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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Tena-Sempere. Manuel M
The paper reviews how the brain hormone kisspeptin and related signals control when puberty starts, showing that metabolism, epigenetics, and tiny RNA molecules also play roles, but it doesn’t give any new tricks or dosing advice for adults.
Yilmaz. S A SA; Kerimoglu. O S OS; Pekin. A T AT; Incesu. F F; Dogan. N U NU; Celik. C C; Unlu. A A
The study found that women with polycystic ovary syndrome (PCOS) have higher blood levels of metastin (kisspeptin-10) than women without PCOS, and these higher levels are linked to higher androgen hormones and hirsutism scores, regardless of body weight.
Sukhbaatar. Unurjargal U; Kanasaki. Haruhiko H; Mijiddorj. Tselmeg T; Oride. Aki A; Miyazaki. Kohji...
This study looked at how two hormones, GnRH and kisspeptin, affect the levels of receptors for another hormone (GnIH) in mouse pituitary and brain cells. It found that GnRH can boost these receptors, especially when given in slow, spaced‑out pulses, and that occasional kisspeptin exposure also raises receptor levels in brain cells. The work is done in cell cultures, not people, so it doesn’t give direct advice for health or performance.
Roseweir. A K AK; Katz. A A AA; Millar. R P RP
Researchers found that a short piece of the hormone kisspein, called kisspeptin‑10, can stop certain placental cells from moving in a dish by turning on a chain of signals inside the cells. This effect happens at a concentration of about 100 nM and involves blocking a protein called GSK3β and changing how other proteins that control cell adhesion behave.
Skrapits. Katalin K; Borsay. Beáta Á BÁ; Herczeg. László L; Ciofi. Philippe...
Researchers looked at human brain tissue and found that a peptide called CART is present in some kisspeptin and neurokinin B neurons, which are involved in hormone regulation. This pattern is different from what is seen in rodents, and the exact role of CART in these neurons is still unknown.
Albers-Wolthers. Karin H J KH; de Gier. Jeffrey J; Kooistra. Hans S HS; Rutten. Victor P M G VP; van...
Researchers found that a short form of the kisspeptin hormone (KP-10) works very well in female dogs that are not in heat, quickly raising reproductive hormones like LH, FSH, and estradiol at very low doses.
Ni. Yingdong Y; Huang. Yanbing Y; Xiao. Yunqi Y; Wu. Jing J; Qian. Fuyu F; Grossmann. Roland R; Zhao...
Giving young female quail daily injections of the peptide kisspeptin‑10 made them start laying eggs sooner, with faster ovarian growth and higher estrogen. The hormone signals in the brain and pituitary changed in ways that normally drive reproduction.
Martínez-Fuentes. Antonio J AJ; Molina. Marcelo M; Vázquez-Martínez. Rafael R; Gahete...
The study found that the hormone‑like peptide kisspeptin‑10 can trigger cell‑death signals in pituitary tumor cells, especially those that make growth hormone, but it doesn’t show any clear benefit or safe way to use it for healthy people looking to improve longevity or performance.
Kavvasoglu. Serif S; Ozkan. Zehra Sema ZS; Kumbak. Banu B; Sımsek. Mehmet M; Ilhan. Necip N
The study found that pregnant women who experienced early bleeding had lower levels of the hormone kisspeptin‑10 compared to those without bleeding, and lower kisspeptin‑10 was linked to later pregnancy complications, but the research is very small and doesn’t show how to use this information outside of a clinical setting.
Zajac. Mateusz M; Law. Jeffrey J; Cvetkovic. Dragana Donna DD; Pampillo. Macarena M; McColl. Lindsay...
Kisspeptin‑10, a short peptide that normally helps regulate hormones, was found to make breast cancer cells more invasive by turning on the EGFR pathway and increasing an enzyme that breaks down tissue.
Krstevska-Konstantinova. Marina M; Jovanovska. Jana J; Tasic. Velibor B VB; Montenegro. Luciana Ribe...
