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Humanin

HN, S14G-Humanin

A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.

Quick Stats
Studies 491
Trials 100
Formula C119H204N34O32S2
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Utility 1
pubmed Jun 21, 2002

A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.

Caricasole. Andrea A; Bruno. Valeria V; Cappuccio. Irene I; Melchiorri. Daniela D; Copani. Agata A;...

Scientists discovered a rat peptide called Rattin that is similar to the human peptide Humanin and can protect brain cells from damage caused by beta‑amyloid and excitotoxic signals. In lab tests Rattin worked as well as Humanin against amyloid toxicity and was even better at stopping damage from NMDA, a chemical that over‑activates neurons. The work is still at the cell‑culture stage and hasn’t been tested in people, so there’s no dosage or protocol to use yet.

Utility 1
pubmed Jul 22, 2020

Biochemical determinants of the IGFBP-3-hyaluronan interaction.

Dorandish. Sadaf S; Devos. Jonathan J; Clegg. Bradley B; Price. Deanna D; Muterspaugh. Robert R; Gut...

The study shows that a short piece of the protein IGFBP‑3 can stick to both hyaluronan (a sugar molecule in the body) and humanin (a tiny peptide linked to aging). This binding isn’t changed by sugar‑coating or breaking the protein’s bonds, but the way another protein, CD44, is modified with sugars affects how it competes for hyaluronan. In lung cancer cells, blocking the hyaluronan‑CD44 link reduced cell survival, hinting the IGFBP‑3 piece can influence cell growth.

pubmed Jun 27, 2023

A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.

Kose. Caner C; Korpe. Busra B; Yakut Yucel. Kadriye K; Arat. Ozgur O; Bucak. Mevlut M; Engin Ustun....

The study found that babies with late fetal growth restriction have higher levels of the peptide humanin in their umbilical cord blood, and those higher levels were linked to a greater chance of needing intensive care after birth. This doesn’t tell us how to use humanin for health or performance in adults.

pubmed Dec 13, 2024

Development of immunocompetent full thickness skin tissue constructs to model skin fibrosis for high-throughput drug screening.

Lim. Yi Wei YW; Quinn. Russell R; Bharti. Kapil K; Ferrer. Marc M; Zarkoob. Hoda H; Song. Min Jae MJ

The study describes a lab‑grown skin model that includes immune cells (macrophages) to better mimic real skin, especially for testing drugs that affect skin scarring. It doesn’t involve the peptide humanin or give any advice you can use at home.

pubmed Feb 23, 2024

The development of an<i>in vitro</i>human hair follicle organoid with a complexity similar to that<i>in vivo</i>.

Marinho. Paulo Andr&#xe9; PA; Jeong. Gyusang G; Shin. Seung Hyun SH; Kim. Su Na SN; Choi. Hyeongwon...

The study describes a new lab-grown hair follicle model that mimics real hair growth, but it doesn’t involve the peptide humanin or give any tips you can use for health, longevity, or performance. It’s mainly a technical tool for scientists studying hair loss.

pubmed Apr 10, 2023

SPEADI: Accelerated Analysis of IDP-Ion Interactions from MD-Trajectories.

de Bruyn. Emile E; Dorn. Anton Emil AE; Zimmermann. Olav O; Rossetti. Giulia G

The paper presents a new computer program that looks at how ions surround a flexible protein called humanin during simulations, but it doesn’t test humanin in people or give any health‑related advice.

pubmed Jun 28, 2024

Human iPSC-derived liver co-culture spheroids to model liver fibrosis.

Cools. Laura L; Dastjerd. Mina Kazemzadeh MK; Smout. Ayla A; Merens. Vincent V; Yang. Yuwei Y; Reyna...

This study describes a lab method to grow liver cells from stem cells in 3‑D clusters that mimic liver scarring, but it doesn’t give any advice you can use at home or any info about the peptide humanin.

pubmed Jun 1, 2022

Epigenome-wide DNA methylation in obsessive-compulsive disorder.

Schiele. Miriam A MA; Lipovsek. Jan J; Schlosser. Pascal P; Soutschek. Michael M; Schratt. Gerhard G...

Researchers found DNA methylation changes near human‑like genes (including humanin‑related genes) in people with OCD, but this doesn’t tell us how to use humanin for health.

pubmed Jul 29, 2021

Human-in-the-Loop Predictive Analytics Using Statistical Learning.

