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HN, S14G-Humanin
A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.
Merdzo. Ivan I; Rutkai. Ibolya I; Sure. Venkata N L R VNLR; Katakam. Prasad V G PVG; Busija. David W...
In rats with long‑term type 2 diabetes, the brain’s blood vessels show lower mitochondrial breathing activity, a slight (non‑significant) drop in the humanin‑like peptide rattin, and higher harmful superoxide levels, but overall the mitochondrial system seems to hold steady rather than get worse.
Oh. Yun K YK; Bachar. Adi R AR; Zacharias. David G DG; Kim. Sung Gyun SG; Wan. Junxiang J; Cobb. Lau...
In mice that are prone to develop artery plaque, a synthetic version of the mitochondrial peptide humanin (called HNGF6A) given daily for 4 months helped keep blood vessels working properly and made the plaques smaller, even though it didn’t lower cholesterol or change overall inflammation levels.
Gong. Zhenwei Z; Tas. Emir E; Muzumdar. Radhika R
Humanin is a tiny protein made in mitochondria that seems to help cells survive stress, control metabolism, and reduce inflammation. Studies in cells and animals suggest it could protect against diseases linked to aging like Alzheimer’s, stroke, diabetes, heart damage, and some cancers, and it may be tied to the growth hormone/IGF system that influences lifespan. However, the paper is a review and doesn’t give specific dosing or protocols for humans.
Zhang. Xin X; Urbieta-Caceres. Victor H VH; Eirin. Alfonso A; Bell. Caitlin C CC; Crane. John A JA;...
In a mouse study, the naturally occurring peptide humanin helped protect kidneys from damage caused by high cholesterol, reducing tiny blood‑vessel changes, inflammation and cell death. The work was done in genetically modified mice and used daily injections, so it’s not yet a ready‑to‑use treatment for people.
Mortz. Mathieu M; Dégletagne. Cyril C; Romestaing. Caroline C; Duchamp. Claude C
Scientists compared bird mitochondrial DNA and found that birds have tiny genes that can make peptides similar to the human peptide Humanin. These tiny genes are almost identical across many bird species, which suggests they’re important and have been kept unchanged through evolution.
Voigt. Annet A; Jelinek. Herbert F HF
The study found that people with slightly high fasting blood sugar (impaired fasting glucose) have lower levels of a tiny protein called humanin in their blood, which may signal early oxidative stress linked to diabetes. Humanin is known to help protect cells from damage and improve insulin sensitivity in animal tests, but this is the first human data showing its levels drop when blood sugar starts to rise.
Yang. Yingxi Y; Gao. Huijuan H; Zhou. Huan H; Liu. Qi Q; Qi. Zhongwen Z; Zhang. Ying Y; Zhang. Junpi...
This review says tiny proteins made by mitochondria, like Humanin, help protect heart cells and may lower heart disease risk, but the science is still early and no clear dosing advice exists.
Matsunaga. Douglas D; Sreekumar. Parameswaran G PG; Ishikawa. Keijiro K; Terasaki. Hiroto H; Barron....
The study shows that the tiny protein humanin can shield eye‑cell and brain‑cell models from death caused by stress in the cell’s protein‑making factory, mainly by boosting a key antioxidant inside mitochondria. It works better at higher doses in the lab, but the work is still only in petri dishes, not people.
Murakami. Minetaka M; Nagahama. Masatoshi M; Maruyama. Takuma T; Niikura. Takako T
A special form of the naturally occurring peptide humanin (called S14G‑humanin) helped mice recover memory that was blocked by the sedative drug diazepam, without changing their anxiety levels or movement. This shows the peptide can boost brain function in a specific drug‑induced situation, but the work is still only in animals.
Negintaji. Kourosh K; Zarifkar. Asadollah A; Ghasemi. Rasoul R; Moosavi. Maryam M
In a rat study where a drug that messes up brain insulin signaling caused memory problems, giving the peptide humanin (in several doses) did not improve the rats' memory or fix the related brain signaling changes.
Njomen. Evert E; Evans. Hedeel G HG; Gedara. Samanthi H SH; Heyl. Deborah L DL
The study shows that the naturally‑declining peptide humanin can stick to a protein called IGFBP3 and stop it from entering the cell nucleus, which normally leads to cell death. A short version of humanin does the same thing and even lowered death rates in a lab‑grown lung cancer cell line, suggesting a possible way it protects brain cells as we age.
