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HN, S14G-Humanin
A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.
Arakawa. Tsutomu T; Niikura. Takako T; Kita. Yoshiko Y
The study shows that the C8A‑humanin peptide stays stable and disordered at body temperature, just like the strong S14G‑humanin, but it still doesn’t protect neurons. This means that simply being stable isn’t enough for the peptide to work; the exact amino‑acid changes matter for activity.
Qin. Qing Q; Mehta. Hemal H; Yen. Kelvin K; Navarrete. Gerardo G; Brandhorst. Sebastian S; Wan. Junx...
In older mice, giving a humanin‑like peptide for many months lowered the amount of scar tissue and cell death in the heart, likely by turning on a protective Akt/GSK‑3β signaling pathway. The treated mice had more heart muscle cells relative to fibroblasts, and less collagen buildup, which are signs of a healthier heart as they age.
Hirano. Atsushi A; Shiraki. Kentaro K; Niikura. Takako T; Arakawa. Tsutomu T; Kita. Yoshiko Y
The study shows that the peptide Humanin can stick to negatively‑charged fat bubbles (liposomes) and fold into a specific sheet shape, which seems important for its brain‑protecting action. A super‑active version (S14G) is much more stable in plain water, which may help it work better when it finally meets the liposome. Even a version that doesn’t work (S7A) still binds the liposome, so the membrane interaction itself is a key part of how Humanin works.
Arakawa. Tsutomu T; Niikura. Takako T; Kita. Yoshiko Y
The study found that a tiny change in the Humanin peptide (switching serine to glycine at position 14) makes it far more stable at body temperature and dramatically boosts its brain‑protective effect, while another change (serine to alanine at position 7) does the opposite.
Wu. Mei-Na MN; Zhou. Li-Wei LW; Wang. Zhao-Jun ZJ; Han. Wei-Na WN; Zhang. Jun J; Liu. Xiao-Jie XJ; T...
A lab study found that a humanin‑based peptide called Colivelin, when directly injected into the rat brain, stopped the memory‑damaging effects of an Alzheimer‑linked protein, kept brain cells’ communication strong, and prevented harmful calcium buildup. This shows the peptide can protect brain function in animals, but the method isn’t ready for people yet.
Yin. Rong R; Yin. Kai K; Guo. ZhiQiang Z; Zhang. ZhiQiang Z; Chen. LiPin L; Cao. Li L; Li. YuanMin Y...
A study in Alzheimer’s‑model mice found that Colivelin, a synthetic version of the human peptide humanin, helped the mice remember better, lowered the buildup of harmful amyloid proteins, and reduced brain inflammation and cell death. The benefits seemed to come from blocking a stress‑related pathway (p38). However, the work was done only in mice, so we don’t yet know if it works or is safe in people.
Matsuoka. Masaaki M; Hashimoto. Yuichi Y
Humanin is a tiny protein that has been shown in mouse studies to protect brain cells from the damage that leads to Alzheimer’s disease. It works by attaching to a specific set of receptors on the cell surface, which helps stop cell death and keep neurons functioning. While the results are promising, they’re still in animal models, so we don’t yet know the right dose or safety for people.
Jia. Yue Y; Ohanyan. Aikoui A; Lue. Yan-He YH; Swerdloff. Ronald S RS; Liu. Peter Y PY; Cohen. Pinch...
Humanin, a tiny protein made by our cells, was shown to protect male sperm‑producing cells from the damage caused by chemotherapy drugs in mouse studies. Several modified versions of humanin worked similarly, acting mainly through a cell‑surface receptor and a signaling pathway called STAT3. This suggests humanin could someday help preserve male fertility during cancer treatment, but we still need human trials and dosage info before anyone can safely use it themselves.
Hayashi. Masaaki M; Tajima. Hirohisa H; Hashimoto. Yuichi Y; Matsuoka. Masaaki M
A skin‑derived protein called CLSP, which is similar to the peptide Humanin, was given to mice and helped reverse memory problems caused by a drug that blocks brain receptors. It works when injected into the body because it can cross the blood‑brain barrier and is more powerful than Humanin in lab tests. This is still an early animal study, so it isn’t ready for human use yet, but it points to a possible new memory‑supporting peptide.
Wu. Hongbing H; Li. Jianxu J; Zhang. Qizhi Q; Yan. Xiluan X; Guo. Liangran L; Gao. Xiaoling X; Qiu....
