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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
González-León. K K; Beltrán-Pérez. G G; Muñoz-Aguirre. S S; López-Gayo...
The paper describes a new lab tool – an optical‑fiber biosensor that can sense kisspeptin, a hormone linked to puberty and cancer, by measuring changes in light transmission. It focuses on how the sensor is built and validated, not on how to use kisspeptin for health or performance.
Del Gobbo. Giulia F GF; Yuan. Victor V; Robinson. Wendy P WP
A newborn boy with very low birth weight was found to have many large, new DNA duplications in his placenta, including extra copies of the KISS1 gene. These genetic changes were mosaic (present in some placental cells but not all) and likely caused the growth problems. The study shows how complex and poorly understood placental genetics can be.
Nikitina. Irina L IL; Yukhlina. Yulia N YN; Vasilieva. Elena Y EY; Nagornaya. Irena I II; Grineva. E...
The study measured kisspeptin levels in the blood of teenage boys with delayed puberty caused by low hormone production, comparing them to normal teens and younger pre‑pubertal boys. It found that boys with this type of delayed puberty had higher kisspeptin levels, and a cutoff value could help diagnose the condition.
Ulasov. Ilya I; Borovjagin. Anton A; Fares. Jawad J; Yakushov. Semyon S; Malin. Dmitry D; Timashev....
This study looks at how a gene called KISS1 (which makes the kisspeptin peptide) interacts with another protein, E‑cadherin, in breast cancer that spreads to the brain. It finds that when KISS1 levels go down, E‑cadherin goes up, and this shift is controlled by a tiny RNA molecule called miR‑345. The work is purely about cancer biology and does not test kisspeptin as a supplement or health‑boosting agent.
Kaverina. Natalya N; Borovjagin. Anton V AV; Kadagidze. Zaira Z; Baryshnikov. Anatoly A; Baryshnikov...
The study shows that brain cells called astrocytes can help breast cancer cells spread to the brain by lowering a protein called kisspeptin, which normally blocks cancer spread. They do this through a chain of signals (CXCL12 → microRNA‑345 → reduced KISS1) that ramps up cell recycling processes (autophagy) and makes the cancer more invasive.
Zhou. Bo B; Huang. Wen-He WH; Chen. Shaoying S; Chen. Weibin W; Peng. Pei P; Zhou. Yanchun Y; Gu. We...
The study shows that a protein called GDF15 can go into the cell nucleus and help turn on the KISS-1 gene by teaming up with another protein, Sp1. This boosts KISS-1 levels and slows down the growth of breast cancer cells in the lab.
Tian. Jun J; Al-Odaini. Amal A AA; Wang. Yun Y; Korah. Juliana J; Dai. Meiou M; Xiao. Lan L; Ali. Su...
The study shows that the small peptide kisspeptin‑10 (KP‑10) can actually make aggressive breast cancer cells more invasive by turning on certain growth pathways, and that blocking the related protein KiSS1 can reduce this effect. This is a cancer‑cell biology finding, not a health‑boosting or performance‑related result.
Takács. Szabolcs S; Bardóczi. Zsuzsanna Z; Skrapits. Katalin K; Göcz. Balázs B;...
Scientists examined the tiny structure of kisspeptin‑producing brain cells in human tissue using a special dye and electron microscopy. They mapped how these cells look, how many branches they have, and what kinds of nerve connections they receive, but the study does not test any health‑boosting uses of kisspeptin.
Platonov. Mikhail E ME; Borovjagin. Anton V AV; Kaverina. Natalya N; Xiao. Ting T; Kadagidze. Zaira...
Scientists put the KISS1 gene into a specially engineered virus and showed that, in lab-grown breast cancer cells that spread to the brain, this virus can make the cancer cells die faster and block blood‑vessel growth that feeds tumors. The work is purely in a petri dish and uses gene‑therapy tools, not a supplement you can take.
Qiu. Jun-Jun JJ; Lin. Xiao-Jing XJ; Tang. Xiao-Yan XY; Zheng. Ting-Ting TT; Zhang. Xu-Yin XY; Hua. K...
Researchers discovered that a long noncoding RNA called TC0101441 is higher in ovarian cancer tissue and pushes the cancer to spread by lowering the levels of the kisspeptin gene (KiSS1). When TC0101441 is blocked, kisspein levels go back up and the cancer cells become less invasive. This finding is about cancer biology, not about everyday health hacks.