Matsuoka. Masaaki M
Humanin is a tiny protein that may protect brain cells from the damage that leads to Alzheimer’s disease. The study says that people with Alzheimer’s have lower levels of this protective signal, and boosting it could potentially slow or prevent the disease, but it doesn’t give a clear way to do that yet.
Cui. Ai-Ling AL; Li. Jian-Zhong JZ; Feng. Zhi-Bo ZB; Ma. Guo-Lin GL; Gong. Liang L; Li. Chun-Ling CL...
Humanin, a tiny protein originally found in Alzheimer’s patients, can protect rat brain cells in a dish from damage caused by an excitatory chemical called NMDA, but it does this without blocking the NMDA receptor itself. The protection works at very low (nanomolar) doses, though the exact way it helps isn’t clear yet.
Kumfu. Sirinart S; Charununtakorn. Savitree T ST; Jaiwongkam. Thidarat T; Chattipakorn. Nipon N; Cha...
In rats, a heart attack that’s followed by blood flow returning (ischemia‑reperfusion) damages the brain’s mitochondria, breaks down the blood‑brain barrier, and raises oxidative stress. Giving the peptide humanin right before the heart attack helped keep the brain’s mitochondria working better, but it didn’t stop the barrier leak or the oxidative damage, and giving it later had no benefit.
Cohen. Aviv A; Lerner-Yardeni. Jenny J; Meridor. David D; Kasher. Roni R; Nathan. Ilana I; Parola. A...
A special version of the humanin peptide, called AGA(C8R)-HNG17, was shown in lab cells and mouse brain‑injury tests to keep nerve cells alive by stopping a type of cell death called necrosis. It does this by helping mitochondria make more energy (ATP). While the results are promising for conditions like traumatic brain injury, stroke, or heart attacks, the work is still early‑stage and not ready for personal use or dosing guidelines.
Charununtakorn. Savitree T ST; Shinlapawittayatorn. Krekwit K; Chattipakorn. Siriporn C SC; Chattipa...
Humanin is a small protein that appears to help protect heart cells from the kind of programmed death that contributes to heart disease. The review talks about how it works both outside and inside cells and suggests it could become a new drug to reduce heart damage, but it doesn’t give specific dosing or how to use it now.
Kuliawat. Regina R; Klein. Laura L; Gong. Zhenwei Z; Nicoletta-Gentile. Marianna M; Nemkal. Anjana A...
A stronger version of the tiny protein humanin (called HNGF6A) was shown to make the pancreas release more insulin when blood sugar is high, both in live rats and in isolated mouse cells. The effect grew with higher doses, didn’t rely on the usual K‑ATP channel route, and seemed tied to better glucose processing inside the cells. While promising for diabetes, the work is still early‑stage animal research, not a ready‑to‑use protocol for people.
Mahboobi. Hamidreza H; Golmirzaei. Javad J; Gan. Siew H SH; Jalalian. Mehrdad M; Kamal. Mohammad A M...
The article explains that people with type 2 diabetes are more likely to develop Alzheimer’s disease and that it progresses faster. It highlights a tiny mitochondrial peptide called humanin that can protect brain cells and may influence the same harmful processes seen in both conditions, such as insulin resistance, oxidative stress, advanced glycation end‑products, and low‑grade inflammation. Humanin itself isn’t a marketed supplement yet, but the findings suggest that targeting these shared pathways could be beneficial.
Chin. Yung-Ping YP; Keni. Jyotsna J; Wan. Junxiang J; Mehta. Hemal H; Anene. Francine F; Jia. Yue Y;...
This study looked at how long humanin and its tweaked versions stay in the blood of mice and rats after an injection. The modified versions (HNG and HNGF6A) lasted longer than the natural peptide, and giving HNG lowered some growth‑factor proteins (IGF‑1 and IGFBP‑3). In rats, humanin was mostly found in the blood and liver, not in the brain or heart. The work hints that these engineered peptides could be more useful as drugs, especially for diabetes, but it doesn’t give clear dosing advice for people.
Xie. Ying Y; Liu. Zhi-Hua ZH; Li. Xiao-Yun XY; Zhou. Yan-de YD; Xu. Xingshun X; Hu. Li-Fang LF; Zhan...
The study shows that a modified form of the peptide humanin (called HNG) can protect blood‑vessel cells in a dish from dying when exposed to high sugar levels, mainly by lowering stress signals and shifting the balance toward cell‑survival proteins.