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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Colledge. W H WH
Kisspeptin-10 (and its longer relatives) binds to the GPR54 receptor and triggers the brain to release GnRH, which then boosts the sex hormones LH and FSH. This pathway is essential for puberty and fertility, and it can be influenced by sex steroids and metabolic signals like leptin. While the study shows how kisspeptin can jumpâstart the reproductive axis in animals, it doesnât give dosing or safety details for human use.
Seminara. Stephanie B SB; Dipietro. Meloni J MJ; Ramaswamy. Suresh S; Crowley. William F WF; Plant....
In monkeys, a single dose of kisspeptin-10 (metastin 45â54) quickly raises LH, but keeping the peptide flowing continuously makes the receptor stop working, causing LH to crash. The downstream hormone system still works, so the drop is due to the receptor itself becoming desensitized. This shows that continuous kisspeptin can shut down the reproductive hormone axis, similar to how GnRH drugs are used clinically.
Hauge-Evans. A C AC; Richardson. C C CC; Milne. H M HM; Christie. M R MR; Persaud. S J SJ; Jones. P...
The study shows that the hormone kisspeptin is made in the pancreas and can boost insulin release when blood sugar is high, but it doesnât change insulin when sugar is low. In lab-grown beta cells, kisspeptin actually lowered insulin, and it didnât affect glucagon (the hormone that raises blood sugar). This suggests kisspeptin may help fineâtune insulin spikes after meals.
Tissen. I I; Magarramova. L L; Badrutdinov. R R; Takeeva. Z Z; Proshin. S S; Shabanov. P P
In rats, giving kisspeptin-10 through the nose boosted sexual interest without raising testosterone, while injecting it raised both testosterone and sexual interest. This shows kisspein can affect libido through a pathway that doesnât rely on testosterone.
Dhillo. Waljit S WS; Murphy. Kevin G KG; Bloom. Stephen R SR
Kisspeptin-10 is a short protein that can turn on the bodyâs reproductive hormone system. In healthy men, a single IV dose quickly raised LH, FSH and testosterone without obvious side effects. The peptide is also naturally high during pregnancy and may serve as a marker for certain placental tumors.
Murphy. K G KG
Kisspeptin-10 is a natural peptide that talks to a brain receptor (GPR54) and can turn on the reproductive hormone system, raising levels of LH and FSH. It was first found as a gene that blocks cancer spread, but now we know it mainly helps control puberty and fertility. Giving kisspeptin (either into the brain or the bloodstream) quickly boosts these hormones in animals, and the system is tuned by the body's own sex hormones.
de Roux. Nicolas N
The paper explains that problems with the GnRH receptor or its partner GPR54 can cause a rare condition where the body doesn't make enough reproductive hormones. Kisspeptin (the natural ligand for GPR54) can boost LH and FSH by influencing GnRH release or how the pituitary responds. These findings help us understand how puberty starts and why some people have hormone deficiencies.
Ramaswamy. Suresh S; Seminara. Stephanie B SB; Pohl. Clifford R CR; DiPietro. Meloni J MJ; Crowley....
In adult male rhesus monkeys, giving kisspeptin-10 (metastin 45â54) continuously through an IV caused a quick spike in the hormone LH, but after a few hours the LH levels fell back to normal because the receptor got desensitized. Surprisingly, even when LH was low, testosterone stayed higher than usual, hinting that kisspeptin might act directly on the testes.
Santos. Luciano Cardoso LC; Dos Anjos Cordeiro. Jeane Martinha JM; da Silva Santana. Larissa L; Barb...
In male rats made hypothyroid, giving the peptide kisspeptin-10 helped bring back normal testicle size, sperm quality, and hormone levels. It lowered the unusually high prolactin and raised LH and testosterone, essentially fixing the damage caused by low thyroid hormone.
Santos. Luciano Cardoso LC; Dos Anjos Cordeiro. Jeane Martinha JM; Cunha. Maria Clara da Silva Galr&...
In rats with low thyroid hormone, giving kisspeptinâ10 helped protect the testes from oxidative damage and reduced cell death, but it didnât fix the stressâprotein pathway that was also messed up by the thyroid problem.
Santos. Bianca Reis BR; Dos Anjos Cordeiro. Jeane Martinha JM; Santos. Luciano Cardoso LC; Barbosa....
