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Kisspeptin-10

KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1

Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.

Quick Stats
Studies 877
Trials 47
Formula C63H83N17O14
Overview Studies 877 Clinical Trials 47
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pubmed 2003

Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome.

Sanchez-Carbayo. Marta M; Capodieci. Paola P; Cordon-Cardo. Carlos C

The study shows that the protein made from the KiSS-1 gene (kisspeptin) is often missing in aggressive bladder cancers, and patients whose tumors lack KiSS-1 tend to have poorer survival. This suggests KiSS-1 may help keep bladder cells from turning cancerous, but the research does not test taking kisspeptin as a supplement or therapy.

pubmed 2004

Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression.

Hesling. Cédric C; D'Incan. Michel M; D'Incan. Chantal C; Souteyrand. Pierre P; Monboisse. Jean...

The study looks at how lowering BRCA1 levels in melanoma cells makes them more sensitive to radiation and changes some genes linked to blood vessel growth and metastasis. It does not involve kisspeptin-10 or any peptide that biohackers could use, and it focuses on cell‑culture experiments rather than practical health protocols.

pubmed 2005

[Expression and significance of KiSS-1 and its receptor GPR54 mRNA in epithelial ovarian cancer].

Zhang. Shu-lan SL; Yu. Yi Y; Jiang. Tao T; Lin. Bei B; Gao. Hong H

The study measured the amount of the kisspeptin gene (KiSS‑1) and its receptor GPR54 in ovarian tissue samples. KiSS‑1 was higher in cancerous and borderline tumors and rose with later stage and lymph‑node spread, while GPR54 levels were similar across normal, benign, and cancerous tissues. The authors suggest KiSS‑1 may help suppress early tumor invasion, but no treatment was tested.

pubmed Oct 15, 2001

Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23.

Shirasaki. F F; Takata. M M; Hatta. N N; Takehara. K K

The study shows that the KiSS1 gene, which can suppress tumor spread, is turned off more often as melanoma gets thicker and spreads, and this loss is linked to a specific chromosome region being missing. It’s a cancer‑research finding, not a guide for using kisspeptin‑10 as a health supplement.

pubmed 2012

KISS1/KISS1R expression in eutopic and ectopic endometrium of women suffering from endometriosis.

Makri. A A; Msaouel. P P; Petraki. C C; Milingos. D D; Protopapas. A A; Liapi. A A; Antsaklis. A A;...

Researchers checked whether the kisspeptin system (KISS1 and its receptor KISS1R) is present in uterine tissue of women with endometriosis. They found the receptor in about half of the normal‑looking uterine samples from these women, but not in the endometriosis lesions or in tissue from women without the disease. The kisspeptin peptide itself wasn’t detected anywhere, suggesting any receptor activity might come from kisspeptin produced elsewhere in the body.

pubmed Jan 15, 2003

Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP.

Goldberg. Steven F SF; Miele. Mary E ME; Hatta. Naohito N; Takata. Minoru M; Paquette-Straub. Carrie...

Scientists discovered that a region on chromosome 6 helps stop melanoma cancer cells from spreading by turning on two other genes, KISS1 and TXNIP, which act as metastasis suppressors. They also found that a protein called CRSP3 on chromosome 6 can boost these genes and reduce metastasis. The work is mainly about cancer biology, not about using kisspeptin-10 as a health supplement.