Shahab. Muhammad M; Lippincott. Margaret M; Chan. Yee-Ming YM; Davies. Addie A; Merino. Paulina M PM...
A rare genetic mutation that weakens kisspeptin signaling caused a boy to have a tiny penis and undescended testes as a baby, but he later went through normal puberty as a teen. This shows that early infant hormone bursts rely more on kisspeptin than the later teen puberty does.
Liu. Hongyu H; Xu. Gaoqing G; Yuan. Zhiyu Z; Dong. Yangyunyi Y; Wang. Jun J; Lu. Wenfa W
The study shows that kisspeptin‑10, a small protein, is present in cow ovarian cells and at a concentration of 100 nM it slows down cell growth and triggers cell death by altering the cell cycle and death‑related genes. This work is done in isolated bovine cells, not in people, so it doesn’t give direct tips you can use for health, longevity, or performance.
Schäfer-Somi. Sabine S; Kaya. Duygu D; Sözmen. Mahmut M; Kaya. Semra S; Aslan. Selim S
Researchers gave a GnRH‑activating drug (deslorelin) to young female dogs and later examined their uteruses. The drug didn’t cause any obvious uterine problems, and the natural kisspeptin‑10 protein was found at low levels, mainly in blood vessels. Some hormone receptors were higher in dogs treated before puberty, but overall the findings don’t give direct advice for people using kisspeptin‑10.
Leonardi. Carlos E P CEP; Dias. Fernanda C F FCF; Adams. Gregg P GP; Araujo. Estela R ER; Singh. Jas...
In a study with young cows, a short version of the human hormone kisspeptin (kisspeptin‑10) was given through an IV. It caused a quick rise in the hormone LH and made some cows ovulate, working better than the mouse version of the peptide and almost as well as the standard fertility drug GnRH.
Taniguchi-Ponciano. Keiko K; Ribas-Aparicio. Rosa María RM; Marrero-Rodríguez. Daniel D; A...
Researchers found that the KISS1 gene, which makes the peptide kisspeptin, is often higher in cervical cancer tissue, showing a genetic increase and more messenger RNA, but this doesn’t change based on HPV infection. They think KISS1 could become a useful marker or drug target for this cancer, though no treatment steps are described.
Researchers found that a peptide called kisspeptin‑10 can change hormone production and how sperm stick to support cells in frog testes, but giving it to live frogs didn’t make sperm get released. The work is basic science in amphibians and doesn’t give clear guidance for human use.
Ulasov. Ilya V IV; Borovjagin. Anton V AV; Timashev. Peter P; Cristofanili. Massimo M; Welch. Danny...
KISS1 (the source of kisspeptin-10) is a protein that normally helps keep cells from spreading and forming new tumors. In many cancers, especially breast cancer, its levels are lower, which may let cancer cells spread more easily. The protein also seems to influence how cancer cells manage stress, grow new blood vessels, and die, making it a possible marker for cancer progression and a future drug target, but there are no clear ways to use this information right now.
Hu. Kai-Lun KL; Chang. Hsun-Ming HM; Zhao. Hong-Cui HC; Yu. Yang Y; Li. Rong R; Qiao. Jie J
Kisspeptin is a hormone that helps control the start of puberty and fertility, and new research shows it also plays a role in how an embryo sticks to the uterus and how the placenta forms. Changes in kisspeptin levels might signal problems like miscarriage or certain pregnancy cancers, but the studies are still early and mostly about using it as a diagnostic marker, not a treatment you can take yourself.
Huma. Tanzeel T; Hu. Xintian X; Ma. Yuanye Y; Willden. Andrew A; Rizak. Joshua J; Shahab. Muhammad M...
Researchers gave kisspeptin‑10 to monkey stem cells and saw the cells stop dividing, change shape, and become neuron‑like cells that produce GnRH, the hormone that controls reproduction. This shows kisspeptin can steer stem cells toward a reproductive‑brain cell type, but it’s all in a lab dish and far from a human treatment.
Zhu. Bo B; Wang. Yichao Y; Wang. Xiaolin X; Wu. Shiwu S; Zhou. Lei L; Gong. Xiaomeng X; Song. Wenqin...
