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HN, S14G-Humanin
A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.
Hashimoto. Yuichi Y; Terashita. Kenzo K; Niikura. Takako T; Yamagishi. Yohichi Y; Ishizaka. Miho M;...
Humanin protects brain cells by pairing up with another copy of itself. Certain tiny changes (mutations) in the peptide stop it from pairing, which blocks its protective effect. This shows the importance of the pairing for its function, but doesn’t give any dosing or usage tips.
Zapała. Barbara B; Kaczyński. Łukasz Ł; Kieć-Wilk. Beata B; Staszel. T...
Humanin is a tiny protein that helps protect brain cells and other cells from dying, mainly by blocking stress pathways and inflammation. It’s been shown in lab and animal studies to guard against things like Alzheimer’s‑type damage, mitochondrial disorders, and even damage to insulin‑producing cells, but there’s no clear human dosing or proven benefit yet.
Xu. Xingshun X; Chua. Chu Chang CC; Gao. Jinping J; Chua. Kao-Wei KW; Wang. Hong H; Hamdy. Ronald C...
Humanin’s modified form (HNG) helps brain cells survive low‑oxygen stress in mouse experiments, and it does this by turning on the PI3K/Akt survival pathway. When the pathway is blocked, the protection disappears, and giving HNG to mice before a stroke‑like event shrinks brain damage.
Ikonen. Maaria M; Liu. Bingrong B; Hashimoto. Yuichi Y; Ma. Liqun L; Lee. Kuk-Wha KW; Niikura. Takak...
Humanin is a tiny protein that can stick to another protein called IGFBP‑3, and this partnership can change how cells survive or die. In some lab tests, humanin helped protect brain cells from Alzheimer‑related damage, especially when IGFBP‑3 was around, but it didn’t work the same way in all cell types. The study shows the interaction is real but still early‑stage, with no clear dosing or human data yet.
Hoang. Phuong T PT; Park. Patricia P; Cobb. Laura J LJ; Paharkova-Vatchkova. Valdislava V; Hakimi. M...
Humanin, a small protein that helps brain cells survive, also protects insulin‑producing pancreatic cells from dying and improves blood sugar control in a mouse model of type‑1 diabetes, but the work is still early and only in animals.
Xu. Xingshun X; Chua. Kao-Wei KW; Chua. Chu C CC; Liu. Chun-Feng CF; Hamdy. Ronald C RC; Chua. Balvi...
A study in mice found that a humanin variant (HNG) and a drug called necrostatin‑1 each protect brain cells from oxygen loss, and together they work even better, cutting brain damage after a stroke‑like event. However, the experiments used direct brain injections and a drug not widely available, so it’s not yet a practical home protocol.
Hashimoto. Yuichi Y; Kurita. Megumi M; Matsuoka. Masaaki M
Scientists found that a shorter version of a protein called WSX-1, which floats outside cells, can join with other proteins to form a receptor that lets the peptide Humanin protect brain cells from Alzheimer‑related damage. This shows Humanin can work through more than one receptor setup.
Tajima. Hirohisa H; Kawasumi. Masaoki M; Chiba. Tomohiro T; Yamada. Marina M; Yamashita. Kaoru K; Na...
A specially tweaked version of the humanin peptide (S14G‑HN) stopped memory loss caused by amyloid‑beta in mice, but it had to be injected straight into the brain, so it isn’t something you can take as a supplement today.
Jin. Hui H; Liu. Tao T; Wang. Wei-Xi WX; Xu. Jie-Hua JH; Yang. Peng-Bo PB; Lu. Hai-Xia HX; Sun. Qin-...
A lab study showed that a modified version of the peptide humanin (called HNG) can protect nerve-like cells from damage caused by a piece of the Alzheimer's protein beta‑amyloid, mainly by keeping the cells' mitochondria healthy. However, this was done in a petri dish, not in people, so it’s not yet a ready‑to‑use protocol for health‑optimizers.
Kunesová. Gabriela G; Hlavácek. Jan J; Patocka. Jirí J; Evangelou. Alexandra A; Zikos...
Scientists tested several versions of the peptide humanin in rats and found that only certain full‑length forms, especially the hybrid peptide colivelin, could reverse drug‑induced memory problems. Shortened or modified versions didn’t work. This suggests that specific humanin analogues might help protect brain function, but the work is still early and done in animals.
