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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Akhtar. Rana Waseem RW; Shah. Syed Aftab Hussain SAH; Qureshi. Irfan Zia IZ
Giving kisspeptin-10 (KP-10) to male horses, donkeys and mules raised their blood testosterone levels, similar to the effects of hCG and LH. The rise was seen a few hours after injection, showing KP-10 can act like a natural trigger for testosterone production in these animals.
Sun. Jianhua J; Liu. Juxiong J; Huang. Bingxu B; Kan. Xingchi X; Chen. Guangxin G; Wang. Wei W; Fu....
Scientists found that a short piece of the hormone kisspeptin (kisspeptin‑10) can make cow mammary cells produce more of the milk protein beta‑casein. The effect works through the GPR54 receptor and several cell‑signaling pathways (ERK1/2, AKT, mTOR, STAT5). Blocking the receptor or those pathways stops the boost.
Leon. Silvia S; Talbi. Rajae R; McCarthy. Elizabeth A EA; Ferrari. Kaitlin K; Fergani. Chrysanthi C;...
Researchers found that a protein called NHLH2 helps turn on the kisspeptin gene in brain cells that control puberty and fertility. Removing NHLH2 from these cells in male mice delayed puberty and made them more sensitive to metabolic stress, while females were less affected. This shows that kisspeptin production is linked to both reproductive timing and metabolic signals like leptin.
Zhang. Ying Y; Hou. Yuanlong Y; Wang. Xiaoyan X; Ping. Jihui J; Ma. Zhiyu Z; Suo. Chuan C; Lei. Zhih...
A study in rats found that giving kisspeptin-10 changes heart cell shape, causes fibrosis, damages mitochondria, and shifts many blood metabolites and heart‑related genes. These changes point to stress or injury to the heart rather than a health benefit.
Sanchez-Garrido. Miguel Angel MA; Ruiz-Pino. Francisco F; Velasco. Inmaculada I; Barroso. Alexia A;...
The study shows that when fathers are obese, their male offspring who later eat a high‑fat diet gain more weight, have higher leptin, and show weaker hormone (LH) responses to kisspeptin‑10, which could lower testosterone. Female offspring are less affected metabolically, but both sexes have a blunted LH response to kisspeptin. In short, paternal obesity makes the male offspring’s metabolism and reproductive hormone system more vulnerable, and it also dampens how well kisspeptin works.
Franssen. Delphine D; Tena-Sempere. Manuel M
This paper explains that the kisspeptin receptor (Kiss1R) is a key protein that controls when puberty starts, how the body releases reproductive hormones, and how fertility works. Mutations that break this receptor can stop puberty and cause hormone problems. The system also links metabolism and the environment to reproductive health.
Cavadias. Iphigénie I; Rouzier. Roman R; Lerebours. Florence F; Héquet. Delphine D
Women with hormone‑sensitive breast cancer often get hot flashes from their anti‑estrogen treatments. Traditional hormone‑replacement pills can’t be used because they may fuel the cancer. New research suggests that the brain's kisspeptin system may help cause these flashes, and drugs that block a related receptor (NK3) have shown early promise in reducing them in non‑cancer patients, but more studies are needed.
Wang. Tongtong T; Cui. Xueqin X; Xie. Ling L; Xing. Roumei R; You. Panpan P; Zhao. Yongliang Y; Yang...
The study shows that the kisspeptin‑10 peptide, acting through its receptor GPR54, pushes stem cells and fat cells to become more fat‑filled and makes mice gain weight faster on a high‑fat diet. Mice lacking the receptor stay leaner, have smaller fat cells, and less inflammation in their fat tissue.
Aguirre. Rebecca Schneider RS; Eugster. Erica A EA
The paper explains that early puberty (central precocious puberty) happens when the brain's hormone system turns on too soon, and that the kisspeptin pathway is a key driver of this process. Mutations in kisspeptin and related genes can cause this condition. Treatment usually involves GnRH analog drugs to pause puberty and protect height, and newer long‑acting versions are being developed.
Cao. Xin-Yuan XY; Hua. Xu X; Xiong. Jian-Wei JW; Zhu. Wen-Ting WT; Zhang. Jun J; Chen. Ling L
In mice, the antimicrobial chemical triclosan lowered thyroid hormones, which caused a rise in prolactin and shut down kisspeptin signals in the brain. This chain reaction messed up the hormones that control ovulation and stopped normal menstrual cycles. Giving the mice thyroid hormone (levothyroxine), a dopamine‑type drug, or the peptide kisspeptin‑10 fixed the kisspeptin drop and restored fertility hormones.
