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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Loncová. Barbora B; Fabová. Zuzana Z; Sirotkin. Alexander V AV
The study looked at how two proteins, kisspeptin-10 and betacellulin, affect ovarian cells taken from cats. Kisspeptin-10 made the cells grow more, die more, and release more female hormones, while betacellulin did the opposite and also blocked kisspeptin's effects. The research was done in a lab setting on cat tissue, not on people.
Chen. Lingna L; Ruan. Yuying Y; Ni. Liping L; Wang. Guiting G; Gao. Yajuan Y; Zhang. Jindi J; Li. Di...
This study looked at a protein called kisspeptin (KISS-1) in cells that line the placenta and found that changing its levels can affect how those cells grow and move. The research is focused on why some women have repeated miscarriages, not on general health, fitness, or aging.
Günday. Özlem Kayacık ÖK; Vurmaz. Ayhan A; Yılmazer. Mehmet M
Researchers measured kisspeptin‑10 in the first trimester of pregnancy and found that higher levels were linked to a higher chance of the baby having growth problems later, but the test isn’t strong enough to be used as a routine health hack.
Lv. Jiyang J; Zhang. Junya J; Wu. Fangfang F
The study looked at levels of the protein kisspeptin (KiSS‑1) and an enzyme called MMP‑2 in breast cancer tissue from older women who had surgery. It found that lower kisspeptin and higher MMP‑2 (and CEA) were linked to worse outcomes, and together they could predict prognosis fairly well. This information is about cancer prognosis, not about everyday health hacks or longevity, so it isn’t directly useful for biohackers.
Cao. Yu Y; Hu. Guiqiu G; Zhang. Qing Q; Ma. Lijun L; Wang. Jiaxin J; Li. Wen W; Ge. Yusong Y; Cheng....
The study shows that a peptide called kisspeptin‑10 can increase milk protein and fat production in cow mammary cells by turning on the mTOR pathway and blocking a protein called SIRT6, but it was done only in isolated cow cells, not in people.
Kuspinar. Goktan G; Cakır. Cihan C; Kasapoglu. Isıl I; Saribal. Seda S; Oral. Barbaros B...
The study looked at whether kisspeptin or its receptor in the fluid around human eggs predicts egg maturation, and found no link – the levels were the same regardless of whether eggs were mature or not.
Li. Yunwei Y; Zhang. Huifeng H; Li. Qiang Q; Huang. Xinwei X; Kong. Xiangyang X
The study examined how certain gene variants (including in the KISS1 gene) are linked to early, fast puberty in Chinese girls and found that some variants affect hormone levels, but it does not provide any guidance on using kisspeptin‑10 for health or performance in adults.
Meng. Fanting F; Zhao. Aiqin A; Lu. Haiying H; Zou. Dan D; Dong. Bei B; Wang. Xiaoqing X; Liu. Li L;...
The study looked at three small changes (SNPs) in the KISS1 gene and found that two of them (rs12998 and rs4889) are linked to a higher chance of unexplained recurrent pregnancy loss in women, while the third (rs35431622) showed no link. Certain combinations of these gene variants (haplotypes) were also associated with the condition.
Nie. Yaoyan Y; Wei. Yanzhu Y; Zhang. Yuhuan Y; Liang. Zhuansheng Z; Lei. Zelin Z; Chang. Min M; Peng...
Researchers attached a short kisspeptin peptide (Kp-10) to liposomes carrying the chemotherapy drug doxorubicin, aiming to target breast cancer cells that have high levels of the GPR54 receptor. In mice, these targeted liposomes accumulated more in tumors and improved survival compared to non‑targeted liposomes or free drug. The study shows a new way to deliver cancer drugs, but it does not provide any direct advice or protocols for personal health optimization.
Ruiz. Aidet A; Ramos. Luis L
A small Mexican study looked at DNA changes in the kisspeptin‑related KNDy pathway to see if they cause early ovarian failure. They found a few genetic variants, but these were just as common in healthy women, meaning the variants probably don’t cause the condition. So testing these genes isn’t helpful for diagnosing or treating early ovarian loss.