Romero-Ruiz. Antonio A; Avendaño. Maria S MS; Dominguez. Francisco F; Lozoya. Teresa T; Molina-...
The study found that a hormone called kisspeptin, which normally rises early in a healthy pregnancy, is much lower in women with ectopic (outside‑the‑uterus) pregnancies. This drop is linked to a tiny RNA molecule (miR‑324‑3p) that suppresses the gene that makes kisspeptin. Measuring both kisspeptin and miR‑324‑3p in blood could accurately tell doctors if a pregnancy is ectopic.
Mondal. Mohan M; Karunakaran. M M; Baruah. Kishore Kumar KK
Scientists created a new lab test to measure the hormone kisspeptin‑10 in the blood of a cattle species called mithun, showing it can detect very low levels and that the hormone rises during pregnancy and follicle growth. This work is about a measurement method for animals, not a health protocol for people.
Schäfer-Somi. S S; Ay. S S SS; Kaya. D D; Sözmen. M M; Beceriklisoy. H B HB; Ağao&#x...
The study looked at how the hormone kisspeptin-10 and its receptor GPR54 are present in the uterus of pregnant dogs at different stages. It found that both proteins are present, but their levels change during pregnancy, with less kisspeptin-10 in the uterus once pregnancy starts and varying amounts of the receptor in different uterine cells.
Zhang. Y-X YX; Cui. H-X HX; Liu. L L; Yi. G-K GK
Scientists found that a molecule called MNX1-AS1, which is a type of long non‑coding RNA, is higher in bone cancer (osteosarcoma) tissue and helps the cancer cells grow and spread by keeping the KISS1 gene turned down. When they reduced MNX1-AS1, the cancer cells grew slower and KISS1 levels went up.
Espigares. F F; Rocha. A A; Gómez. A A; Carrillo. M M; Zanuy. S S
The study looked at how different light schedules change hormone signals that control puberty in male European sea bass, showing that certain light patterns shift the timing of specific brain chemicals (kiss1 and gnrh2) and affect reproductive hormones, but it doesn’t give any direct advice for human health or performance.
Gründker. Carsten C; Bauerschmitz. Gerd G; Knapp. Juliane J; Schmidt. Elena E; Olbrich. Theresa...
In lab experiments, a small protein called kisspeptin‑10 was able to stop another molecule (SDF‑1) from making breast cancer cells more aggressive and invasive. This effect was seen only in cell cultures, not in people.
Mousavi Ardehaie. Reza R; Hashemzadeh. Shahriar S; Behrouz Sharif. Shahin S; Ghojazadeh. Morteza M;...
The study examined DNA changes (methylation) in two genes, EDNRB and KISS1, in colon cancer tissue versus nearby normal tissue. It found that EDNRB is consistently more methylated in tumors and could help detect cancer early, while KISS1 showed no clear difference. This is a diagnostic research finding, not a treatment or lifestyle tip.
Shin. Wui-Jung WJ; Cho. Young-Ah YA; Kang. Kyung-Rim KR; Kim. Ji-Hoon JH; Hong. Seong-Doo SD; Lee. J...
The study found that lower levels of the protein KiSS-1 in oral cancer tissue are linked to more aggressive disease, spread to lymph nodes, and poorer survival, making KiSS-1 a potential marker for how bad the cancer might get.
Uenoyama. Yoshihisa Y; Tomikawa. Junko J; Inoue. Naoko N; Goto. Teppei T; Minabe. Shiori S; Ieda. Na...
The paper reviews how DNA and histone changes control the kisspeptin gene in the brain, which in turn influences puberty and reproductive hormone release. It does not test kisspeptin as a supplement or give any dosing advice.
Kolioulis. I I; Zafrakas. M M; Grimbizis. G G; Miliaras. D D; Timologou. A A; Bontis. J N JN; Tarlat...
The study looked at where a protein called KISS-1 shows up in uterine tissue from women with adenomyosis, a condition where the lining grows into the muscle wall. They found more KISS-1 in the glandular part of the disease tissue and in the normal lining of women who have the disease, but less in the surrounding supportive tissue. This suggests KISS-1 might play a role in the condition, but the research doesn’t tell you how to use kisspeptin‑10 for health or performance.