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HN, S14G-Humanin
A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.
Rossini. Lara L; Hashimoto. Yuichi Y; Suzuki. Hiroaki H; Kurita. Megumi M; Gianfriddo. Marco M; Scal...
Scientists discovered a protein called VSTM2L that sticks to the anti‑aging peptide Humanin and blocks its brain‑protective actions. This natural blocker is found in the blood and brain, meaning it could reduce the benefits of taking Humanin as a supplement.
Wang. Tao T; Huang. Ya Y; Zhang. Mingyang M; Wang. Long L; Wang. Yaoqi Y; Zhang. Lu L; Dong. Wenwen...
In a mouse study, a modified form of the peptide humanin (called HNG) given shortly after a brain bleed helped reduce swelling, shrink the damaged area, and improve movement and behavior. The benefit seems to come from turning on a cell‑survival pathway (PI3K‑Akt) and blocking a protein (GSK‑3β) that leads to cell death. The effect disappeared when a drug that blocks this pathway was used, confirming the mechanism.
Maftei. Madalina M; Tian. Xiaodan X; Manea. Marilena M; Exner. Thomas E TE; Schwanzar. Daniel D; von...
Scientists mapped how the tiny 24‑amino‑acid peptide humanin sticks to the Alzheimer‑related beta‑amyloid protein, pinpointing the exact parts of each that lock together and measuring a moderate binding strength (about 610 nM). This helps explain why humanin can protect brain cells in lab tests, but it’s still early‑stage research, not a ready‑to‑use supplement guide.
Hashimoto. Y Y; Nawa. M M; Kurita. M M; Tokizawa. M M; Iwamatsu. A A; Matsuoka. M M
Scientists found a skin‑derived protein called CLSP that can protect brain cells from death linked to Alzheimer’s disease, working through the same receptor as the peptide Humanin but far more powerfully. It’s naturally present in the blood and can reach the brain’s fluid in mice, hinting it might be a natural brain‑protective factor.
Zhu. Wa-Wa WW; Wang. Shu-Rong SR; Liu. Zhi-Hua ZH; Cao. Yong-Jun YJ; Wang. Fen F; Wang. Jing J; Liu....
A modified form of the naturally occurring peptide humanin (called HNG) was shown in mouse immune cells to cut down the amount of bad cholesterol that gets taken up and to boost the removal of cholesterol, which together prevented the cells from turning into the fatty “foam cells” that start plaque in arteries. This was all done in a dish, not in people.
Jia. Y Y; Lue. Y-H YH; Swerdloff. R R; Lee. K-W KW; Cobb. L J LJ; Cohen. P P; Wang. C C
In rats, giving the peptide humanin directly into the testicles helped protect sperm‑producing cells from dying when the animals were hormonally stressed. The peptide lowered a death‑promoting protein called BAX in the mitochondria and shifted cell‑signaling pathways toward survival. However, the study used invasive injections in animals, so it doesn’t give a ready‑to‑use human protocol.
Park. Tae-Yoon TY; Kim. Seung-Hyung SH; Shin. Yoon-Chul YC; Lee. Nae-Hyun NH; Lee. Rae-Kyung Christi...
Scientists created a modified version of the peptide humanin that can cross the brain’s protective barrier and stop cell‑death signals, showing it protects brain cells and improves memory in mouse models of Alzheimer’s and stroke, performing as well as the drug Aricept. However, this work is still in animals, so it isn’t ready for personal use yet.
Nikolakopoulos. Panagiotis P; Tzimagiorgis. Georgios G; Goulis. Dimitrios G DG; Chatzopoulou. Fani F...
The study found that pregnant women with pre‑eclampsia have higher levels of the tiny protein humanin in their blood compared to healthy pregnant women, hinting that humanin might help protect against the oxidative stress and blood‑vessel problems seen in this condition.
Zacharias. David G DG; Kim. Sung Gyun SG; Massat. Alfonso Eirin AE; Bachar. Adi R AR; Oh. Yun K YK;...
The research shows that the naturally occurring peptide humanin is found at higher levels in unstable carotid artery plaques of patients who have had symptoms like strokes, and it appears in many cell types linked to inflammation and cell death. This suggests humanin might be part of the body’s response to plaque damage, but the study does not test taking the peptide as a treatment.
Zhao. Hui H; Sonada. Soushi S; Yoshikawa. Akihiro A; Ohinata. Kousaku K; Yoshikawa. Masaaki M
The study shows that the peptide humanin, which naturally occurs in the body, can reduce anxiety-like behavior in mice when directly injected into the brain, acting through a specific receptor (FPR2) and downstream pathways involving prostaglandin, adenosine, and GABA systems.