The study looked at four proteins in colon cancer tissue, including KiSS-1 (the gene that makes the kisspeptin peptide). It found that higher levels of KiSS-1 were linked to smaller tumors and better survival, while the other three proteins were linked to worse outcomes. This is mainly a cancer‑research finding and doesn’t give direct advice for using kisspeptin‑10 to boost health or performance.
Canton. Ana Pinheiro Machado APM; Seraphim. Carlos Eduardo CE; Brito. Vinicius Nahime VN; Latronico....
The study shows that rare genetic mutations in the kisspeptin signaling pathway (KISS1/KISS1R) and in the imprinted genes MKRN3 and DLK1 can cause children to start puberty much earlier than normal. These mutations are mostly found in families where several members have early puberty, and the clinical picture looks the same as regular (idiopathic) early puberty. The DLK1 mutation also seems linked to adult metabolic problems like obesity and early‑onset diabetes.
Ziyaraa. Maysoun A MA; Hamdan. Farqad B FB; Mousa. Liqaa R LR
In pregnant women, lower blood levels of the peptide kisspeptin‑10 are linked to preeclampsia and its severity, and the levels also relate to how well the baby is growing.
Stathaki. Martha M; Stamatiou. Maria Evanthia ME; Magioris. George G; Simantiris. Spyridon S; Syrigo...
Kisspeptin-10 is a brain‑derived peptide best known for triggering puberty and ovulation. Scientists have also found that it can slow the spread of some cancers in lab studies, and they are exploring ways to use it as a cancer treatment. However, the research is still early and does not give any clear instructions for personal use.
Zielinska-Gorska. M M; Gorski. K K; Biernacka. K K; Sawosy. E E; Kaminska. T T; Gajewska. A A
In female rats, giving GnRH or kisspeptin-10 directly into the brain changed the activity of certain genes in the pituitary gland that control hormone production. GnRH boosted a gene called Nr5a1 and a signaling protein (Ctnnb1), while kisspeptin-10 raised a different gene, Nr0b1. These shifts suggest the two peptides can fine‑tune pituitary cell function, but the work was done in rats with brain infusions, not in humans.
Golzar. Fatemeh F; Javanmard. Shaghayegh Haghjooy SH; Bahrambeigi. Vahid V; Rafiee. Laleh L
Researchers found that a short form of the hormone kisspeptin (kisspeptin‑10) can change how stem cells move: a low dose (about 100 nM) makes them migrate more, while a higher dose (500 nM) slows them down, likely by altering a cell‑surface receptor called CXCR4. The work was done in lab dishes and mice, not people.
Martino. N A NA; Rizzo. A A; Pizzi. F F; Dell'Aquila. M E ME; Sciorsci. R L RL
Researchers tested kisspeptin‑10 on cow placental cells grown in the lab and found it could either slow down or speed up cell growth, depending on how much of the kisspeptin receptor the cells had. It didn’t change progesterone levels. The work is basic and done in bovine tissue, so it doesn’t give clear guidance for human use.
Ross. Rachel A RA; Leon. Silvia S; Madara. Joseph C JC; Schafer. Danielle D; Fergani. Chrysanthi C;...
Scientists found that a brain chemical called PACAP, made by specific neurons, talks to kisspeptin cells that control fertility. Removing PACAP from those neurons in female mice delayed puberty and messed up their ability to reproduce, while males were unaffected. This suggests PACAP helps link nutrition signals to reproductive hormones in females.
Hu. Kai-Lun KL; Zhang. Yongli Y; Yang. Zi Z; Zhao. Hongcui H; Xu. Huiyu H; Yu. Yang Y; Li. Rong R
Researchers measured kisspeptin levels in women after a frozen‑thawed embryo transfer to see if the hormone could predict whether a pregnancy would take hold. They found that kisspeptin levels change over time, but the test was not good at forecasting miscarriage and didn’t add much beyond the usual hCG test.
In a mouse hypothalamus cell line, the hormone-like peptide RFRP-3 was found to boost the gene that makes kisspeptin, a key regulator of reproductive hormones. The effect was seen in cells that also respond to estrogen and melatonin, but the study was done only in a dish, not in people.
Horstmann. Marcus M; Krause. Felix F; Steinbach. Daniel D; Twelker. Lars L; Grimm. Marc-Oliver MO
Researchers measured a blood molecule called kisspeptin‑10 in people with very small kidney tumors and found it was higher than in healthy folks, with levels differing between tumor types, but the study doesn’t give any tips you can use for health or performance.