Dong. Lijuan L; Zhou. Weiguang W; Lin. Zhongchao Z; Tang. Lingyu L; Deng. Xinyi X; Chen. Bifeng B; H...
Researchers looked at three genetic variants in the KISS1 gene and found that two of them (rs5780218 and rs12998) are linked to a higher chance of early puberty in Chinese girls, while certain combinations of these variants can either raise or lower that risk.
Wu. Peng P; Liu. Shanshan S; Xu. Tingting T; Zhao. Guoliang G
The study found that the hormone-like peptide kisspeptin can slow down the growth of eye cells that cause a common eye problem called pterygium, mainly by lowering certain inflammation‑related signals. Adding back those signals makes the cells grow faster again.
Qin. Y S YS; Bai. J H JH; Zhang. S L SL; Dai. J G JG; Xu. X L XL; Feng. T T; Song. Y Q YQ; Xiao. L L...
In a study on 198 weaned sows, giving a low dose (0.5 mg) of the peptide kisspeptin‑10 96 hours after weaning didn’t change whether the animals went into heat or got pregnant, but it made the heat period a bit longer and caused a slightly bigger hormone (LH) spike compared to the standard GnRH injection.
Katirci. Yunus Y; Kocaman. Adem A; Ozdemir. Ayse Zehra AZ
The study measured kisspeptin (KISS1) levels in pregnant women with placenta previa and found that these women had much lower KISS1 protein and gene expression in their blood and placenta, while the receptor for KISS1 was dramatically higher. The researchers suggest this drop in KISS1 might be linked to why placenta previa occurs, but they did not test any interventions.
Al-Kaabi. Maysoun A MA; Hamdan. Farqad B FB; Al-Matubsi. Hisham H
The study measured a hormone called kisspeptin-10 in pregnant women and found that levels are lower in those who develop preeclampsia, a pregnancy‑related blood‑pressure problem. While the hormone shows some link to other pregnancy hormones, the test isn’t reliable enough to be used as a routine screening tool.
Bollino. Arianna A; Cangiano. Biagio B; Goggi. Giovanni G; Federici. Silvia S; Duminuco. Paolo P; Gi...
The paper explains how doctors struggle to tell the difference between a normal, temporary delay in puberty and a permanent hormonal problem, because both look the same at first. It reviews the tests that can help make the right diagnosis, but it doesn’t give any tips that biohackers could use for health optimization.
Kapustin. R V RV; Drobintseva. A O AO; Alekseenkova. E N EN; Onopriychuk. A R AR; Arzhanova. O N ON;...
The study looked at how the protein kisspeptin‑1 and its receptor are expressed in placentas from pregnancies that had diabetes, preeclampsia, or both. It found higher levels of these proteins in placentas from preeclamptic and diabetic pregnancies, and that higher kisspeptin‑1 was linked to preeclampsia and lower baby birth weight. The research is specific to pregnancy and does not give guidance for using kisspeptin‑10 in everyday health or performance.
Hasegawa. Koki K; Maedomari. Rika R; Sato. Younosuke Y; Gotoh. Kumiko K; Kudoh. Shinji S; Kojima. Ak...
The study describes a new lab technique that uses a fluorescent version of kisspeptin to spot its receptor (Kiss1R) in cells and tissues, bypassing the need for antibodies. It’s a methodological advance for researchers, not a health‑oriented finding.
Li. Di D; Wu. Yu Y; Cheng. Jinquan J; Liu. Liegang L; Li. Xiaoheng X; Chen. Dingyan D; Huang. Suli S...
The study looked at genetic variations in the kisspeptin signaling pathway and how they relate to early puberty in Chinese girls. It found that certain gene changes increase the chance of early puberty, while another change may protect against it. The research does not provide any guidance on using kisspeptin‑10 or related compounds for health, performance, or longevity.
Duan. Houyu H; Ding. Xiang X; Luo. Hesheng H
The study shows that the gene KISS-1, which makes the peptide kisspeptin, is often turned off in esophageal cancer because its DNA promoter gets too many methyl groups. Restoring KISS-1 reduces cancer cell spread by lowering enzymes (MMP2/9) and signaling pathways (ERK, p38 MAPK) that help tumors move.