Lee. Changhan C; Yen. Kelvin K; Cohen. Pinchas P
Humanin is a tiny protein that comes from mitochondria and appears to protect cells from stress and disease. Researchers think it could be part of a larger group of mitochondrial peptides that send signals back to the cell, influencing health and aging. While the idea is exciting, the paper mainly discusses the concept and potential, without giving concrete dosing or treatment guidelines.
Arakawa. T T; Hirano. A A; Shiraki. K K; Niikura. T T; Kita. Y Y
Humanin is a tiny protein that can protect brain cells from damage caused by amyloid‑beta and other stresses. Scientists have found several proteins that humanin can stick to, but they still don’t know exactly how the binding works. This paper looks at how humanin’s shape changes in different liquids and tries to link those shapes to its protective effects.
Hashimoto. Yuichi Y; Takeshita. Yuji Y; Naito. Mikihiko M; Uchino. Hiroyuki H; Matsuoka. Masaaki M
Humanin, a tiny protein fragment, can turn on a cell‑survival pathway that raises levels of a protein called Apollon/Bruce, which helps protect brain cells from dying in an Alzheimer’s‑related model. This shows another way Humanin might support brain health, but the study is still at the cell‑culture stage and doesn’t give dosing or real‑world usage tips.
Wang. T T; Zhang. L L; Zhang. M M; Bao. H H; Liu. W W; Wang. Y Y; Wang. L L; Dai. D D; Chang. P P; D...
A mouse study found that a modified humanin peptide (HNG) given directly into the brain or shortly after injury can shrink damage and improve movement and memory after a traumatic brain injury, likely by blocking cell‑death processes.
Chen. Jing J; Sun. Miao M; Zhang. Xia X; Miao. Zhigang Z; Chua. Balvin H L BH; Hamdy. Ronald C RC; Z...
A special version of the humanin peptide (called HNG) helped brain cells that make myelin (the protective coating on nerves) grow back after a stroke-like injury in baby rats. Giving the peptide right before the injury cut the damage size, and giving it a day later didn’t shrink the damage but did improve movement, reduce brain shrinkage, and boost repair of nerve fibers after two weeks.
Mottaghi-Dastjerdi. Negar N; Soltany-Rezaee-Rad. Mohammad M; Sepehrizadeh. Zargham Z; Roshandel. Gho...
The study found that the small peptide humanin is produced at much higher levels in stomach cancer cells and may help those cells resist chemotherapy, suggesting that blocking humanin could improve cancer treatment. For biohackers, this means that taking humanin supplements might carry a risk of supporting cancer cell survival, so caution is advised, especially for anyone with cancer risk or existing disease.
Zhang. Wei W; Du. Ying Y; Bai. Miao M; Xi. Ye Y; Li. Zhuyi Z; Miao. Jianting J
A lab study found that a synthetic version of the peptide humanin, called S14G‑humanin (HNG), can stop the sticky amyloid‑beta proteins that cause Alzheimer’s from clumping together and can even break apart clumps that have already formed, protecting nerve‑like cells from damage in a dish.
Lee. Changhan C; Zeng. Jennifer J; Drew. Brian G BG; Sallam. Tamer T; Martin-Montalvo. Alejandro A;...
MOTS‑c is a tiny protein made by mitochondria that, in mouse studies, helped keep blood sugar stable, boosted muscle insulin sensitivity, and stopped weight gain from high‑fat diets by turning on the energy‑sensing AMPK pathway.
Cobb. Laura J LJ; Lee. Changhan C; Xiao. Jialin J; Yen. Kelvin K; Wong. Richard G RG; Nakamura. Hiro...
The study shows that humanin and two related tiny proteins (SHLP2 and SHLP3) made by mitochondria can protect cells from death, lower harmful oxidative stress, boost mitochondrial function, and improve how the body handles glucose, at least in lab dishes and mouse experiments. Their levels naturally drop as we get older, hinting they might be part of why metabolism worsens with age.
Yuan. Li L; Liu. Xiao-Jie XJ; Han. Wei-Na WN; Li. Qing-Shan QS; Wang. Zhao-Jun ZJ; Wu. Mei-Na MN; Ya...
A study in rats showed that a modified version of the peptide humanin, called HNG, can protect brain cells from the memory‑damaging effects of a small piece of the Alzheimer‑related amyloid‑beta protein. The protection seems to involve keeping certain cell‑survival signals (STAT3) active and preventing cell‑death signals (caspase‑3). However, the experiments used direct brain injections, not oral or injectable doses that people could realistically use.