Blake. Alexandra A; Dragan. Magdalena M; Tirona. Rommel G RG; Hardy. Daniel B DB; Brackstone. Muriel...
The study found that a protein called KISS1R, which normally binds kisspeptin peptides, is higher in aggressive triple‑negative breast cancer and helps the cancer resist chemotherapy by boosting drug‑pumping proteins and another growth‑factor receptor. Blocking KISS1R might make these tumors more sensitive to treatment, but the research is still at the early, lab‑based stage.
Gosiewski. Grzegorz G; Sokolowska-Mikolajczyk. Miroslawa M; Chyb. Jaroslaw J; Socha. Magdalena M
Scientists tested human kisspeptin on female Prussian carp and found it didn’t change the fish’s natural LH hormone levels on its own, but it could tweak LH when mixed with other hormones or dopamine blockers. The results are about fish reproduction, not human health.
Paré-Brunet. L L; Sebio. A A; Salazar. J J; Berenguer-Llergo. A A; Río. E E; Barnadas. A A...
The study examined DNA variations in the VEGF pathway, including a gene called KISS1, to see if they could predict how well patients with metastatic colorectal cancer respond to a specific chemotherapy regimen. It found some genetic markers linked to survival outcomes, but it does not provide any guidance on using kisspeptin-10 or related interventions for health optimization.
Whitehead. Clare L CL; McNamara. Helen H; Walker. Susan P SP; Alexiadis. Maria M; Fuller. Peter J PJ...
Researchers found that tiny pieces of RNA from the placenta can be detected in a pregnant woman's blood around 28 weeks and that certain RNA patterns can predict if the baby will be small at birth. This is a diagnostic discovery for pregnancy complications, not a therapy or lifestyle intervention.
Chen. L L; Liu. M M; Ji. J J; Lin. W W; Shan. F F; Liu. H H
The study looked at whether measuring kisspeptin mRNA and the cancer marker CA125 in blood can help spot ovarian cancer in women who have been pregnant before. It found both markers can detect cancer, but the combination works best for overall detection, not specifically for early or advanced stages.
Yin. Yiran Y; Tang. Lian L; Shi. Lei L
The expression of the metastasis suppressor gene KISS-1 in osteosarcoma cells during apoptosis and autophagy was evaluated. MG-63 osteosarcoma cells were transfected with either KISS-1 overexpression or KISS-1 knockdown expression vector in vitro, and compared with cell lines transfected with empty vector. After 12, 24, 48 and 72 h of cell culture, the cell proliferation was examined. The MTT method was used to detect apoptosis by flow cytometry, and the mRNA levels of apoptosis and autophagy markers caspase-3, Bcl-2, Bax, LC3 and Beclin1 were assessed by RT-PCR. Our results showed that cells in the control and low expression group kept proliferating during the cell culture period of 72 h, while the cells in the overexpression group progressively decreased in number. Also, the proliferation rate of the low expression group was significantly higher than that of the control group. The relative mRNA expression levels of caspase-3 and Bax mRNA in the control and low expression group showed no change (the expression was lowest in the low expression group). Moreover, the mRNA level of Bcl-2 increased in both cell groups. The mRNA expression levels of caspase-3 and Bax in the overexpression group were increased, and the level of Bcl-2 was reduced significantly. At the same time, the relative expression level of LC3 and Beclin1 mRNA in the control and low expression groups remained the same, and that of the overexpression group increased. The mRNA levels of LC3 and Beclin1 in the overexpression group were the highest, and that of the low expression group the lowest. The differences were statistically significant (P<0.05). Based on these results, we showed that KISS-1 inhibited the proliferation of osteosarcoma in vitro, probably by accelerating the processes of apoptosis and autophagy in the cells.
Zhang. Yu Y; Huang. Zhen Z; Zhu. Zhiqiang Z; Zheng. Xin X; Liu. Jianwei J; Han. Zhiyou Z; Ma. Xuetao...
