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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
George. Jyothis T JT; Millar. Robert P RP; Anderson. Richard A RA
The paper proposes that a hormone called kisspeptin might be the missing link causing low testosterone in overweight men with type‑2 diabetes, but it’s just a hypothesis and doesn’t give any concrete ways to use kisspeptin right now.
Armstrong. R Anne RA; Reynolds. Rebecca M RM; Leask. Rosemary R; Shearing. Catherine H CH; Calder. A...
In early pregnancy, lower levels of the hormone‑like peptide kisspeptin in the mother’s blood are linked to a higher chance of developing pre‑eclampsia or having a baby that grows too slowly, but the differences are small and not enough to use kisspeptin alone as a screening tool.
Qiao. Chong C; Wang. Chunhui C; Zhao. Jiao J; Liu. Caixia C; Shang. Tao T
The study found that the protein made from the KiSS-1 gene (called kisspeptin) is higher in the placentas of women who get early‑onset preeclampsia, but not in later‑onset cases, and it’s also higher in placentas from babies who die in the womb or suffer birth asphyxia. The related receptor GPR54 didn’t change.
Yang. Bo B; Jiang. Quan Q; Chan. Ting T; Ko. Wendy K W WK; Wong. Anderson O L AO
In goldfish, a short form of the hormone kisspeptin (kisspeptin‑10) can directly stimulate the pituitary gland to release more luteinizing hormone, prolactin, and growth hormone, and also boost the genes that make these hormones. This effect happens without needing the brain’s usual signaling pathways.
McNally. Lacey R LR; Welch. Danny R DR; Beck. Benjamin H BH; Stafford. Lewis J LJ; Long. Joshua W JW...
In a mouse study, forcing pancreatic cancer cells to make more of the protein KISS1 dramatically cut the spread of tumors to the liver and lungs, but only when the protein could be secreted. The work used gene‑transfer techniques, not a simple peptide supplement, and was done in animals, not people, so it doesn’t give a usable protocol for self‑experimenters yet.
Kauffman. A S AS
This study shows that the brain cells that make the hormone kisspeptin are different in males and females, especially in areas that control puberty and fertility. In females, there are more kisspeptin cells in a region called the AVPV/PeN, and this is driven by estrogen during early life. In another region, the ARC, the number of cells is similar in adults, but early development is influenced by sex‑specific factors that don’t depend on hormones.
Chan. Yee-Ming YM; Fenoglio-Simeone. Kristina A KA; Paraschos. Sophia S; Muhammad. Laura L; Troester...
This study looked at brain growths called hypothalamic hamartomas that sometimes cause kids to go through puberty early. It found that the ones linked to early puberty are bigger and touch specific brain areas, while the levels of the kisspeptin gene (KISS1) and related proteins are the same whether puberty is early or not. So, the shape and size of the growth matter more than the kisspeptin signals.
Lee. Kyung Hee KH; Kim. Jae-Ryong JR
The study shows that the protein Kiss-1 can lower a cancer‑related enzyme (MMP‑9) by turning on a cell signaling pathway (p38 MAPK) in stomach cancer cells, but it’s all done in petri‑dish experiments and doesn’t give any dosing or safety info for people.
Whitlock. B K BK; Daniel. J A JA; Wilborn. R R RR; Maxwell. H S HS; Steele. B P BP; Sartin. J L JL
In simple terms, giving kisspeptin to cows or sheep through the bloodstream boosts the reproductive hormone LH but doesn’t raise growth hormone (GH). However, when kisspeptin is delivered directly into the brain of sheep, it does increase GH. The study shows kisspeptin can affect both reproductive and growth pathways, but only when it reaches the brain, not when taken peripherally.
Chen. Ying Y; Yusenko. Maria V MV; Kovacs. Gyula G
Researchers found that kidney cancer tumors that don’t have the KISS1R protein tend to grow and spread faster. In lab tests, giving the peptide kisspeptin slowed down cancer cell movement and made the cells produce more KISS1R. This suggests KISS1R could help predict how aggressive a tumor will be and that kisspeptin might one day be used as a treatment, but it’s still early-stage research.
