d'Anglemont de Tassigny. Xavier X; Jayasena. Channa N CN; Murphy. Kevin G KG; Dhillo. Waljit S WS; C...
The study shows that the longer version of kisspeptin (KP-54) stays in the blood much longer than the short version (KP-10) and can actually get into the brain, leading to a prolonged boost in the hormone LH. Repeated doses of KP-10 can't mimic this effect, suggesting KP-54 is the better choice for lasting reproductive hormone activation when taken peripherally.
George. J T JT; Veldhuis. J D JD; Roseweir. A K AK; Newton. C L CL; Faccenda. E E; Millar. R P RP; A...
Kisspeptin-10 is a tiny peptide that, when injected into men, quickly spikes the hormone LH, which in turn lifts testosterone levels. A single IV dose of about 1 µg per kg gives the strongest LH boost, while higher doses actually blunt the effect. Keeping a low‑dose infusion going for many hours further raises testosterone and makes LH pulses come more often and bigger.
Jayasena. C N CN; Nijher. G M K GM; Abbara. A A; Murphy. K G KG; Lim. A A; Patel. D D; Mehta. A A; T...
Giving kisspeptin-54 twice a week for eight weeks boosts the hormones that control ovulation in women who have stopped menstruating because their brain isn’t signaling properly, and it does so without causing side effects. Giving it twice a day quickly makes the body stop responding, but the less‑frequent schedule keeps the response mostly alive.
Jayasena. Channa N CN; Nijher. Gurjinder M K GM; Comninos. Alexander N AN; Abbara. Ali A; Januszewki...
Kisspeptin-10 makes the pituitary release the hormones LH and FSH in healthy men at very low IV doses, but in women it only works when given right before ovulation. During the early part of the menstrual cycle (follicular phase) it does nothing, even at much higher doses.
Dhillo. Waljit S WS; Chaudhri. Owais B OB; Thompson. Emily L EL; Murphy. Kevin G KG; Patterson. Mich...
Giving a single subcutaneous dose of kisspeptin‑54 to women makes their luteinising hormone (LH) spike, especially during the pre‑ovulatory part of the menstrual cycle. The effect grows with higher doses and is far stronger than a saline injection.
Kisspeptin is a natural hormone that sits at the top of the brain's reproductive control system. Giving kisspeptin to people can boost the release of other hormones that control fertility, and it can even jump‑start hormone rhythms in conditions like hypothalamic amenorrhea or certain genetic forms of low sex hormones. Researchers are now trying to turn kisspeptin or related drugs into treatments for menstrual problems, PCOS, and hot flashes.
Researchers found that the peptide kisspeptin-10 (Kp-10) can bind to a receptor called GPR54 on bone‑breaking cells (osteoclasts) and trigger a chain reaction that turns off a key enzyme (Src) that makes these cells over‑active. In mice lacking the receptor or related proteins, bones got weaker, but giving Kp-10 stopped the bone loss. This points to a new way to protect bone health by targeting the Kp-10/GPR54 pathway.
Kisspeptin‑10, a small hormone peptide, can stop joint‑cell (chondrocyte) aging caused by inflammation (TNF‑α) in lab dishes. It works by boosting a longevity protein called SIRT1 and turning off the aging signals p53/p21, which keeps the cells healthier and more able to repair cartilage.
Kadhem. Ali Hakem AH; Gholizadeh. Ashraf A; Khalaj-Kondori. Mohammad M
In Iraqi women with PCOS, taking metformin raised the hormone FSH and lowered the blood level of kisspeptin. A common genetic change in the KISS1 gene (G→C) was linked to a higher chance of PCOS and to a smaller rise in FSH after metformin. These results hint that both metformin and a person’s KISS1 genetics can influence reproductive hormone balance.
Sahin. Zafer Z; Aktas. Osman O; Kalkan. Omer Faruk OF; Cuce. Gokhan G; Alver. Ahmet A; Sahin. Elif E...
Giving kisspeptin to male rats by injection boosted the hormones that control reproduction (LH, FSH, testosterone) but didn’t trigger stress hormones. This shows kisspeptin can turn on the sex‑hormone system without activating the stress system, at least in rats.
Mills. Edouard G EG; Thurston. Layla L; Yang. Lisa L; Hunjan. Tia T; Phylactou. Maria M; Patel. Bija...
