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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Dun. Siok L SL; Brailoiu. G Cristina GC; Parsons. Amy A; Yang. Jun J; Zeng. Qiang Q; Chen. Xiangqun...
This study found that the peptide kisspeptin (also called metastin) is naturally present in certain parts of the rat brainstem and spinal cord that control automatic body functions and sensory signals. It doesn’t test any treatments or give dosage advice, so it’s mainly basic science.
Navarro. Victor M VM; Castellano. Juan M JM; García-Galiano. David D; Tena-Sempere. Manuel M
The paper explains that a brain chemical called kisspeptin is a key switch that starts puberty by turning on the reproductive hormone system. Experiments in mice and humans show that if the kisspeptin pathway doesn’t work, puberty doesn’t happen. The authors also note that metabolism and possibly the environment can affect this system, but they don’t give any practical ways to use kisspeptin for health or performance.
Janneau. Jean-Louis JL; Maldonado-Estrada. Juan J; Tachdjian. Gérard G; Miran. Isabelle I; Mott...
The study looks at how the kisspeptin gene (KiSS‑1) and its receptor are turned on in cells that help form the placenta, comparing early and late pregnancy and some disease models. It finds that kisspeptin is more active early in pregnancy and less so in cancer‑like cells, suggesting it helps control how these cells move and invade tissue.
Schmid. Katharina K; Wang. Xiaowei X; Haitel. Andrea A; Sieghart. Wolfang W; Peck-Radosavljevic. Mar...
A study looked at the protein kisspeptin-10 (produced by the KiSS-1 gene) in liver cancer tissue and found that higher levels of this protein were linked to worse survival, making it a potential marker for aggressive tumors.
Hori. A A; Honda. S S; Asada. M M; Ohtaki. T T; Oda. K K; Watanabe. T T; Shintani. Y Y; Yamada. T T;...
The study shows that a short piece of the kisspeptin protein, called metastin, can stop certain hamster cells from moving and growing in lab dishes, but it was only tested in cell cultures, not in people.
Becker. Jérôme A J JA; Mirjolet. Jean-François JF; Bernard. Jérôme J; Burge...
The study shows that the peptide kisspeptin-10, when it binds to its receptor GPR54 on certain cancer cells, triggers a unique set of genes that stop the cells from dividing and cause them to die. This effect is different from what happens when a similar receptor (the bradykinin B2 receptor) is activated, even though both use the same type of internal signaling protein.
Yan. C C; Wang. H H; Boyd. D D DD
The study shows that the peptide kisspeptin (KiSS‑1) can lower the production of an enzyme called MMP‑9, which helps break down tissue, by blocking a specific gene‑switching protein (NF‑kB). This effect was seen in cancer cells grown in the lab and does not translate into any clear health‑boosting advice for everyday use.
Martin. Tracey A TA; Watkins. Gareth G; Jiang. Wen G WG
The study found that higher levels of the peptide kisspeptin-10 (produced from the KiSS-1 gene) are linked to more aggressive breast cancers and worse patient outcomes, and that adding KiSS-1 to breast cancer cells makes them move and invade more.
Song. W-W WW; Gui. A-P AP; Li. W W; Chen. H-S HS; Li. J-M JM
The study looked at two proteins, HIF‑1α and KISS‑1, in liver cancer tissue compared to normal liver tissue. It found that HIF‑1α was much higher and KISS‑1 was much lower in the cancer samples, and these differences were statistically significant. The authors suggest these proteins could help gauge how bad liver cancer is, but they didn’t test any treatments or give advice on using kisspeptin‑10.
Arjmand. Mohammad M; Mirzaei. Abdolah A; Jafarzadeh Shirazi. Mohammad Reza MR; Tamadon. Amin A; Sale...
In a study on a specific breed of goats, researchers found that a single low dose of kisspeptin-10 did not boost the hormone LH that triggers ovulation when the animals were not cycling, and that seasonal factors plus male presence affected whether the goats showed signs of a luteal phase.
Matthaiou. Spyridon S; Kostakis. Ioannis D ID; Kykalos. Stylianos S; Machairas. Nikolaos N; Spartali...
The study looked at the levels of kisspeptin (KISS1) and its receptor (KISS1R) in colon cancer tissue and found that higher levels show up in more advanced tumors, and surprisingly, people with more KISS1R lived longer. However, the research only measured these proteins in tumor samples and didn’t test any treatments or supplements, so there’s nothing you can directly apply right now.
