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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Messager. Sophie S
Scientists discovered that the hormone kisspein-10 (kisspeptin) is a key trigger for starting puberty. If the kisspeptin receptor is broken, both humans and mice can't go through puberty and become sterile. This finding points to new ways to treat puberty timing problems, infertility, and hormone‑linked cancers, but it doesn't give any direct DIY tips.
Li. Na N; Li. Shan-shan SS; Zhang. Hong-yan HY; Xuan. Xiao-yan XY; Zheng. Xian-zhao XZ; Wang. Feng F...
Scientists put more of the kisspeptin‑10 gene (KISS‑1) into esophageal cancer cells and saw those cells become less able to invade and grow, showing KISS‑1 acts like a brake on tumor behavior in the lab.
Liang. Qi-Lian QL; Chen. Xiao-Dong XD; Wang. San-Ming SM; Li. Jian-Wen JW; Huang. Bing B; Xu. Yan-Yu...
The study looked at two proteins, VEGF and metastin (kisspeptin), in colon cancer tissue versus nearby normal tissue. VEGF was higher in tumors, while metastin was lower, and both levels were linked to how aggressive the cancer was.
Crowley. William F WF; Pitteloud. Nelly N; Seminara. Stephanie S
This paper reviews how studying rare genetic disorders that affect the hormone that controls reproduction (GnRH) has helped scientists discover several genes that guide the development and function of the cells that release GnRH. While the findings deepen our understanding of fertility and puberty, they don’t give direct tips for improving health, performance, or longevity in everyday life.
Wang. Fa-Sheng FS; Chen. Hui H; Wu. Zhao-Yang ZY; Lin. Jian-Hua JH
The study examined the protein KISS1 in bone cancer cells and patients. In lab-grown cancer cells, lower KISS1 levels were linked to more aggressive behavior, but in real patients, higher KISS1 levels were found in those with metastasis, making its role unclear.
Katagiri. Fumihiko F; Nagai. Kazuyuki K; Kida. Atsushi A; Tomita. Kenji K; Oishi. Shinya S; Takeyama...
The study found that people with pancreatic cancer have higher levels of a peptide called metastin (kisspeptin‑10) in their blood compared to healthy people, but the amount didn’t relate to how big or advanced the tumor was. This suggests metastin might help detect the disease, but it doesn’t tell us how to use it for health or performance.
Yi. Xue X; Li. Chang-ying CY; Zhang. Su-hua SH; Wang. Xian-hua XH; Li. Zhan-qing ZQ; Yang. Fang F
The study looked at how the protein kisspeptin (KiSS-1) and two other molecules, NF‑kB p50 and MMP‑9, appear in breast cancer tissue. It found that higher kisspeptin levels are linked to less aggressive tumors, while NF‑kB and MMP‑9 rise as cancers get worse. The three markers are inversely related, suggesting kisspein may help keep tumors in check, but the research doesn’t give any practical ways to use kisspeptin for health or performance.
Jiang. Tao T; Zhang. Shu-lan SL; Lin. Bei B; Meng. Li-rong LR; Gao. Hong H
The study looked at two genes, KISS-1 and its receptor GPR54, in uterine cancer tissue. It found that the cancer samples had less KISS-1 activity than non‑cancer tissue, and lower KISS‑1 was linked to more advanced disease, while GPR54 levels didn’t change much. This suggests KISS‑1 might help keep the cancer from spreading, but the research doesn’t tell us how to use this information for health or performance improvement.
Hou. Yuan-Kai YK; Wang. Yi Y; Cong. Wen-Ming WM; Wu. Meng-Chao MC
The study found that a gene called KiSS-1, which makes the peptide kisspeptin, is less active in liver cancer that spreads into the portal vein, while an enzyme called MMP‑9 is more active. Lower KiSS‑1 levels were linked to higher MMP‑9, suggesting KiSS‑1 might help keep cancer from spreading by keeping MMP‑9 low.
Qiao. Chong C; Wang. Chun-hui CH; Shang. Tao T; Lin. Qi-de QD
The study looked at two proteins, kisspeptin (KiSS‑1) and MMP‑9, in placentas from women with preeclampsia. It found that kisspeptin levels were higher and MMP‑9 levels were lower in preeclampsia, especially severe cases, and these changes were linked to higher blood pressure, more protein in urine, eye‑blood‑vessel spasms, and poorer newborn weight. The findings are mainly about pregnancy complications, not about using kisspeptin‑10 for health‑boosting in healthy people.