Ganesan. Anusha A; Paul. Anand A; Nagabushnam. Ganesan G; Gul. Malik Junaid Jami MJJ

The paper describes a computer‑based system that combines human input with AI to predict coma using brain‑wave data, but it does not discuss the peptide humanin or any health‑optimizing protocols for longevity, metabolism, or performance.

pubmed Nov 7, 2021

Optimized hip-knee-ankle exoskeleton assistance reduces the metabolic cost of walking with worn loads.

Bryan. Gwendolyn M GM; Franks. Patrick W PW; Song. Seungmoon S; Reyes. Ricardo R; O'Donovan. Meghan...

The study tested a hip‑knee‑ankle exoskeleton that helps people walk while carrying weight. It showed big drops (around 40‑50%) in the energy cost of walking, but the research is about the device, not the peptide humanin, so it doesn’t give any useful tips for biohackers interested in supplements or metabolic tricks.

pubmed Nov 7, 2022

Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly.

Kang. Kexin K; Shi. Qiaoni Q; Wang. Xu X; Chen. Ye-Guang YG

Scientists discovered that a protein called Dishevelled 2 can form tiny liquid droplets inside cells, which helps build a signaling complex for the Wnt pathway and breaks apart another complex that destroys beta‑catenin. This is a basic cell‑biology finding and doesn’t give any direct tips for health, longevity, or performance.

pubmed Apr 13, 2021

Towards intellectual freedom in an AI Ethics Global Community.

Ebell. Christoph C; Baeza-Yates. Ricardo R; Benjamins. Richard R; Cai. Hengjin H; Coeckelbergh. Mark...

The paper talks about problems and politics in AI ethics research, especially after recent controversies at Google. It doesn’t discuss the peptide humanin or any health‑related findings, so it isn’t useful for biohackers or anyone looking for ways to improve longevity, metabolism, or performance.

pubmed Aug 23, 2020

Decoding the rosetta stone of mitonuclear communication.

English. Justin J; Son. Jyung Mean JM; Cardamone. Maria Dafne MD; Lee. Changhan C; Perissi. Valentin...

This paper reviews how mitochondria talk to the cell nucleus to keep cells healthy, but it doesn’t give any specific tips or experiments you can try.

pubmed Oct 4, 2022

Relative assessment of cloth mask protection against ballistic droplets: A frugal approach.

M&#xe1;rquez-Alvarez. Victor V; Amig&#xf3;-Vega. Joaqu&#xed;n J; Rivera. Aramis A; Batista-Leyva. Al...

This paper tested homemade cloth masks using a cheap stain method and found they stop most fast‑moving droplets that could carry COVID‑19. Masks work better at protecting people around you than protecting yourself, and a simple physics model can explain how they block droplets. The study doesn’t involve the peptide humanin, so it isn’t directly useful for biohackers interested in that molecule.

pubmed Oct 5, 2021

Bayesian supervised machine learning classification of neural networks with pathological perturbations.

Levi. Riccardo R; Valderhaug. Vibeke Devold VD; Castelbuono. Salvatore S; Sandvig. Axel A; Sandvig....

The paper describes a machine‑learning method for sorting lab‑grown brain cell networks into healthy or diseased groups based on their electrical activity. It doesn’t involve the peptide humanin or suggest any health‑related protocol, so it offers no practical guidance for biohackers or longevity enthusiasts.

pubmed Feb 22, 2022

Human<i>in vivo</i>liver and tumor bioimpedance measured with biopsy needle.

Halonen. Sanna S; Ovissi. Ali A; Boyd. Sonja S; Kari. Juho J; Kronstr&#xf6;m. Kai K; Kosunen. Juhani...

Researchers tested a new biopsy needle that can measure the electrical resistance (bioimpedance) of liver and tumor tissue during a liver biopsy. They found that liver and tumor tissue show different resistance at certain low and high frequencies, but the measurements varied a lot between patients and overlapped, so the method isn’t yet reliable for everyday use.

pubmed Jun 24, 2013

Humanin: a novel functional molecule for the green synthesis of graphene.

Gurunathan. Sangiliyandi S; Han. JaeWoong J; Kim. Jin Hoi JH

Scientists found that the tiny protein humanin can act like a safe chemical to turn graphene oxide into graphene, which could be useful for making medical devices, but this study doesn’t tell you anything about taking humanin for health or performance.

pubmed 2015

A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics.

Santulli. Gaetano G

The paper talks about tiny RNA molecules that control genes and how some RNAs thought to be non‑coding actually hide tiny proteins called micropeptides. It describes how many miRNAs exist, their gene‑target interactions, and new tools to find hidden micropeptides, but it doesn’t discuss humanin or give any direct health tips.