Bailey. Victoria N VN; Sones. Jennifer L JL; Camp. Caroline M CM; Gomes. Viviane C L VCL; Oberhaus....
In a small study with 18 out‑of‑season mares, adding the peptide kisspeptin‑10 to a hormone regimen (estradiol benzoate plus sulpiride) made more horses show early ovarian activity and did it faster. The treated horses also had higher spikes in LH and prolactin hormones compared to controls.
In rats, a drug that blocks kisspeptin (called p234) lowered brain wave activity and reduced seizure-like spikes when it was given before a seizure trigger, but the natural kisspeptin peptide itself had no effect. This was a lab study on brain activity, not a human trial.
Shah. Hetvi H; Mohan. Adikrishna Murali AM; Buch. Lipi L; Ramachandran. A V AV; Pandya. Parth P
Scientists gave a small protein called kisspeptin‑10 to aggressive breast‑cancer cells in a dish. The cells grew less, moved less, and showed signs of dying, while the cells also turned on genes that usually suppress tumors. These effects were seen only in lab experiments, not in people.
Heeralall. C C; Ibrahim. U H UH; Jenneker. M M; Singh. S S; Matjila. M M; Lazarus. L L; Mackraj. I I
A study in South Africa found that pregnant women who had COVID‑19 showed higher levels of the hormone kisspeptin in their placentas, along with more inflammation and blood‑vessel damage, suggesting the virus may hurt placental health.
Carbonari. Alice A; Martino. Nicola Antonio NA; Burgio. Matteo M; Cicirelli. Vincenzo V; Frattina. L...
The study looked at dairy cows with ovarian cysts and found that these cows had higher blood levels of kisspeptin-10 and other hormones, while the receptors for kisspeptin in the cysts were reduced. This suggests a feedback loop where too much kisspeptin may lower its own receptor in the ovary.
Rizzo. Annalisa A; Maresca. Laura L; Ceci. Edmondo E; Guaricci. Antonio A; Sciorsci. Raffaele Luigi...
In pregnant dairy cows, the hormone kisspeptin‑10 (Kp‑10) first stays steady, rises around day 90‑120, drops again, and then rises one more time near the end of pregnancy. The opposite hormone, GnIH, falls early, climbs later, and both hormones go up together in the final weeks. Other hormones like cortisol stay mostly the same, while estradiol spikes twice.
Researchers examined 90 kids with unusually early puberty and found that about 12% had genetic or epigenetic reasons, mainly a disorder called TS14 or defects in the MKRN3 gene. They did not find any harmful changes in the kisspeptin (KISS1) gene, which is the peptide you asked about.
The study looked at whether giving GnRH to young girls changes their kisspeptin levels. It found no clear drop in kisspeptin after GnRH, and kisspeptin levels varied a lot between individuals. A possible link between kisspeptin and blood sugar was hinted but not proven.
Qasim. Mustafa M; Ricks-Santi. Luisel J LJ; Naab. Tammey J TJ; Rajack. Fareed F; Beyene. Desta D; Ab...
Researchers looked at two proteins, kisspeptin (KISS1) and its receptor (KISS1R), in breast tumors from African American women. They found that the cancer‑blocking protein KISS1 was higher in the aggressive triple‑negative type, while its receptor was lower, showing an opposite pattern. This suggests the kisspeptin system might play a role in how these cancers develop, but the study doesn’t give any direct advice for health‑hacking or everyday use.
Akkaya. Hatice H; Sümer. Engin E; Kutlu. Selim S; Solak. Hatice H; Yılmaz. Bayram B
In mice, giving kisspeptin-10 before a brief brain blood‑flow blockage changed brain chemistry and cell activity, but it didn't act as a strong antioxidant and the effects were modest and specific to the injury model.
Balraj. Premanand P; Ambhore. Nilesh Sudhakar NS; Ramakrishnan. Yogaraj S YS; Borkar. Niyati A NA; B...