Dong. Hui-Ming HM; Huang. Jian-Kang JK; Gong. Xiao-Meng XM; Tao. Yi-Sheng YS
The study measured three proteins—MACC1, Snail and KISS‑1—in breast cancer tissue and normal breast tissue. It found that cancer tissue had higher MACC1 and Snail (both linked to worse outcomes) and lower KISS‑1 (a protein that seems to protect against cancer). Patients whose tumors kept KISS‑1 levels high lived longer, while those with high MACC1 or Snail lived shorter lives.
Chen. Shaoqin S; Su. Xiaobao X; Gao. Ji J; Han. Hongjing H; Chen. Zhihua Z; Lin. Suyong S
Scientists put extra copies of the kisspeptin gene (Kiss-1) into colon cancer cells in a dish and found the cells grew and spread less, likely because the gene turned down a pathway (NF‑κB) that helps tumors move.
Tan. Jingyu J; Zhang. Guoqing G; Liu. Rui R; Zhou. Mi M; Li. Zhongtang Z; Wu. Zhongjun Z
Scientists forced liver cancer cells to make more of a protein called TCF21 and saw that the cells grew slower, moved less, and died more. This was linked to higher levels of a molecule named KISS1 (related to the kisspeptin peptide) and the tumor‑suppressor p53, while a protein that helps tumors spread, MMP‑9, went down.
Hesling. C C; D'Incan. M M; Mansard. S S; Franck. F F; Corbin-Duval. A A; Chèvenet. C C; Dé...
A single patient with skin melanoma metastases was treated with a cream called imiquimod for eight weeks. After treatment, the skin lesion showed higher levels of a gene called KiSS-1 (which makes the peptide kisspeptin) and some other proteins that can block tumor spread, while a protein that helps tumors grow new blood vessels (MMP‑9) dropped a lot. The study only looked at gene activity, not actual tumor shrinkage, and it’s just one case.
Chen. Shao-qin SQ; Tu. Ming-mei MM; Dai. Qi-bao QB; Lin. Su-yong SY; Ke. Chun-lin CL
The study looked at how exposing colon cancer cells to X‑ray radiation changes the levels of a protein called Kiss‑1, which can suppress tumor spread. Higher radiation doses (6‑8 Gy) raised the amount of Kiss‑1 protein and made the cancer cells grow slower and die more, while lower doses had mixed effects on the gene’s messenger RNA. This is a lab‑only finding and doesn’t give a clear way for people to use kisspeptin‑10 in everyday health or longevity routines.
Zhou. Lei L; Hu. Yong-Lian YL; Wu. Shi-Wu SW; Yu. Lan L; Cheng. Ze-Nong ZN; Zhu. Bo B
Researchers examined three proteins—Slug, ZEB1 and KISS‑1—in stomach cancer and normal stomach tissue, finding that cancer tissue has high Slug and ZEB1 but low KISS‑1, while normal tissue shows the opposite. High Slug or ZEB1 and low KISS‑1 were linked to deeper tumors, more lymph‑node spread, higher cancer stage, and shorter patient survival.
Nazir. M M; Kayani. M R MR; Malik. Faraz Arshad FA; Masood. Nosheen N; Kayani. Mahmood Akhtar MA
The study looked at two genes, KISS1 (which makes the peptide kisspeptin) and KAI1, in 120 Pakistani head and neck cancer patients and found no inherited (germ‑line) mutations in the parts of the genes that code for proteins. Only two tiny DNA changes in non‑coding regions of KAI1 were seen in 1% of patients, so the usual drop in these genes in cancer isn’t due to inherited mutations.
Papaoiconomou. Eleni E; Lymperi. Maria M; Petraki. Constantina C; Philippou. Anastassios A; Msaouel....
The study found that the proteins Kiss‑1 and its receptor GPR54 are present at higher levels in breast cancer tissue compared to non‑cancerous breast tissue, but these levels don’t predict how aggressive the tumor is.
Zheng. Suqin S; Chang. Yanhe Y; Hodges. Kurt B KB; Sun. Ying Y; Ma. Xiaobing X; Xue. Yi Y; Williamso...
The study looked at two proteins, KISS1 (which includes the peptide kisspeptin‑10) and MMP‑9, in lung cancer patients. Higher levels of KISS1 were found in early‑stage tumors and were linked to better 5‑year survival, while higher MMP‑9 was seen in later stages and linked to worse outcomes. The two proteins tended to go in opposite directions.