Researchers looked at the genes that make kisspeptin and its receptor in 28 girls who started puberty very early. They didn’t find any rare mutations, meaning these gene changes aren’t a common reason for early puberty.
Kurian. Joseph R JR; Keen. Kim L KL; Guerriero. Kathryn A KA; Terasawa. Ei E
The study shows that blocking GABA signals in young monkeys sharply raises kisspeptin release, which then boosts GnRH hormone and may trigger puberty. This effect disappears once the monkeys reach puberty, and stopping kisspeptin stops the GnRH boost, suggesting kisspeptin acts as a bridge between GABA and GnRH. The findings are about puberty timing in monkeys, not directly about adult health or performance.
Porteous. Robert R; Petersen. Sandra L SL; Yeo. Shel Hwa SH; Bhattarai. Janardhan P JP; Ciofi. Phili...
Scientists discovered that brain cells in female mice that make the hormone‑related peptide kisspeptin also produce other small proteins called galanin and met‑enkephalin, which could change how these cells control reproductive hormones. This is a basic science finding and doesn’t give any direct advice on using kisspeptin for health or performance.
Zhang. Y Y; Tang. Y J YJ; Li. Z H ZH; Pan. F F; Huang. K K; Xu. G H GH
The study found that the protein KiSS1, which comes from the kisspeptin peptide, is reduced in bone cancer tissue and that boosting its levels in cancer cells slows their growth and spread by turning down a signaling pathway called MAPK.
Cho. Sung-Gook SG; Wang. Ying Y; Rodriguez. Melissa M; Tan. Kunrong K; Zhang. Wenzheng W; Luo. Jian...
In mouse experiments, having only one working copy of the kisspeptin receptor (KISS1R) slowed down breast cancer start, growth, and spread to the lungs. Adding the peptide kisspeptin‑10 turned the receptor on, which then activated a RhoA signaling chain that helped cancer cells grow and form colonies. Knocking down the receptor or blocking RhoA reduced these cancer‑promoting effects.
Kanda. Shinji S; Oka. Yoshitaka Y
The paper explains that kisspeptin, a peptide important for reproduction, comes in two forms (Kiss1 and Kiss2) and can bind to two related receptors in some animals. It mainly looks at how these genes evolved across species, rather than testing any health‑boosting effects in people.
Park. Dong-Wook DW; Lee. Sung-Ki SK; Hong. Sung Ran SR; Han. Ae-Ra AR; Kwak-Kim. Joanne J; Yang. Kwa...
The study found that women who have had repeated miscarriages show lower levels of the hormone kisspeptin in the cells that form the placenta, and this drop is linked to higher numbers of certain immune cells (NK cells) in the uterus. The kisspeptin receptor didn’t change, and more NK cells were seen when blood NK cells were high, which correlated with the lower kisspeptin levels.
Tan. K K; Cho. S-G SG; Luo. W W; Yi. T T; Wu. X X; Siwko. S S; Liu. M M; Yuan. W W
In lab experiments, the peptide kisspeptin-10 was shown to slow down the movement and spread of breast cancer cells by turning on a protein called PKD1, which then blocks changes that make cancer cells more aggressive. This effect was seen in cell cultures, not in people.
Chan. Yee-Ming YM; Broder-Fingert. Sarabeth S; Paraschos. Sophia S; Lapatto. Risto R; Au. Margaret M...
Scientists found rare changes in the KISS1 gene that can lower hormone signals needed for reproduction, and mice with similar gene changes have lower testosterone and reproductive problems. These findings mainly explain why some people have reproductive issues, but they don’t give a clear way to use kisspeptin‑10 for health or performance improvements.
Teng. Y Y; Mei. Y Y; Hawthorn. L L; Cowell. J K JK
The study shows that a protein called WASF3 can make breast cancer cells more invasive by lowering the levels of another protein, kisspeptin (KISS1), which normally helps keep cells from spreading. When WASF3 is high, it boosts ZEB1/2, which shuts down a micro‑RNA cluster that protects against invasion, leading to more aggressive cancer behavior. Reducing WASF3 levels reverses these effects and makes the cells less invasive.