The research shows that a protein called UHRF1 is higher in bladder cancer and it turns off the KiSS1 gene, which normally helps stop cancer from spreading. When KiSS1 is silenced, cancer cells become more invasive. This is a basic cancer‑biology finding and doesn’t give any direct tips or protocols for health‑optimizing or anti‑aging use.
Whitehead. Clare L CL; Walker. Susan P SP; Ye. Louie L; Mendis. Sonali S; Kaitu'u-Lino. Tu'uhevaha J...
Scientists found that a set of genes that are normally active only in the placenta, including the KISS1 gene that makes kisspeptin, show abnormal levels in the blood of pregnant women whose babies have severe growth problems. This suggests these placental RNAs could become a blood test for early detection of fetal growth restriction, but it doesn’t give any direct advice for health‑hacking or personal use of kisspeptin.
Shen. Zhan-Long ZL; Wang. Bo B; Jiang. Ke-Wei KW; Ye. Chun-Xiang CX; Cheng. Cheng C; Yan. Yi-Chao YC...
The study found that a tiny RNA called miR-199b is lower in colorectal cancer that has spread to the liver. This loss lets a protein called SIRT1 become more active, which then shuts down the KISS1 gene (the source of the kisspeptin peptide) through a chain involving the CREB factor. Raising miR-199b levels or blocking SIRT1 reduced cancer cell spread and made chemotherapy work better, but the work is limited to cancer cells in the lab and mice.
Taylor. Jay J; Pampillo. Macarena M; Bhattacharya. Moshmi M; Babwah. Andy V AV
The study shows that kisspeptin, a hormone known for regulating reproductive hormones, makes certain placenta cells stick more strongly to a protein called collagen, and it does this through specific cell signaling pathways. This effect is quick, temporary, and depends on activating PKC and ERK proteins. The findings are mainly about early pregnancy and implantation, not about general health or performance.
Qureshi. Irfan Zia IZ; Abbas. Qamar Q
The present study investigated the role of kisspeptin-10 on reproductively significant trace elements in relation to testosterone release in male rabbits, Oryctolagus cuniculus. Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspeptin antagonist, peptide-234 (50 μg) 20 min before administering kisspeptin. Sequential blood sampling was done through marginal ear vein puncture at staggered time intervals: 0, 0.5, 1, 2, 4, and 24 h to determine serum testosterone. Testes and whole blood were collected at 4 and 24 h post dosage to determine trace element concentrations through atomic absorption spectrophotometry. In testes, zinc (Zn), manganese (Mn), and Fe concentrations showed significant increases at 24 h, while copper (Cu) concentration was found elevated at 4 and 24 h both (P < 0.001). In whole blood, Zn and Cu concentrations were significantly elevated at 4 and 24 h, while Mn and cobalt (Co) concentrations showed increases only at 24 h (P < 0.001). Blood iron concentration was not altered in the blood. In contrast, no change occurred in testicular Co, and chromium or nickel concentrations in either testes or blood. Compared to control and predose groups, serum testosterone levels increased gradually and peaked at 2 h (P < 0.001) post kisspeptin treatment but declined thereafter. Pretreatment with antagonist abolished all increases in trace elements and testosterone concentrations. The present study provides first evidence that reproduction- and fertility-related peptide "kisspeptin" modulates testicular and blood trace elements and that this action is likely GPR54-dependent.
Rhie. Young-Jun YJ; Lee. Kee-Hyoung KH; Ko. Jung Min JM; Lee. Woo Jung WJ; Kim. Jung Hyun JH; Kim. H...
Researchers looked at variations in the KISS1 gene, which makes the hormone kisspeptin, in Korean girls who started puberty unusually early. They found several genetic differences, including a new one, that were more or less common in the early‑puberty group, suggesting these gene changes might influence when puberty begins. However, the study doesn’t test kisspeptin as a supplement or give any advice for adult health or performance.
Yaron. Marianna M; Renner. Ulrich U; Gilad. Suzan S; Stalla. Günter K GK; Stern. Naftali N; Gre...
