The study shows that the hormone‑like peptide kisspeptin and its receptor appear in the fetal brain early in pregnancy and increase until about week 30, while the fetal blood levels of LH and FSH drop. After week 30, the release of LH and FSH becomes dependent on kisspeptin signaling. This reveals how the fetal reproductive hormone system is wired, but it doesn’t give any direct tips for adult health or performance.
Moya. Patricia P; Esteban. Sergio S; Fernandez-Suarez. Antonio A; Maestro. Marisa M; Morente. Manuel...
Researchers found that a gene called KiSS-1, which normally helps stop cancer spread, is often turned off in colon cancer because its DNA gets extra chemical tags (methylation). This silencing shows up in tissue samples and is linked to worse tumor grades, higher chances of recurrence, and lower survival rates. While the findings improve how doctors might diagnose or predict colon cancer outcomes, they don’t give direct advice on using kisspeptin‑10 for health or performance purposes.
Ulasov. Ilya V IV; Kaverina. Natalya V NV; Pytel. Peter P; Thaci. Bart B; Liu. Feifei F; Hurst. Doug...
The study found that the protein KISS1, which can help stop cancer spread, is present more in early‑stage breast tumors than in tumors that have moved to the brain, and lower levels are linked to worse outcomes.
The study found that people with colorectal cancer have higher levels of a protein called kisspeptin-54 in their blood compared to healthy people, and that higher levels are linked to cancer spreading to lymph nodes. However, this is just a diagnostic marker, not something you can take or change with lifestyle or supplements.
Li. Na N; Wang. Hong-Xing HX; Zhang. Jie J; Ye. Ya-Ping YP; He. Guo-Yang GY
Scientists put extra copies of the KISS-1 gene into stomach cancer cells and found the cells grew slower, were less able to invade, and formed smaller tumors in mice, likely because they made less of a protein called MMP‑9 that helps cancer spread.
Researchers found that the gene for kisspeptin (KISS1) is often turned off in colon cancer because its DNA gets a chemical tag called methylation. When they used a drug that removes these tags, the gene turned back on and cancer cells moved less, hinting that the gene helps keep tumors from spreading.
Huijbregts. Lukas L; Roze. Catherine C; Bonafe. Giulia G; Houang. Muriel M; Le Bouc. Yves Y; Carel....
Scientists found that tiny DNA changes near the KISS1 gene can alter the shape of a special DNA structure called a G‑quadruplex, which in turn changes how much of the kisspeptin protein is made. This may affect when puberty starts, but it doesn’t tell us how to use kisspeptin‑10 as a supplement or therapy.
Adali. Ertan E; Kurdoglu. Zehra Z; Kurdoglu. Mertihan M; Kamaci. Mansur M; Kolusari. Ali A; Yildizha...
The study found that pregnant women with pre‑eclampsia have lower blood levels of the peptide kisspeptin‑10 (called metastin) compared to healthy pregnancies, and the lower the level, the more severe the disease appears to be.
The study looked at lung cancer patients and found that higher levels of certain markers, including the protein Kiss-1, were linked to how long patients survived, but Kiss-1 itself wasn’t a strong independent predictor of outcome.
Porzionato. A A; Fenu. G G; Rucinski. M M; Macchi. V V; Montella. A A; Malendowicz. L K LK; De Caro....
Researchers found that the hormone kisspeptin and its receptor are present in the oxygen‑sensing cells of the carotid body and in sympathetic nerve cells, as well as in blood‑vessel lining cells, in both humans and rats. This suggests kisspeptin could influence how the body senses oxygen and controls blood flow, but the study doesn’t test any treatments or dosages.
Francis. Víctor A VA; Abera. Aron B AB; Matjila. Mushi M; Millar. Robert P RP; Katz. Arieh A AA
The study shows that kisspeptin‑10 can slow down the movement and blood‑vessel‑forming ability of early‑pregnancy placental cells by turning off genes that help cells break through tissue. This effect is seen in lab‑grown human cells and involves the kisspeptin receptor and a signaling pathway called ERK1/2.
Ezzat Ahmed. Ahmed A; Saito. Hayato H; Sawada. Tatsuru T; Yaegashi. Tomoyoshi T; Jin. Jin J; Sawai....
In simple terms, the study found that a short piece of the hormone kisspeptin (kisspeptin‑10) can make cow pituitary cells release growth hormone, but adding estrogen, progesterone, or testosterone doesn’t make this effect stronger. However, kisspeptin‑10 is much weaker at triggering growth hormone than the usual hormone‑releasing factor (GHRH). The work was done in isolated bovine cells, not in people.
Cartwright. Judith E JE; Williams. Paula Juliet PJ
The study looked at a protein called kisspeptin and its receptor in the placenta and found that in women with pre‑eclampsia, kisspeptin levels are lower while its receptor levels are higher, which may affect how the placenta develops.
This review explains that the start of puberty is controlled by a mix of genes, hormones, and environmental factors, with no single cause. It highlights that genetics and the environment both influence the brain’s release of hormones that trigger puberty, and that new genetic tools might help us understand these processes better.
Gürbüz. Fatih F; Kotan. L Damla LD; Mengen. Eda E; Şıklar. Zeynep Z; Berbero&#...
This study looked at families where several members have a rare condition that stops puberty because the brain doesn’t release the right hormones. They found that about three‑quarters of these families have mutations in five specific genes, with two genes (GNRHR and TACR3) being the most common. Mutations in the kisspeptin gene (KISS1) and its receptor (KISS1R) were also seen, showing they play a role in starting puberty.
Researchers checked a specific genetic variation (Q36R) in the kisspeptin gene among Brazilian head‑and‑neck cancer patients and healthy people. Overall, the variation wasn’t more common in cancer patients, but it showed up a bit more in those with pharyngeal cancer. The study doesn’t give any direct tips for using kisspeptin supplements or protocols for health or performance.
Arab. Khelifa K; Smith. Laura T LT; Gast. Andreas A; Weichenhan. Dieter D; Huang. Joseph Po-Hsien JP...
In aggressive skin cancer, a gene called TCF21 gets turned off by a chemical tag (DNA methylation). When TCF21 is off, it can’t boost another gene, KISS1, which makes a peptide (kisspeptin) that helps stop cancer spread. Turning TCF21 back on brings KISS1 levels up and makes the cancer cells move less.
The study found that a small protein piece called kisspeptin-10 (also known as metastin-10) can help stop endometrial cancer cells from spreading, but only when the cancer cells have enough of its partner receptor, GPR54. Higher levels of GPR54 were linked to better survival, and drugs that turn on GPR54 might make kisspeptin-10 work better.
The study found that the protein KISS1, which can act like a brake on cancer spread, is present in high amounts in normal prostate tissue but drops in prostate cancers, especially the aggressive ones. Adding back the full KISS1 protein to prostate cancer cells made them more likely to die when detached (a process called anoikis) and less able to move and invade, and it even made them more sensitive to a chemotherapy drug. However, the research was done in lab cells, not in people, and it didn’t test any practical way to use kisspeptin‑10 as a supplement or therapy.
Ramaesh. Thayalini T; Logie. James J JJ; Roseweir. Antonia K AK; Millar. Robert P RP; Walker. Brian...
Kisspein‑10, a short form of the hormone kisspeptin, was shown to block the growth of new blood vessels in human placental tissue and in cultured endothelial cells, without killing the cells but slowing their growth and movement. This effect was seen in lab experiments and depends on the amount used.