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HN, S14G-Humanin
A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.
Zhang. Zhenkun Z; Sheng. Meijun M; Bao. Yiyao Y; Tang. Chao C
The paper reviews how sepsis can damage kidneys in seriously ill kids and talks about many biological pathways and new biomarkers that could help detect and treat this problem. It mentions Humanin as a possible drug that might calm the immune response, but this is still experimental and not tested in humans for this use.
Demirkiran. Cahit C; Mete. Alper A; Demiryürek. Abdullah Tuncay AT; Saracaloglu. Ahmet A; Demir...
The study found that in people with the eye condition keratoconus, a mitochondrial peptide called humanin was higher in more severe cases, while another mitochondrial peptide was lower, and signs of nitrosative stress and a type of cell death called ferroptosis were increased. This suggests these peptides and stress pathways might play a role in the disease, but the research does not test any treatments or give dosing advice.
Kütük. Duygu D; Öner. Çağrı Ç; Başar. Murat M; Akcay. Ber...
This study looked at how the natural peptide humanin is expressed in the fluid surrounding embryos from different types of infertile women. It found that humanin levels change depending on the infertility condition, suggesting the fluid could hint at mitochondrial health, but it doesn’t tell you how to use humanin as a supplement or treatment.
Daly. Grant T GT; Hartsell. Emily M EM; Pastukh. Viktor M VM; Roberts. Justin T JT; Haastrup. Adeyey...
Researchers looked at tiny pieces of mitochondrial DNA in the blood of people with severe lung problems. They found that very short DNA fragments are linked to higher death rates, and a specific genetic change in a humanin‑like gene (MT‑SHLP3) was tied to better survival. Other DNA changes were linked to worse outcomes, but the study doesn’t tell us how to use humanin as a supplement or therapy.
Assis-Mendonça. Guilherme Rossi GR; Athié. Maria Carolina Pedro MCP; Tamanini. João V...
The study looked at brain tissue from people with a type of epilepsy and found that a gene related to the humanin peptide (MTRNR2L12) was higher in some lesions, while cholesterol‑making enzymes were also increased, possibly as a protective response. However, it doesn’t test humanin as a treatment or give any dosing advice.
Ruiz. David D; Santibañez. Miguel M; Lavín. Bernardo Alio BA; Berja. Ana A; Montalban. Cor...
The study measured two tiny proteins made by mitochondria, humanin and MOTSc, in pregnant women and found both drop as pregnancy progresses. Lower MOTSc levels in the second trimester were linked to higher insulin resistance, while humanin didn’t show a clear connection. No experiments tested taking these peptides, so the findings are mostly observational.
Sims. Natalie A NA
This paper is a broad review of the IL‑6 family of signaling proteins, which includes humanin, and how they affect bone cells and overall bone health. It mainly describes the roles of these proteins in bone formation, resorption, and disease, but doesn’t give specific experiments or dosing advice for humanin. For DIY health enthusiasts, the information is mostly background and not directly usable for a protocol.
Amici. David R DR; Pinal-Fernandez. Iago I; Christopher-Stine. Lisa L; Mammen. Andrew L AL; Mendillo...
Researchers mapped gene activity in muscle biopsies from people with different types of myositis and found many patterns, including that a version of the anti‑death peptide humanin is lower in these patients. While the study points to many possible drug targets, it doesn’t give direct advice on using humanin or other interventions for health optimization.
Féménia. M M; Charles. M M; Boulling. A A; Rocha. D D
Scientists mapped pieces of mitochondrial DNA that have moved into the sheep’s nuclear DNA, finding about 390 such regions. Most of these are in non‑coding parts of the genome and aren’t active, but a few might code for new versions of the peptide humanin. They also showed that these nuclear copies can mess up DNA tests if you’re not careful with primer design.
Amado. Carlos A CA; Martín-Audera. Paula P; Agüero. Juan J; Lavín. Bernardo A BA; Gue...
