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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Clarkson. Jenny J; Herbison. Allan E AE
Scientists mapped where kisspeptin cells live in mouse brains and how they grow after birth. They found three groups of these cells, with a lot more in a specific brain area of females. The cells appear around the time of puberty and connect to the hormone‑releasing cells that control reproduction.
Castellano. J M JM; Navarro. V M VM; Fernández-Fernández. R R; Castaño. J P JP; Malag...
In rats, a short form of the hormone kisspeptin (kisspeptin‑10) can trigger the brain's release of GnRH and the downstream hormone LH, even before puberty. The response gets a bit stronger around puberty, and the effect relies on specific cell signaling pathways (PLC, calcium, ERK1/2, p38). The study is basic science and doesn’t test humans or give dosing advice.
Plant. Tony M TM
The abstract talks about using male monkeys to study how puberty starts in humans, focusing on brain mechanisms, but it doesn’t give any direct tips or dosage info for using kisspeptin‑10 in everyday health hacks.
Revel. Florent G FG; Saboureau. Michel M; Masson-Pévet. Mireille M; Pévet. Paul P; Mikkels...
The paper explains that a gene called KiSS-1 makes a protein (kisspeptin) that can turn on the brain’s hormone system that controls reproduction, and it might help animals sync breeding with the right season by working with melatonin signals.
Katagiri. Fumihiko F; Tomita. Kenji K; Oishi. Shinya S; Takeyama. Masaharu M; Fujii. Nobutaka N
Scientists made a test to measure kisspeptin (called metastin) and LHRH in blood. In a man with a hormone deficiency, LHRH was very high but kisspeptin levels looked normal, like in healthy people. This hints that kisspeptin in the bloodstream might act differently than the brain version, but the study doesn’t give any clear ways to use it for health hacks.
Hata. Kohkichi K; Dhar. Dipok Kumar DK; Watanabe. Yoh Y; Nakai. Hidekatsu H; Hoshiai. Hiroshi H
The study looked at the levels of a protein called metastin (kisspeptin-10) and its receptor AXOR12 in ovarian cancer tissue and found that lower amounts were linked to more aggressive tumors and worse patient outcomes, while higher levels were associated with better prognosis.
Orsini. Michael J MJ; Klein. Mark A MA; Beavers. Mary Pat MP; Connolly. Peter J PJ; Middleton. Steve...
Scientists figured out the 3‑D shape of the kisspeptin‑10 peptide and identified three key building blocks that are needed for it to turn on its receptor. Using that info they found small‑molecule chemicals that can also activate the receptor, but these are still experimental and far from any real‑world use.
Jeong. K-H KH; Bakowska. J C JC; Song. I O IO; Fu. N N; Breakefield. X O XO; Kaiser. U B UB
Scientists used a virus to put the natural GnRH gene back into the brains of female mice that couldn't make it on their own. The mice started making the hormone again, their ovaries grew, and some even showed normal menstrual cycles. Giving kisspeptin-10 boosted another hormone (LH), showing the new GnRH system was working properly.
Dittmer. Angela A; Vetter. Martina M; Schunke. Dario D; Span. Paul N PN; Sweep. Fred F; Thomssen. Ch...
Scientists turned off a protein called PTHrP in breast cancer cells and saw many genes change, including ones that control cell division and movement. This also affected the levels of a gene called KISS-1, which makes the peptide kisspeptin. The changes slowed the cells' ability to move and grow, but the study was done in cancer cells in a lab, not in people.
Dhillo. Waljit S WS; Savage. Philip P; Murphy. Kevin G KG; Chaudhri. Owais B OB; Patterson. Michael...
The study shows that the hormone‑like peptide kisspeptin spikes a lot during pregnancy and is also high in a rare placental cancer called gestational trophoblastic neoplasia (GTN), then drops back to almost zero after chemotherapy, matching changes in the pregnancy hormone hCG. This mainly tells doctors that kisspeptin could be used to track this specific cancer, but it doesn’t give everyday health or performance advice for most people.
Mitchell. Dianne C DC; Abdelrahim. Maen M; Weng. Jinsheng J; Stafford. Lewis J LJ; Safe. Stephen S;...