In a study where healthy men and women received an IV dose of kisspeptin, their reproductive hormone (LH) shot up, but there was no change in how anxious they felt, nor in stress hormones, blood pressure, or heart rate. This suggests kisspeptin can boost reproductive signaling without causing anxiety.
Romero-Ruiz. A A; Skorupskaite. K K; Gaytan. F F; Torres. E E; Perdices-Lopez. C C; Mannaerts. B M B...
Kisspeptin (KP-54) can boost reproductive hormones and even trigger ovulation in some animal models of PCOS and in a few women with the condition, but the effect is hit‑or‑miss and not strong enough to be a reliable DIY treatment yet.
Zhang. Yajie Y; Cao. Xinyuan X; Chen. Lin L; Qin. Yaoyao Y; Xu. Ye Y; Tian. Ying Y; Chen. Ling L
In mice, a chemical called PFOA (found in some household products) raises liver levels of a hormone called FGF21, which then suppresses kisspeptin in the brain and leads to messed‑up ovulation and longer non‑fertile cycles. Giving the mice a kisspeptin‑10 peptide (or blocking the FGF21 pathway) restores normal hormone spikes, ovulation, and cycle timing.
The paper explains that too much prolactin can shut down kisspeptin, a hormone that tells the brain to release reproductive hormones, leading to infertility. It also notes that kisspeptin can affect prolactin levels, suggesting a two‑way communication. This helps biohackers understand why high prolactin hurts fertility and points to possible ways to intervene, though no specific dosing advice is given.
Franssen. D D; Barroso. A A; Ruiz-Pino. F F; Vázquez. M J MJ; García-Galiano. D D; Castell...
In mice, the energy‑sensing enzyme AMPK in GnRH neurons normally dampens the reproductive hormone response when the body is low on fuel. Removing AMPK from these neurons makes female mice hit puberty earlier and react more strongly to kisspeptin‑10, a peptide that triggers LH release. The effect disappears if the ovaries are removed, showing the link depends on intact female reproductive organs.
Fabová. Zuzana Z; Loncová. Barbora B; Mlynček. Miloš M; Sirotkin. Alexander V...
The study shows that human ovarian cells make kisspeptin and its receptor, and that a low amount of kisspeptin (10 ng/mL) helps these cells stay alive, multiply, and release key hormones, while a high amount (100 ng/mL) does the opposite and even blocks the normal actions of FSH, a hormone important for fertility.
Fabová. Zuzana Z; Loncová. Barbora B; Mlyn Ek. Miloš M; Sirotkin. Alexander V AV
The study shows that kisspeptin-10 can boost ovarian cell health at low concentrations (1‑10 ng/mL) by increasing cell survival, growth, and hormone production, while a high dose (100 ng/mL) does the opposite. It also reveals that kisspeptin can block the hormone‑driven release of another growth factor (AREG) that FSH normally stimulates.
Millar. Robert P RP; Sonigo. Charlotte C; Anderson. Richard A RA; George. Jyothis J; Maione. Luigi L...
In two women with high prolactin levels that caused loss of periods and who didn't respond to standard medication, a short infusion of the peptide kisspeptin-10 jump‑started their reproductive hormone signals and raised estrogen, testosterone and other ovarian markers, showing the hormone axis could be re‑activated.
Skorupskaite. Karolina K; George. Jyothis T JT; Veldhuis. Johannes D JD; Millar. Robert P RP; Anders...
In a tiny study of six healthy men, blocking the NK3 receptor lowered the body's natural production of LH, FSH, and testosterone, but a single dose of kisspeptin‑10 still caused a spike in LH even while the blocker was active. This shows the NK3 pathway sits upstream of kisspeptin in controlling reproductive hormones.
Gibula-Tarlowska. Ewa E; Grochecki. Pawel P; Silberring. Jerzy J; Kotlinska. Jolanta H JH
A new peptide called kissorphin, which is similar to kisspeptin-10, was given to rats and was found to block the rewarding feeling they get from alcohol. It stopped the rats from learning to like places associated with alcohol, reduced the feeling of reward when they were already conditioned, and prevented a relapse after a break. The peptide didn't cause any preference or aversion on its own and didn't affect the rats' movement or coordination.