Researchers examined pituitary tumors and found that the kisspeptin receptor (KISS1R) is common in non‑functioning tumors, especially in women and older patients, but it doesn’t change tumor size or aggressiveness, offering no direct health‑hacking advice.
Selvaraj. Sethu S; Kitano. Hajime H; Ohga. Hirofumi H; Yamaguchi. Akihiko A; Matsuyama. Michiya M
The study looked at how certain brain chemicals (kisspeptins and related hormones) change as young chub mackerel grow and develop male or female organs. It found that these chemicals are most active early in life and show different patterns in males and females during the sex‑differentiation stage.
Liu. Wen W; Beck. Benjamin H BH; Vaidya. Kedar S KS; Nash. Kevin T KT; Feeley. Kyle P KP; Ballinger....
Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis decreases and oxidative phosphorylation predominates. However, when KISS1 is missing the secretion signal peptide (ΔSS), invasion and metastasis are no longer suppressed and cells continue to metabolize using aerobic glycolysis. KISS1-expressing cells have 30% to 50% more mitochondrial mass than ΔSS-expressing cells, which are accompanied by correspondingly increased mitochondrial gene expression and higher expression of PGC1α, a master coactivator that regulates mitochondrial mass and metabolism. PGC1α-mediated downstream pathways (i.e., fatty acid synthesis and β-oxidation) are differentially regulated by KISS1, apparently reliant upon direct KISS1 interaction with NRF1, a major transcription factor involved in mitochondrial biogenesis. Since the downstream effects could be reversed using short hairpin RNA to KISS1 or PGC1α, these data appear to directly connect changes in mitochondria mass, cellular glucose metabolism, and metastasis.
Wang. Jun J; Sun. Lei L; Zhang. Tao T; Zhou. Haizhu H; Lou. Yujie Y
Scientists gave a peptide called kisspeptin‑10 to young female sheep and saw that it caused a rapid rise in the reproductive hormone LH, both after a single shot and after several shots given one hour apart. The effect was bigger with higher doses, but the study was done only in pre‑pubertal ewes, not humans.
Dillenburg-Pilla. Patricia P; Maria. Andrea G AG; Reis. Rosana I RI; Floriano. Elaine Medeiros EM; P...
A mouse study found that turning on a specific protein called the kinin B1 receptor slowed down melanoma tumor growth and reduced spread, but this work does not involve kisspeptin-10 and has no direct advice for human health or performance.
Matjila. Mushi M; Millar. Robert R; van der Spuy. Zephne Z; Katz. Arieh A
This study looked at where the kisspeptin gene (Kiss1) and related proteins are turned on in the placenta and surrounding maternal tissues during a healthy pregnancy. It found that kisspeptin and its receptor are most active in the fetal side of the placenta, while different blood‑vessel growth signals dominate on the maternal side. The work helps scientists understand how the baby and mother coordinate blood‑vessel formation, but it doesn’t give any tips you can use for health, performance, or longevity outside of pregnancy.
Zhang. Hui H; Guo. Yan Y; Shang. Chao C; Song. YongSheng Y; Wu. Bin B
The study looked at kidney cancer cells and found that a small RNA called miR‑21 is higher in tumors, which then lowers two proteins, TCF21 and KISS1. Lower KISS1 makes the cancer cells more invasive, while adding extra KISS1 reduces their ability to spread. This work is about cancer biology, not about using kisspeptin‑10 as a supplement or health tool.
Yuan. Tai-Ze TZ; Zhang. Huan-Huan HH; Tang. Qiong-Fen QF; Zhang. Qiong Q; Li. Jian J; Liang. Yin Y;...
Researchers looked at the protein kisspeptin in tissue samples from people with nasopharyngeal cancer. They found that patients whose tumors had low levels of kisspeptin tended to have more advanced disease and a higher chance of the cancer spreading, but this doesn't tell us how to use kisspeptin for health or performance.