levels but did raise MOTS‑c, lowered harmful nitrosative stress, and shifted markers away from a cell‑death process called ferroptosis. This suggests the heart benefits of these drugs aren’t due to humanin.
Bilgin. Batuhan B; Hekim. Munevver Gizem MG; Bulut. Ferah F; Kelestemur. Muhammed Mirac MM; Adam. Mu...
In mice, giving the mitochondrial peptide humanin (about 4 mg per kg body weight by injection) for two weeks reduced pain from diabetes‑related, chemotherapy‑related, and nerve‑injury models. It worked by boosting antioxidant enzymes and anti‑inflammatory signals while lowering oxidative damage and pro‑inflammatory cytokines.