The study found that people with COPD have higher blood levels of the mitochondrial peptide humanin, and those with the highest levels tend to have more flare‑ups, poorer nutrition and lower exercise capacity. In short, higher humanin was linked to worse disease outcomes, not a benefit.
Eltermaa. Mall M; Jakobson. Maili M; Utt. Meeme M; Kõks. Sulev S; Mägi. Reedik R; Starkopf...
The study checked whether common genetic differences in humanin‑related genes affect heart disease risk and found no solid link after proper statistical correction.
Logan. Ian S IS
The study found that the tiny gene that makes the peptide Humanin is still working in almost all humans, but in many other animals the gene has become broken, which could mess up how useful those animals are for testing Humanin‑related treatments.
Gottardo. María Florencia MF; Pidre. Matías L ML; Zuccato. Camila C; Asad. Antonela S AS;...
Scientists used a virus to turn off the humanin gene in pituitary tumor cells and in mice, which made the cancer cells die more and slowed tumor growth, showing that natural humanin helps protect these tumor cells.
Kusakari. Shinya S; Nawa. Mikiro M; Sudo. Katsuko K; Matsuoka. Masaaki M
In mice engineered to have more of a protein called CLSP, memory problems and loss of brain connections caused by an Alzheimer’s model were reduced, even though the usual Alzheimer’s markers like amyloid‑beta didn't change.
Kim. Su-Jeong SJ; Xiao. Jialin J; Cohen. Pinchas P; Yen. Kelvin K
The paper describes a simple lab technique to measure how the mitochondrial peptide humanin activates the ERK signaling pathway inside cells, using cell fractionation and western blotting. It doesn’t give dosing advice or direct health benefits for humans, but offers a tool for researchers to study humanin’s mechanisms.
Wang. Sheng-Fan SF; Chen. Shiuan S; Tseng. Ling-Ming LM; Lee. Hsin-Chen HC
The paper reviews how messed‑up mitochondria can help cancers grow and lists several mitochondrial signals—including the peptide humanin—that might drive this process. It suggests that blocking these signals could be a way to treat cancer, but it doesn’t give any concrete humanin dosing or lifestyle tips.
Baldauf. Claire C; Sondhi. Monica M; Shin. Bo-Chul BC; Ko. Young Eun YE; Ye. Xin X; Lee. Kuk-Wha KW;...
A study in mice showed that cutting the mother’s food in half during pregnancy makes baby brains smaller and reduces many brain cell types. The protective peptide called Humanin is naturally highest right before birth and drops after, with female stressed babies showing a bigger increase in Humanin than males. This suggests Humanin may help protect the brain during early nutrient shortage, but the work is purely animal‑based and doesn’t give any clear steps you can take.
Ahn. Chang Ho CH; Choi. Eun Hye EH; Kong. Byung Soo BS; Cho. Young Min YM
The study tested a mitochondrial peptide called MOTS‑c on cells with a common mitochondrial DNA mutation that causes poor energy production. Adding MOTS‑c from outside or making the cells produce it themselves didn’t boost the cells’ ATP levels, respiratory function, or the proteins that run the energy factories. In short, MOTS‑c didn’t fix the mitochondrial problem in this model.
Dubin. Arseny A; Jørgensen. Tor Erik TE; Jakt. Lars Martin LM; Johansen. Steinar Daae SD
Scientists mapped the full mitochondrial DNA and RNA of the anglerfish and found lots of ribosomal RNA, unusually high levels of certain protein‑coding RNAs, and some new long non‑coding RNAs. They also spotted a tiny peptide that looks like the human longevity peptide humanin, but it’s in fish mitochondria and its function isn’t known for humans.
Blasiak. Janusz J
The paper talks about how aging cells that stop dividing (senescent cells) may cause damage in the eye leading to age‑related macular degeneration (AMD). It mentions that a tiny protein called humanin, which comes from mitochondria, could be part of this process, but it doesn’t give any direct ways to use humanin for prevention or treatment. The authors suggest that drugs that clear senescent cells (senolytics) or block their harmful signals (senostatics) might help in the future, but no specific protocols are provided.