González-Martínez. David D; De Mees. Christelle C; Douhard. Quentin Q; Szpirer. Claude C;...
In mice that can’t make a protein called AFP, prenatal estrogen exposure messes up the brain cells that normally trigger ovulation, so female mice lose the usual hormone surge that leads to egg release. This also dampens the activity of kisspeptin‑10 neurons, which normally help start that surge. The findings show that early hormone exposure can permanently change the reproductive hormone system.
Ansel. L L; Bolborea. M M; Bentsen. A H AH; Klosen. P P; Mikkelsen. J D JD; Simonneaux. V V
The study shows that in Syrian hamsters, the hormone melatonin and sex steroids control the brain's kisspeptin (Kiss1) levels differently depending on the season and brain region. Short days (like winter) lower kisspeptin, while giving sex hormones can raise it in one brain area (AVPV) but lower it in another (ARC). Melatonin directly suppresses kisspeptin in the ARC, and indirectly in the AVPV by reducing sex hormones.
de Vries. L L; Shtaif. B B; Phillip. M M; Gat-Yablonski. G G
Researchers measured kisspeptin levels in girls with early puberty and found they were higher than in normal pre‑pubertal girls, but the numbers overlapped a lot, so kisspeptin alone can't reliably tell if a girl has true central precocious puberty.
Cheng. Guanliang G; Coolen. Lique M LM; Padmanabhan. Vasantha V; Goodman. Robert L RL; Lehman. Micha...
In sheep, a group of brain cells that make kisspeptin, neurokinin B, and dynorphin (called KNDy cells) are fewer in males than females. Giving female sheep testosterone before they are born cuts down the number of some of these cells, but not the kisspeptin ones. This shows that different hormones affect each peptide at different times during development.
Constantin. Stephanie S; Caraty. Alain A; Wray. Susan S; Duittoz. Anne H AH
Researchers studied how a hormone called GnRH is released from mouse tissue grown in a dish and found that the release starts early, gets stronger as the cells mature, and can be boosted by a molecule called kisspeptin-10, which lines up with calcium signals in the cells.
Navenot. Jean-Marc JM; Fujii. Nobutaka N; Peiper. Stephen C SC
Kisspeptin-10 activates a receptor called GPR54, which blocks growth signals from epidermal growth factor and insulin receptors and triggers cell death mainly through an ERK‑driven inflammation pathway. This could help stop cancer cells from spreading, but the work was done in lab cell lines and gives no human dosing or safety guidance.
Lee. Yeo Reum YR; Tsunekawa. Kenta K; Moon. Mi Jin MJ; Um. Haet Nim HN; Hwang. Jong-Ik JI; Osugi. To...
Scientists mapped how kisspeptin proteins and their GPR54 receptors have changed across animals like fish and frogs, finding several different versions that work differently in the brain. This helps us understand the basic biology but doesn’t give any direct tips for using kisspeptin in humans.
Karapanagiotou. Eleni M EM; Dilana. Kalliopi D KD; Gkiozos. Ioannis I; Gratsias. Ioannis I; Tsimpouk...
The study measured blood levels of the peptide kisspeptin-10 (called metastin) in lung cancer patients and healthy people and found no differences. It also showed that metastin levels don't tell you whether the cancer has spread or relate to leptin levels. In short, metastin isn’t useful as a diagnostic or prognostic marker for non‑small cell lung cancer.
During breastfeeding, the body ramps up hunger signals and cuts down on the hormone kisspeptin in the brain, which together shut off the pulse of GnRH (the hormone that drives fertility). This suppression seems to be driven mainly by reduced kisspeptin, while low leptin and insulin mainly fuel the increased appetite needed for milk production.
In a lab study using breast cancer cells, researchers found that the hormone estrogen (E2) quickly reduces the amount of the kisspeptin gene (KISS1) by pulling away the machinery that makes RNA from the gene's start site. This happens even when the estrogen receptor can't stick to DNA, showing a non‑traditional way estrogen shuts down KISS1.
Mitra. Aparna A; Fillmore. Rebecca A RA; Metge. Brandon J BJ; Rajesh. Mathur M; Xi. Yaguang Y; King....
Scientists found that a larger version of a protein called MRJ (DNAJB6) is missing in aggressive breast cancers. When they added this protein back into cancer cells, the cells became less invasive, grew slower, and released more of a natural cancer‑blocking molecule called KiSS1, while releasing less of proteins that help tumors spread. This shows the protein may help keep breast cancer from growing and spreading, but it doesn’t give a clear way for everyday people to use kisspeptin‑10 for health benefits.
Smets. Eva M L EM; Deurloo. Koen L KL; Go. Attie T J I AT; van Vugt. John M G JM; Blankenstein. Mari...
Researchers found that pregnant women who later have babies that are smaller than expected have lower levels of a hormone called metastin (kisspeptin‑10) in their blood during the first trimester, while another hormone, beta‑hCG, stays the same.
This paper reviews how the kisspeptin system helps create sex‑specific brain wiring and hormone responses, especially the estrogen‑driven LH surge in females and certain brain and spinal traits in males. It shows that differences in kisspeptin levels are set during early development, not by adult dosing, and that the system is tied to broader sex‑specific behaviors.
Nakamura. Yasuhiro Y; Aoki. Satoshi S; Xing. Yewei Y; Sasano. Hironobu H; Rainey. William E WE
The study shows that the peptide kisspeptin (metastin) can double aldosterone production in human adrenal cells in lab experiments, especially at higher concentrations, but this was only observed in cell cultures and fetal tissue, not in real people.
A short piece of the KiSS-1 protein (called metastin 45‑54) was tested on kidney cancer cells in a dish and was found to make the cells less able to invade and move, mainly by lowering a molecule called MMP‑2 that helps cells break through tissue. This effect only showed up in cells that didn’t already make KiSS‑1 themselves.
This paper reviews how the KiSS1 gene, which makes kisspeptin proteins, is controlled in the body. Kisspeptin helps start puberty and can stop cancer spread, but we still don’t fully know what turns the gene on or off.
Moon. Jung Sun JS; Lee. Yeo Reum YR; Oh. Da Young DY; Hwang. Jong Ik JI; Lee. Ju Yeon JY; Kim. Jae I...
Scientists copied the kisspeptin receptor gene from a bullfrog and showed it works like the human version, reacting to human kisspeptin‑10 and a frog peptide. The receptor is mostly found in brain areas that control hormones, and it signals through a PKC pathway. This tells us the kisspein system is evolutionarily conserved, but it doesn’t give new tips for human health hacks.
Zhang. Chunguang C; Roepke. Troy A TA; Kelly. Martin J MJ; Rønnekleiv. Oline K OK
Kisspeptin makes the brain cells that control reproductive hormones fire more by opening special ion channels (TRPC) and partly blocking potassium channels, leading to a strong electrical activation of those cells.
Teles. Milena Gurgel MG; Bianco. Suzy D C SD; Brito. Vinicius Nahime VN; Trarbach. Ericka B EB; Kuoh...
Scientists found a genetic change (Arg386Pro) in the GPR54 receptor that makes it stay active longer when kisspeptin binds, and this over‑activity is linked to a girl developing puberty far earlier than normal.
Researchers found that kidney cancer cells have a lot of the receptor for a peptide called metastin, and when they added metastin in the lab it stopped the cancer cells from moving and invading, but it didn’t slow their growth. This effect involved changes in cell structures that were blocked by a Rho‑kinase inhibitor.