Wang. Zhan-hui ZH; Feng. Xiao-shan XS; Wang. Gong-ping GP; Gao. She-gan SG; Mi. Jian-qiang JQ; Sun....
The study looked at two proteins, KiSS-1 and E‑cadherin, in stomach‑cardia cancer tissue and found that lower levels of both are linked to more aggressive disease, while higher levels seem to help keep the cancer from spreading.
Qiao. Chong C; Cheng. Da-Li DL; Zhang. Shu-Lan SL; Wang. Chun-Hui CH; Lin. Qi-de QD
The study looked at two proteins, MMP‑9 (which helps cells invade) and kisspeptin‑10 (which blocks invasion), in normal and abnormal pregnancies. Early in pregnancy MMP‑9 is high and kisspeptin is low, then they swap as the pregnancy progresses. In preeclampsia both are low, while in abnormal growths like molar pregnancies MMP‑9 stays high and kisspeptin stays low, and in the most aggressive cancer (choriocarcinoma) kisspeptin isn’t detectable at all. The balance between these two proteins seems to control how much the placenta cells can invade tissue.
Savvidis. Christos C; Papaoiconomou. Eleni E; Petraki. Constantina C; Msaouel. Pavlos P; Koutsilieri...
The study looked at how the KISS1 protein and its receptor behave in thyroid cancer. It found that higher levels of KISS1 appear when the tumor is invading nearby tissue, while lower levels of the receptor (KISS1R) are linked to bigger tumors. The authors think the cancer cells may boost KISS1 to try to stop spreading, but losing KISS1R may let the tumor grow.
Lee. J H JH; Welch. D R DR
Putting the KiSS-1 gene into a breast cancer cell line made those cells far less likely to spread to other organs in mice, cutting metastasis by about 95%, but it didn't stop the original tumor from growing.
Zhuo. Qi Q
This review talks about a hormone called kisspeptin‑10 that controls reproduction in fish. It explains where the hormone is made in the fish brain, the different forms it can take, how it works with other signals, and how it has evolved, but it doesn’t give any tips you can use for human health or performance.
Yao. Hong-liang HL; Yang. Zhu-lin ZL; Li. Yong-guo YG; Liu. Guo-wen GW
The study looked at two genes, Kiss-1 and KAI-1, that can help stop cancer from spreading. In stomach cancer samples, both genes were found at lower levels than in nearby healthy tissue, and the lower the levels, the more advanced the cancer was. The two genes tended to be expressed together.
Mooez. S S; Malik. F A FA; Kayani. M A MA; Rashid. R R; Zahid. A A; Khan. A A
The study looked at two genes that help stop cancer from spreading—KAI1 and KISS1 (which makes the peptide kisspeptin). In breast cancer samples from Pakistani patients, both genes were found at much lower levels than in nearby normal tissue, and a new version of KAI1 was spotted for the first time.
Gao. Guo-lan GL; Liu. Li-dan LD; Zou. Xue-sen XS; Chen. Wen-xue WX
The study looked at a protein called KiSS-1 (kisspeptin) in ovarian tumors and found that higher KiSS-1 levels are linked to lower levels of two other proteins, MMP-9 and NF‑kappaB, which are associated with cancer spread. While KiSS-1 may help suppress tumor metastasis, the research is limited to tissue samples and does not provide any guidance on how to use kisspeptin in everyday health or longevity practices.
Kleynhans. Janke J; Reeve. Robert R; Driver. Cathryn H S CHS; Marjanovic-Painter. Biljana B; Sathekg...
Scientists made a version of the tiny protein kisspeptin‑10 that can be tagged with radioactive metals to help see and possibly treat cancers. Adding the DOTA tag didn’t stop the peptide from working, and it cleared quickly from the blood, making it a promising tool for medical imaging and therapy, but it isn’t something you can use for personal health or performance.
Mashiko. Daisuke D; Tokoro. Mikiko M; Yao. Tatsuma T; Yamagata. Kazuo K
The study shows that giving mice a peptide called kisspeptin-10 during their fertile phase can make them act like they are pregnant without mating, which helps scientists transfer embryos and produce offspring more easily.