Arakawa. Tsutomu T; Niikura. Takako T; Tajima. Hirohisa H; Kita. Yoshiko Y
The study shows that the humanin peptide (especially a Ser14Gly version) is mostly floppy in plain water but folds a bit when placed in a salty buffer like PBS, especially at higher amounts and warmer temperatures. This folding is due to the peptide sticking to itself through water‑shunning (hydrophobic) forces. The normal humanin behaves the same way, but the concentrations needed to see these effects are much higher than what you'd find in the body.
Kigawa. Akihiro A; Wakui. Hideki H; Maki. Nobuki N; Okuyama. Shin S; Masai. Rie R; Ohtani. Hiroshi H...
Scientists discovered that the anti‑aging peptide humanin directly binds to a specific region of the kidney protein actinin‑4, showing a new molecular partnership in podocyte cells, but this finding doesn’t translate into any immediate supplement or treatment advice.
Miao. Jianting J; Zhang. Wei W; Yin. Rong R; Liu. Rui R; Su. Changjun C; Lei. Gesheng G; Li. Zhuyi Z
In a mouse study, a modified version of the natural peptide humanin (called S14G‑humanin or HNG) was given by injection and was found to improve memory problems caused by an Alzheimer‑related protein, while also lowering brain inflammation and cell death markers.
Arisaka. Fumio F; Arakawa. Tsutomu T; Niikura. Takako T; Kita. Yoshiko Y
The study found that the active humanin peptide and an inactive version look the same in a simple phosphate solution – they’re both floppy, single‑chain molecules and don’t form a specific shape, and this doesn’t explain why one works and the other doesn’t. They also showed that the peptides tend to clump together unless the phosphate level is kept low.
Lue. YanHe Y; Swerdloff. Ronald R; Liu. QingHai Q; Mehta. Hemal H; Hikim. Amiya Sinha AS; Lee. Kuk-W...
The study shows that a protein called IGFBP3 makes testicular cells die, while another protein, humanin, can protect some of those cells from dying. In mice lacking IGFBP3, fewer cells died, and giving humanin directly into the testis reduced death caused by a hormone blocker. These effects were seen only in specific stages of sperm development and were observed in animal experiments, not humans.
Kita. Yoshiko Y; Niikura. Takako T; Arisaka. Fumio F; Arakawa. Tsutomu T
The study shows that two Humanin‑like peptides change shape in complex ways when mixed with the detergent SDS or the solvent TFE, becoming more uniform at higher concentrations and less clumped together. This behavior happens even below the level where SDS forms micelles, meaning the peptide interacts directly with individual detergent molecules.
Choi. Jungyuen J; Zhai. Dayong D; Zhou. Xin X; Satterthwait. Arnold A; Reed. John C JC; Marassi. Fra...
Humanin, a tiny naturally occurring peptide, sticks to a specific part of the cell‑death protein Bid, stopping Bid from teaming up with other proteins that trigger apoptosis. This binding could help protect cells from damage, hinting at a way to boost cell survival.
Hashimoto. Yuichi Y; Suzuki. Hiroaki H; Aiso. Sadakazu S; Niikura. Takako T; Nishimoto. Ikuo I; Mats...
Humanin can protect brain cells from Alzheimer‑related damage, but it doesn’t work through the previously thought FPR2 receptor. Instead, it activates the STAT3 protein and some tyrosine‑kinase enzymes, meaning another yet‑unknown receptor is likely involved.
Armas. Ambar A; Sonois. Vanessa V; Mothes. Emmanuelle E; Mazarguil. Honoré H; Faller. Peter P
Humanin is a tiny protein that can protect brain cells from the damage caused by amyloid‑beta, a key player in Alzheimer’s. This study shows that zinc ions can attach directly to humanin at a specific cysteine spot, with a binding strength in the low‑micromolar range—about the same as zinc’s interaction with amyloid‑beta itself. While this hints that zinc levels might influence humanin’s protective effects, the work is purely lab‑based and doesn’t give direct dosing advice.
Muzumdar. Radhika H RH; Huffman. Derek M DM; Calvert. John W JW; Jha. Saurabh S; Weinberg. Yoni Y; C...
In mouse experiments, giving a stronger version of the natural peptide humanin (called HNG) before or right after a simulated heart attack cut the amount of heart tissue that died and helped the heart pump better afterward. The protection seems to come from turning on energy‑regulating pathways (AMPK and eNOS) and lowering cell‑death signals.