Blasco. Victor V; Pinto. Francisco M FM; Fernández-Atucha. Ainhoa A; González-Ravina. Cris...
The study found that women with infertility have different levels of the kisspeptin gene (KISS1) and related neurokinin genes in the cells that surround the egg, compared to healthy egg donors. These differences were especially noticeable in older women, those with endometriosis, and women who respond poorly to ovarian stimulation.
In a goat study, the peptide kisspeptin-10 lowered the hormone progesterone and the levels of enzymes that make steroids, while it made luteal cells grow faster. The research was done in goat cells, not humans, and it didn’t show how to use kisspeptin for health or performance.
Abreu. Ana Paula AP; Toro. Carlos A CA; Song. Yong Bhum YB; Navarro. Victor M VM; Bosch. Martha A MA...
The study shows that a protein called MKRN3 acts like a brake on puberty by turning down the activity of kisspeptin and another hormone signal in the brain. When MKRN3 levels drop, the brake is released and puberty can start. Mutations that weaken MKRN3’s ability to tag other proteins also reduce this braking effect.
Valipour. AbdolMajid A; Heidari. Behrooz B; Vaziri. Hamidreza H; Asghari. S Mohsen SM
Injecting kisspeptin peptides into adult female goldfish boosted the activity of genes that control reproduction and led to more mature eggs, especially when using the human version of the peptide or a mix of fish and human peptides.
Mihajlovic. Milena M; Pekic. Sandra S; Doknic. Mirjana M; Stojanovic. Marko M; Miljic. Dragana D; So...
Researchers looked at whether the hormone kisspeptin and its receptor are present in pituitary tumors. They found kisspeptin is weakly present in most tumors, but the receptor KISS1R was not detected at all. The study doesn’t give any new tips on using kisspeptin for health or performance.
Smith. J T JT; Roseweir. A A; Millar. M M; Clarke. I J IJ; Millar. R P RP
In sheep, stopping the normal kisspeptin signal with special blockers caused a clear rise in growth hormone, while giving kisspeptin itself didn’t change hormone levels. The hormone‑producing cells in the pituitary have the kisspeptin receptor, indicating that the body’s own kisspeptin normally keeps growth hormone in check.
Li. Chao C; Yuan. Li L; Han. Shuangshuang S; Xuan. Mingda M; Liu. Dehua D; Tian. Bo B; Yu. Weifang W
The study found that lower levels of the protein Kiss-1 are linked to more aggressive stomach cancer, and that boosting Kiss-1 in cancer cells slows their growth and spread, while reducing it makes them more invasive.
Topaloglu. A Kemal AK; Simsek. Enver E; Kocher. Matthew A MA; Mammadova. Jamala J; Bober. Ece E; Kot...
Scientists found that rare changes in the NHLH2 gene can block the normal activation of the kisspeptin gene (KISS1), leading to delayed puberty and later‑life obesity. These gene variants also mess up the control of a brain receptor (MC4R) that regulates appetite. In short, NHLH2 is a key link between metabolism and the hormonal signals that start puberty.
Alkafaji. Haider A HA; Raji. Ahmed A; Rahman. Heshu S HS; Zekiy. Angelina O AO; Adili. Ali A; Jalili...
The study found that a tiny RNA molecule called Let-7i can boost the levels of a gene called KISS1, which makes kisspeptin proteins that help stop skin cancer cells from moving and growing. In lab experiments, adding Let-7i reduced cancer cell spread and caused them to die, while blocking KISS1 had the opposite effect.
Blasco. Victor V; Pinto. Francisco M FM; Fernández-Atucha. Ainhoa A; Prados. Nicolás N; Te...
The study found that women with polycystic ovarian syndrome have lower levels of the genes for kisspeptin and neurokinin B (and their receptors) in the cells that surround developing eggs, which may contribute to the abnormal follicle growth seen in PCOS.
Basini. G G; Grasselli. F F; Bussolati. S S; Ciccimarra. R R; Maranesi. M M; Bufalari. A A; Parillo....
Researchers found that the hormone‑like peptide kisspeptin and its receptor are present in pig ovarian cells and that adding kisspeptin‑10 in lab dishes increased progesterone production, boosted antioxidant activity, and may help grow new blood vessels in the ovary. The work is early‑stage and done in animals, so it doesn’t give clear instructions for people to use kisspeptin for health or performance yet.
Antar. Sarah S; Mokhtar. Naglaa N; Abd Elghaffar. Mahmoud Adel MA; Seleem. Amal K AK
Researchers looked at two gene variants—one in the NME1 gene and one in the KISS1 gene (which makes the kisspeptin peptide)—and found they are linked to a higher chance of getting breast cancer and, for the NME1 variant, a higher chance of the cancer spreading. The study does not test kisspeptin as a treatment, just shows a genetic association.
This short review explains that the KISS1 gene, which makes the peptide kisspeptin‑10, can be turned on or off by epigenetic changes caused by lifestyle and environment, and that these changes matter for fertility and cancer risk. It doesn’t give any new ways to use kisspeptin‑10, just highlights that epigenetics is an important factor in health.
Zhang. Xiaoyang X; Matziari. Magdalini M; Xie. Yixin Y; Fernig. David D; Rong. Rong R; Meng. Jia J;...
Scientists made a modified version of the kisspeptin-10 peptide that resists breakdown by enzymes that usually destroy it. One of these new peptides (called PKPR) can still turn on the kisspeptin receptor and also blocks an enzyme (MMP‑2) linked to cancer spread. However, this work is still at the early lab stage and not ready for any DIY or supplement use.
This paper reviews how changes (mutations) in the kisspeptin hormone and its receptor can cause puberty to start too early or too late, showing how important this system is for reproductive health. It mainly explains the biology and doesn’t give any direct tips on using kisspeptin for performance or longevity.
The study shows that a protein called Smurf1 is often higher in thyroid cancer cells and it helps break down another protein, kisspeptin‑1, which normally slows down cancer growth. When kisspeptin‑1 levels are increased, cancer cells grow less and die more, likely because it turns off a growth‑promoting pathway called NF‑κB. However, this research was done only in cell labs, not in people, so it doesn’t give clear guidance for health‑hacking or anti‑aging use.
Garcia. James P JP; Guerriero. Kathryn A KA; Keen. Kim L KL; Kenealy. Brian P BP; Seminara. Stephani...
In female rhesus monkeys, the study shows that the hormone‑like peptide kisspeptin‑10 and a related signal called neurokinin B both boost the release of GnRH, a hormone that starts puberty. Before puberty the two signals work independently, but once puberty begins they start to depend on each other. Blocking one signal stops the other from working in pubertal monkeys, but not in younger ones.
The study shows that a tiny protein called kisspeptin‑10 can make cow breast cells grow faster by turning on a receptor (GPR54) and several cell‑growth pathways. The effect was seen at a concentration of 100 nM in lab dishes, but the work was done only in cow cells, not in people.
The study looked at hormone levels in newborns during the first six months of life and found that kisspeptin and a protein called MKRN3 rise together while classic puberty hormones (LH, FSH, testosterone, estradiol) fall. Full‑term babies had higher levels of another hormone, neurokinin B, than pre‑term babies, but overall kisspeptin, MKRN3, and neurokinin B behaved similarly in boys and girls.
Amelkina. Olga O; Tanyapanyachon. Prattana P; Thongphakdee. Ampika A; Chatdarong. Kaywalee K
Scientists mapped the kisspeptin gene (Kiss1) in domestic cats and related wild cats, showing the peptide's structure is almost identical across these species and locating it in specific brain regions that control reproduction.