The study shows that a gene called KiSS-1, which can help stop cancer spread, is turned off in aggressive breast cancer cells because two proteins, AP-2α and Sp1, aren’t working together properly. It’s a basic science finding about how cancer cells silence a protective gene, not a guide for using kisspeptin as a supplement or therapy.
Han. Seong-Kyu SK; Gottsch. Michelle L ML; Lee. Kathy J KJ; Popa. Simina M SM; Smith. Jeremy T JT; J...
The study shows that the peptide kisspeptin strongly activates the brain cells that control reproductive hormones in adult mice, but does much less in young mice. This effect is linked to a rise in kisspeptin production at puberty, not to changes in the receptor on those cells. The findings are basic science about puberty timing and don’t give direct guidance for human health hacks.
Niida. Ayumu A; Wang. Zixuan Z; Tomita. Kenji K; Oishi. Shinya S; Tamamura. Hirokazu H; Otaka. Akira...
Scientists created shorter versions of the kisspeptin-10 peptide that still activate its receptor in a yeast test, but there’s no human data or dosing information yet, so it isn’t ready for personal use.
Stathatos. Nikolaos N; Bourdeau. Isabelle I; Espinosa. Allan V AV; Saji. Motoyasu M; Vasko. Vasily V...
The study shows that the peptide kisspeptin‑10 (called metastin) can bind to a receptor (GPR54) on thyroid cancer cells, trigger signaling pathways, and eventually raise levels of a protein (MCIP‑1) that blocks another protein called calcineurin. This chain of events slows down cancer cell growth and movement, suggesting a role in preventing cancer spread, but the work was done in cell cultures, not people.
Masui. Toshihiko T; Doi. Ryuichiro R; Mori. Tomohiko T; Toyoda. Eiji E; Koizumi. Masayuki M; Kami. K...
Researchers found that a natural peptide called metastin (related to kisspeptin-10) can slow down the movement of pancreatic cancer cells in lab dishes, but it doesn't stop the cells from growing. They also made shorter versions of the peptide that worked similarly. This work is still early‑stage and only done in cell cultures, so it doesn’t give any direct instructions for health‑hacking or longevity practices yet.
Ikeguchi. Masahide M; Yamaguchi. Ken-ichi K; Kaibara. Nobuaki N
Researchers looked at two genes, KiSS-1 and its receptor hOT7T175, in esophageal cancer tissue. They found that when these genes are turned off in the tumor, patients are more likely to have cancer spread to lymph nodes. The study suggests these genes could serve as warning signs for aggressive disease, but it doesn’t give any direct advice for health‑boosting or anti‑aging routines.
Ikeguchi. Masahide M; Hirooka. Yasuaki Y; Kaibara. Nobuaki N
This study looked at liver cancer tissue and found that the kisspeptin gene (KiSS‑1) and its receptor (hOT7T175) are often higher in advanced tumors, which may help the cancer grow. It doesn’t give any advice on using kisspeptin‑10 for health or performance.
Harms. John F JF; Welch. Danny R DR; Miele. Mary E ME
The study shows that a protein called KISS1, and a piece of it called kisspeptin, can help stop cancer from spreading, but the exact way it works is still unclear and it’s mainly basic research, not something you can use right now for health hacks.
Takino. Takahisa T; Koshikawa. Naohiko N; Miyamori. Hisashi H; Tanaka. Motohiro M; Sasaki. Takuma T;...
The research shows that the kisspeptin‑10 peptide (called metastin) is quickly cut up by enzymes called matrix metalloproteinases (MMPs), which stops it from working as an anti‑cancer signal. When an MMP blocker is added, the peptide keeps its activity and together they better prevent cancer‑cell movement in lab tests.
Horikoshi. Yasuko Y; Matsumoto. Hirokazu H; Takatsu. Yoshihiro Y; Ohtaki. Tetsuya T; Kitada. Chieko...
Researchers found that the peptide kisspeptin-10, also called metastin, is barely detectable in non‑pregnant people but shoots up thousands‑fold in a woman's blood during pregnancy, coming mainly from the placenta, and then drops back after birth.