Scientists created tiny, brain‑targeting particles called cubosomes and coated them with a small, non‑immune peptide (Odorranalectin) to help carry a humanin variant into the brain through the nose. In rats with Alzheimer‑like symptoms, this nose‑to‑brain delivery boosted brain levels of the peptide and improved memory test performance compared to regular particles.
Bachar. Adi R AR; Scheffer. Lea L; Schroeder. Andreas S AS; Nakamura. Hiromi K HK; Cobb. Laura J LJ;...
Humanin, a tiny 24‑amino‑acid peptide, is naturally found in the lining of human blood vessels and can protect those cells from damage caused by oxidized “bad” cholesterol. In lab tests, adding a small amount of humanin cut oxidative stress and cell death in endothelial cells by about half, hinting it could help keep arteries healthier. However, the work is only in cell cultures, so real‑world dosing and effectiveness are still unknown.
Matsuoka. Masaaki M
Humanin is a tiny protein that has been shown in lab and mouse studies to protect brain cells from the damage that leads to Alzheimer’s disease, even blocking the harmful effects of amyloid‑beta. While the data are promising, it’s still early‑stage research and not yet ready for personal use.
Matsuoka. Masaaki M; Hashimoto. Yuichi Y; Aiso. Sadakazu S; Nishimoto. Ikuo I
Humanin is a tiny protein that can protect brain cells from dying, and scientists have made even stronger versions called HNG17 and colivelin that work at incredibly low doses in lab dishes and mouse models of Alzheimer’s and ALS. While the results look promising, they’re still early‑stage and haven’t been tested in people, so there’s no clear dosing or safety guide for everyday use yet.
Hashimoto. Yuichi Y; Kurita. Megumi M; Aiso. Sadakazu S; Nishimoto. Ikuo I; Matsuoka. Masaaki M
Humanin is a tiny protein that can protect brain cells from dying, and it does this by hooking onto a specific group of cell‑surface receptors (CNTFR, WSX‑1 and gp130) that then turn on protective signaling inside the cell. The study shows exactly which receptors are needed for this effect, confirming that humanin works through a cytokine‑type pathway rather than some unknown mechanism.
Xu. Xingshun X; Chua. Chu C CC; Gao. Jinping J; Hamdy. Ronald C RC; Chua. Balvin H L BH
In mice, a powerful form of the tiny protein humanin (called HNG) given before or shortly after a stroke‑like brain injury dramatically cut the amount of brain damage and improved neurological scores. The protection seems to involve blocking a stress‑signalling pathway (ERK).
Kim. Su-Jeong SJ; Xiao. Jialin J; Wan. Junxiang J; Cohen. Pinchas P; Yen. Kelvin K
Humanin and related mitochondrial peptides (like MOTS‑c and SHLPs) are tiny proteins that travel in the blood and can influence how our bodies handle weight, fat, and blood sugar. Early studies show humanin may curb weight gain, reduce belly fat, and boost insulin release after meals, while MOTS‑c can strongly limit weight gain in mice fed a high‑fat diet. This review pulls together what we know so far about these peptides and how they might affect overall metabolism.
Krejcova. Gabriela G; Patocka. Jiri J; Slaninova. Jirina J
A study in rats showed that two versions of the peptide humanin can reverse memory problems caused by a drug that blocks brain chemicals important for learning. The peptides were given by injection at a specific dose and helped the animals perform better in a maze test, suggesting they might support brain function by affecting the cholinergic system.
Colón. Eugenia E; Strand. Mona-Lisa ML; Carlsson-Skwirut. Christine C; Wahlgren. Aida A; Svechn...
This rat study shows that the tiny peptide humanin is naturally made in the testis and helps Leydig cells stay alive and make more steroid hormones, especially when combined with growth factors like IGF‑I. While it hints that humanin could support testosterone production, the work is only in animals and doesn’t give dosing guidance for people.
Evangelou. Alexandra A; Zikos. Christos C; Livaniou. Evangelia E; Evangelatos. Gregory P GP
Scientists figured out a reliable way to make the 24‑amino‑acid peptide humanin in the lab using solid‑phase chemistry, even though part of its sequence is tricky to handle. This method gives a good amount of pure peptide, which is needed for any further testing or use.
Bodzioch. Marek M; Lapicka-Bodzioch. Katarzyna K; Zapala. Barbara B; Kamysz. Wojciech W; Kiec-Wilk....
Scientists discovered that the humanin peptide, known for protecting brain cells, actually comes in many slightly different forms that are made from nuclear DNA, not just mitochondria. Some of these versions are active in the body and can be turned on by things like beta‑carotene, while tiny changes in their sequence can make them work better or worse at stopping cell death.