Aslan. M M; Erkanli Senturk. G G; Akkaya. H H; Sahin. S S; Yılmaz. B B
In a rat study, giving oxytocin or a short form of kisspeptin (kisspeptin-10) before a brief loss of blood flow to the ovaries and uterus helped protect those organs from damage. The treatment lowered markers of oxidative stress and boosted the organs' natural antioxidant defenses.
Zhou. Zhiyang Z; Lin. Qi Q; Xu. Xinxin X; Illahi. Gaby Sukma GS; Dong. Chenle C; Wu. Xueqing X
A study in rats found that mothers eating a high‑fat diet during pregnancy can mess up their babies' ovarian development later in life. The offspring showed changes in follicle numbers, earlier puberty, and irregular cycles, which were linked to higher levels of the hormone‑like peptide kisspeptin in the ovary. When researchers added kisspeptin‑10 to ovarian cells in a dish, the cells survived better and the eggs grew larger.
Saito. Reiko R; Tanaka. Kentaro K; Nishimura. Haruki H; Nishimura. Kazuaki K; Sonoda. Satomi S; Ueno...
Giving rats a dose of kisspeptin-10 directly into the brain made them eat less for a few hours. The effect seems to happen because kisspeptin turns on two other brain chemicals, nesfatin‑1 and oxytocin, that are known to reduce hunger. Blocking these downstream signals lessened the appetite‑suppressing effect.
Abou Khalil. Nasser S NS; Mahmoud. Gamal B GB
A short‑term study in male sheep showed that weekly injections of kisspeptin‑10 (5 µg per kg body weight) for one month improved semen quality, increased testosterone, and boosted several blood markers of antioxidant capacity and metabolism. The changes were seen only in the treated rams and not in untreated controls.
Bowe. James E JE; Hill. Thomas G TG; Hunt. Katharine F KF; Smith. Lorna If LI; Simpson. Sian Js SJ;...
The study shows that kisspeptin, a hormone released by the placenta, helps the pancreas make more insulin during pregnancy. Blocking kisspeptin in pregnant mice caused higher blood sugar because the pancreas didn't release enough insulin. In pregnant women, higher kisspeptin levels were linked to better insulin responses, and women with gestational diabetes had lower kisspeptin.
Hugon-Rodin. Justine J; Yoshii. Keisuke K; Lahlou. Najiba N; Flandrin. Jennifer J; Gompel. Anne A; d...
A woman with a rare genetic defect that disables the kisspeptin receptor was still able to ovulate and get pregnant after receiving pulsatile GnRH therapy, showing that the body can trigger the LH surge without kisspeptin signaling.
Rehman. Rehana R; Fatima. Syeda S SS; Alam. Faiza F; Ashraf. Mussarat M; Zafar. Shaheen S
The study found that people who can conceive naturally have higher blood levels of the hormone kisspeptin and other reproductive hormones than those who are infertile, and that certain genetic variations in the kisspeptin gene are linked to lower hormone levels and infertility.
Mijiddorj. Tselmeg T; Kanasaki. Haruhiko H; Oride. Aki A; Hara. Tomomi T; Sukhbaatar. Unurjargal U;...
The study shows that kisspeptin-10 can directly boost the production of hormone subunits that make up LH and FSH in mouse pituitary cells, acting similarly to GnRH. When combined with another peptide, ADCYAP1, the effect is even stronger. Kisspeptin also raises the levels of its own receptor, suggesting a feedback loop.
Gibula-Bruzda. Ewa E; Marszalek-Grabska. Marta M; Gawel. Kinga K; Trzcinska. Roza R; Silberring. Jer...
Researchers created a new peptide called kissorphin (KSO) from kisspeptin-10 and found that, in mice, it can calm down the extra activity caused by alcohol or morphine and can also block the development of increased sensitivity to these drugs after repeated use. The effect depends on the same receptors that natural neuropeptide FF uses, and it doesn't mess with basic motor skills.
Aquino. Nayara S S NSS; Kokay. Ilona C IC; Perez. Carolina Thörn CT; Ladyman. Sharon R SR; Henr...
The study shows that kisspeptin-10 can boost prolactin levels, but it does this through the Kiss1 receptor in brain cells that are not the usual dopamine‑producing neurons that control prolactin. The dopamine‑producing (TIDA) neurons don’t have the Kiss1 receptor and don’t react directly to kisspeptin, suggesting the hormone works via other brain pathways.