In pregnant rats with low thyroid hormone, giving the peptide kisspeptinâ10 every day helped the babies grow bigger and protected the placenta from oxidative damage. The treatment boosted several growthâfactor genes and antioxidant enzymes in the placenta, but it didnât fix all the hormoneârelated changes caused by hypothyroidism.
Sridhar. Ananyaa A; Khan. Dawood D; Muthukumar. Rithiga R; Sampathkumar. Swetha S; Irwin. Nigel N; F...
In a mouse study, giving kisspeptin-10 twice daily for three weeks lowered body weight, blood sugar, and food intake in highâfatâdiet females, making them look like mice on a normal diet. It also changed gut hormoneâproducing cells and boosted the growth of insulinâproducing beta cells in the pancreas, without harming the cells.
Li. Jianhua J; Chen. Jinhuan J; Lu. Lin L; Gan. Bei B
In a rat model of gestational diabetes, the peptide kisspeptin-10 helped lower blood sugar and improve insulin sensitivity by turning on a cell signaling pathway (cAMP/PKA) that boosts glucose uptake in placental cells. The effect vanished when the pathway was blocked, showing itâs essential for the benefit.
Simon. Christopher C; Soga. Tomoko T; Parhar. Ishwar I
In a lab study, the short peptide kisspeptinâ10 (KPâ10) helped protect humanâderived nerve cells from dying when they were overloaded with a protein called alphaâsynuclein, which is linked to Parkinsonâlike damage. The protection happened even when the usual kisspeptin receptor was blocked, suggesting KPâ10 works through a different, unknown pathway.
Serhatlioglu. Ihsan I; Kacar. Emine E; Yardimci. Ahmet A; Ulker Ertugrul. Nazife N; Bulmus. Ozgur O;...
In male rats, a short piece of the hormone kisspeptin (kisspeptinâ10) made them act less depressed in a swimming test. This moodâlifting effect disappeared when a blocker of the kisspeptin receptor (peptide 234) was given, and it also relied partly on certain adrenaline and serotonin receptors.
Wang. Gengfu G; Xu. Geng G; Zhang. Chao C; Han. Azhu A; Zhang. Guobao G; Chen. Liru L; Xie. Guodie G...
The study shows that when pregnant mice are exposed to the chemical bisphenol A (BPA) early or midway through pregnancy, their female babies hit puberty earlier. This early puberty is linked to higher levels of the hormoneâlike peptide kisspeptinâ10 and changes in brain gene regulation.
Mattar. Dareen D; Cheewasopit. Warakorn W; Samir. Moafaq M; Knight. Philip G PG
Researchers looked at whether kisspeptin-10 can directly change hormone production in cow ovarian cells. They found the peptide and its receptor are present, but adding kisspeptin or a blocker didnât change steroid hormone levels or cell survival. So, kisspeptin doesnât seem to act locally in the ovary to affect hormone output.
Parkpinyo. Nichamon N; Anekpornwattana. Sirichet S; Sitticharoon. Chantacha C; Petyim. Somsin S
The study found that men with infertility had higher levels of kisspeptin in their blood compared to fertile men, while kisspeptin levels in semen didnât differ much. This suggests blood kisspeptin could be a useful marker for spotting male infertility, but it doesnât tell us how to treat it yet.
Babey. Muriel E ME; Krause. William C WC; Chen. Kun K; Herber. Candice B CB; Torok. Zsofia Z; Nikkan...
The study found that a brain hormone called CCN3, released from kisspeptinâproducing neurons during lactation, helps build bone by activating skeletal stem cells. When CCN3 was reduced, mother mice lost bone and could not support their pups on a lowâcalcium diet. This points to CCN3 as a possible new boneâbuilding signal for both sexes.
Szysiak. Natalia N; Kosior-Korzecka. Urszula U; Longo. Vincenzo V; Patkowski. Krzysztof K; Gregu...
In a lab study using cells taken from young sheep, the researchers found that the peptide kisspeptinâ10, as well as neurokinin B and dynorphin A, can directly boost the release of the reproductive hormones LH and FSH from the pituitary gland. The effect was seen at very low (10â»ÂčÂčâ10â»âžâŻM) concentrations for kisspeptinâ10 and across a broader range for the other two peptides. While this shows the peptides can act straight on the pituitary, the work was done in sheep cells and not in people.