A lab study found that a short piece of the hormone kisspeptin (kisspeptin‑10) can block the movement of airway smooth muscle cells that are stimulated by a growth factor, which could help reduce airway remodeling seen in asthma. The effect works through raising cAMP levels and activating a signaling cascade involving PKA and CREB, while lowering activity of proteins that drive cell movement.
Cichoń. Lena L; Janas-Kozik. Małgorzata M; Pałasz. Artur A; Wilczyński. Krzy...
Researchers measured three brain chemicals—phoenixin, spexin, and kisspein-10—in the blood of teens with bipolar disorder and compared them to healthy peers. They found lower phoenixin and higher spexin in the bipolar group, but kisspein-10 levels were about the same and not statistically different.
The paper describes a lab technique for spotting the KISS1 protein and its fragments (kisspeptins) in cells and the fluid they grow in. It’s useful for scientists who want to study how KISS1 is made and broken down, but it doesn’t give any direct advice on how to use kisspeptin‑10 for health or performance.
Arismendi. Daniel D; Alanis. Constanza C; Richter. Pablo P; Paredes. Alfonso H AH
In a short‑term study, female rats that ate triclosan (a common antibacterial chemical) grew less and had lower blood testosterone and progesterone, plus changes in some minerals. Their menstrual‑like cycle and kisspeptin‑10 levels stayed the same.
Musa. Ezekiel E; Salazar-Petres. Esteban E; Vatish. Manu M; Levitt. Naomi N; Sferruzzi-Perri. Amanda...
In pregnant South African women, having gestational diabetes didn't change the amount of kisspeptin or its receptor in the placenta, but obesity lowered the receptor's gene activity. Blood kisspeptin levels stayed the same regardless of obesity or diabetes, though they showed some links to placenta size and baby weight in specific sub‑groups. Overall, the study suggests that kisspeptin signaling in the placenta is subtly affected by maternal weight and diabetes, but it doesn't point to any clear way to use kisspeptin for health hacks.
The paper explains where kisspeptin (a peptide that helps start puberty and control reproductive hormones) is found in the brain and other tissues of various animals, and how it interacts with the hormone that triggers reproductive signals. It’s mostly basic science about animal biology, not about using kisspeptin in humans.
Scientists found that two drugs that change how genes are packaged (SAHA and AZA) can make lung cancer cells more sensitive to the chemotherapy drug cisplatin, and that adding the peptide kisspeptin‑10 (KP10) boosts this effect even more. The best results came when the gene‑changing drugs were given before cisplatin, and the combination also shrank tumors in mice.
Amodei. Rebecka R; Gribbin. Kyle K; He. Wen W; Lindgren. Isa I; Corder. Keely R KR; Jonker. Sonnet S...
This study shows that giving kisspeptin‑10 to fetal sheep triggers a surge of luteinizing hormone (LH) and later a rise in testosterone in male fetuses, confirming that kisspeptin can activate the reproductive hormone system before birth. The effect depends on the brain’s GnRH system and differs between sexes, but the work is done in unborn sheep, not adults, so it doesn’t give direct guidance for human use.
Panting. E N EN; Weight. J H JH; Sartori. J A JA; Coall. D A DA; Smith. J T JT
The study shows that kisspeptin, a hormone usually linked to reproduction, can slow down the movement of certain placenta cells in mice and human cell models. It doesn't change fetal or placental size, but it does affect genes tied to cell invasion and is linked to the mother's body weight.
Akdag. T T; Uca. A U AU; Altas. M M; Odabas. F O FO; Aktas. F F
Researchers measured a small protein called kisspeptin-10 in the blood of people with relapsing‑remitting multiple sclerosis (MS) and healthy volunteers. They found that MS patients had much lower levels of this protein, and the level could somewhat distinguish patients from healthy people. The study also noticed that lower kisspeptin-10 was linked to larger brain ventricle size and lower vitamin D, but it didn’t relate to most other disease measures.