Desroziers. E E; Mikkelsen. J J; Simonneaux. V V; Keller. M M; Tillet. Y Y; Caraty. A A; Franceschin...
Scientists looked at where kisspeptin, a hormone that controls reproduction, is found in the brains of female rats. They used two different antibodies and saw that most kisspeptin fibers are in specific brain areas, but one antibody (anti‑Kp‑10) also picked up extra spots, suggesting it may detect more forms of the peptide.
Silveira. Leticia Gontijo LG; Tusset. Cintia C; Latronico. Ana Claudia AC
Mutations that mess up kisspeptin or neurokinin B signaling can cause serious reproductive issues like low hormone levels, tiny penis, undescended testes, or even early puberty. Kisspeptin is a strong trigger for the hormone GnRH that starts the reproductive cascade, while neurokinin B’s exact role is still fuzzy. People with these mutations can sometimes be helped with hormone therapies like gonadotropins or pulsatile GnRH.
Peng. Jing J; Xu. Hong H; Yang. Bei B; Hu. Jia J; Zhang. Bao-Ping BP; Zou. Lin L; Kuang. Hai-Bin HB
The study found that blood levels of the peptide kisspeptin are not meaningfully higher in postmenopausal Chinese women compared to younger women, and they don’t track with the hormone changes that happen after menopause. This means kisspeptin isn’t a useful blood test for spotting menopause or guiding hormone‑related tweaks.
Ko. Jung Min JM; Lee. Hyo Sung HS; Hwang. Jin Soon JS
Researchers looked at a gene called KISS1 in Korean girls and found a rare variant (p.P110T) that appears less often in those who start puberty early, suggesting it might protect against early puberty. However, the study doesn’t give any tips on how to use this information for health or performance in adults.
Lehman. Michael N MN; Coolen. Lique M LM; Goodman. Robert L RL
The paper explains that a group of brain cells in the hypothalamus called KNDy cells release three chemicals—including kisspeptin—that help control the release of reproductive hormones. These cells act like a hub, receiving hormone signals and sending pulses to trigger hormone release, and problems with them may be linked to conditions like PCOS.
Curtis. Annette E AE; Murphy. Kevin G KG; Chaudhri. Owais B OB; Ramachandran. Radha R; Young. Anna-M...
Researchers found that prostate cancer cells can release a molecule called kisspeptin in the lab, and the gene for kisspeptin is present in normal prostate tissue, but people with prostate cancer don’t have higher kisspeptin levels in their blood, so it isn’t a useful blood test or supplement right now.
Smith. Jeremy T JT; Saleh. Sofie N H SN; Clarke. Iain J IJ
In sheep, giving the peptide kisspeptin-10 makes the hormone LH go up, especially when the animals are not in their breeding season or during the late follicle phase. The effect is similar to giving GnRH and doesn't change other hormones like growth hormone or cortisol.
Whitlock. Brian K BK; Daniel. Joseph A JA; Wilborn. Robyn R RR; Rodning. Soren P SP; Maxwell. Herris...
In cows without ovaries, the peptide kisspeptin‑10 can boost the hormone that triggers ovulation (LH), but it only raises growth hormone (GH) when the animals are also given estrogen or progesterone. This means sex hormones make the body more responsive to kisspeptin’s effect on growth hormone.
Pentheroudakis. G G; Kostadima. L L; Dova. L L; Georgiou. I I; Tzavaras. T T; Vartholomatos. G G; Wi...
The study looked at a gene called KiSS1, which makes a protein that can stop cancer from spreading. In early‑stage breast cancer, a small number of tumors had a genetic change that altered the protein and lowered its levels, but this didn’t clearly affect how the disease progressed or patients’ survival.
Beck. Benjamin H BH; Welch. Danny R DR
KISS1 is a protein that can stop cancer cells from forming new tumors after they spread. When tumors lose KISS1, they tend to grow and spread faster. Scientists think boosting KISS1 could be a way to treat metastasis, but no practical treatment or dosage is available yet.