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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
Qureshi. I Z IZ; Fatima. I I
In a study with diabetic rhesus monkeys, giving the peptide kisspeptinâ10 (KPâ10) before an insulin dose, or mixing it with insulin, kept blood sugar from dropping too low. Giving KPâ10 after insulin didnât help and actually made glucose fall more. Blocking kisspeptin stopped the protective effect.
Ramzan. Muhammad Haris MH; Ramzan. Muhammad M; Ramzan. Faiqah F; Wahab. Fazal F; Jelani. Musharraf M...
The study measured blood levels of the hormone-like peptide kisspeptin in 176 men and found that men with any type of infertility had significantly lower kisspeptin compared to fertile men. Lower kisspeptin went handâinâhand with lower LH and testosterone, while FSH was only lower in some subâgroups.
Arai. Amy C AC; Xia. Yan-Fang YF; Suzuki. Erika E; Kessler. Markus M; Civelli. Olivier O; Nothacker....
The study shows that the peptide kisspeptin-10 (also called metastin) can boost the strength of excitatory signals in a part of the brain important for memory (the dentate gyrus of the hippocampus). It does this by acting on a specific receptor (GPR54) and turning on a chain of enzymes called MAP kinases, but the effect is seen only in lab brain slices, not in living people.
Stafford. Lewis Joe LJ; Xia. Chunzhi C; Ma. Wenbin W; Cai. Yi Y; Liu. Mingyao M
Scientists discovered that the short peptide kisspeptin-10, which is almost the same in mice and humans, can bind to a special receptor and turn on a cell signaling pathway that reduces cell growth and movement. This effect could help stop cancer cells from spreading, but the study was done in mouse cells and didnât test any realâworld dosing or safety in people.
Muir. A I AI; Chamberlain. L L; Elshourbagy. N A NA; Michalovich. D D; Moore. D J DJ; Calamari. A A;...
Scientists found a new human brain receptor called AXOR12 that is very similar to a mouse receptor known to bind kisspeptin. They showed that kisspeptinâ10 (a piece of the KiSSâ1 protein) can strongly activate this receptor, and that both the receptor and the KiSSâ1 gene are most abundant in brain, pituitary and placenta.
Dungan. Heather M HM; Clifton. Donald K DK; Steiner. Robert A RA
Kisspeptin is a brain chemical that talks to a receptor called GPR54 and tells the hormoneâreleasing center (GnRH) to fire, which then makes the pituitary release sex hormones. Itâs found in two brain spots that react opposite ways to estrogen and testosterone, helping control both the regular hormone feedback loop and the big hormone surge that triggers ovulation. Levels of kisspeptin and its receptor jump up at puberty, showing itâs a key driver of the start of reproductive function.
Serhatlioglu. Ihsan I; Yuksel. Hande H; Kacar. Emine E; Ozcan. Sibel S; Canpolat. Sinan S; Ozcan. Me...
The study shows that a short form of the hormone kisspeptin (kisspeptinâ10) can make rat brain cells from the hippocampus fire a quick burst of calcium inside the cell, and this effect depends on a signaling protein called PKC. Blocking PKC stops the calcium rise, meaning kisspeptin works through that pathway.
Gimeno-Martos. Silvia S; Gómez-León. Alicia A; Luigia. Bosa B; Lorenzo. Pedro L PL; Mar&#x...
In a rabbit study, the peptide kisspeptinâ10 (Kp10) was able to trigger ovulation almost as well as the standard GnRH drug, producing similar numbers of eggs and luteal structures. However, the hormone levels after ovulation were lower than with GnRH, and the work was done only in female rabbits.
Fayyaz. Muhammad Hammad MH; Andrabi. Syed Murtaza Hassan SMH; Haider. Muhammad Shafiq MS; Khalique....
Adding kisspeptin-10 to the freezing solution for buffalo bull sperm helped protect the cells from damage during thawing. The best results were seen with 15â20âŻÂ”molâŻLâ»Âč, which boosted antioxidant levels, reduced lipid oxidation, and improved sperm movement, membrane health, and DNA integrity.
Rodríguez-Sarmiento. Deisy Yurley DY; Rondón-Villarreal. Paola P; Scarpelli-Pereira. Pedro...
Scientists tested versions of a small protein called kisspeptinâ10 on cervical cancer cells and found they slowed the cells' growth and movement by tweaking signaling pathways, but the work was done only in lab dishes and not in people.
Roosta. Zahra Z; Unniappan. Suraj S; Uju. Chinelo C; Rahmati. Mehdi M; Falahatkar. Bahram B
Giving kisspeptinâ10 to Sterlet sturgeon changed some hormone and metabolism numbers â it raised estradiol, vitellogenin, calcium, glucose and blood fats, but didnât affect testosterone or body weight. The peptide also helped more eggs mature in the fish.
Wang. Tingting T; Lu. Wengui W; Cheng. Zhifei Z; Wang. Luyao L; Jiang. Zhenzhen Z; Yue. Yike Y; Jian...
Scientists made a tiny, pillâlike particle that can travel from the gut to the brain and swap excess copper for zinc and curcumin. In mice with Wilson's disease (a rare condition where copper builds up), this particle reduced brain copper, lowered inflammation, and helped fix reproductive problems. The particle uses kisspeptinâ10 to find hypothalamus cells, but the whole system is still experimental and far from a DIY protocol.
Zhang. XiaoLei X; Wang. Yu Y; Lv. Jia J
The study shows that a protein called STAT4 can protect brain cells from damage in a mouse model of Parkinson's disease, but it does this by turning off another protein called KISS1. When KISS1 is turned back on, the protection disappears, suggesting that KISS1 may actually worsen oxidative stress, inflammation, and cell death in the brain.
Shah. Hetvi H; Pillai. Pranav P; Buch. Lipi L; Ramachandran. A V AV; Pandya. Parth P
Scientists studied how the protein KISS1 (and its short piece kisspeptinâ10) interacts with DNAâbinding proteins that drive cancer spread. In lab breastâcancer cells, kisspeptinâ10 at about 100âŻnM changed the activity of several transcription factors, boosting some that may suppress metastasis and lowering others that promote it. The work shows a possible antiâcancer effect but does not give any humanâusable dosing or safety info.
Szysiak. Natalia N; Kosior-Korzecka. Urszula U; Greguła-Kania. Monika M; Patkowski. Krzysztof...
In a lab test using cells from young female sheep, the researchers found that adding the neuropeptide neurokinin B (NKB) caused the cells to release more kisspeptin-10, a hormone involved in reproductive signaling. The effect depended on how much NKB was added and how long the cells were exposed. The related peptide dynorphin A did not change kisspeptin-10 release at any dose.
Harihar. Sitaram S; Welch. Danny R DR
The paper reviews how the KISS1 gene can keep cancer cells in a dormant, nonâgrowing state and discusses the idea of using it as a new way to treat metastatic cancer. It does not provide any direct advice on how to use kisspeptinâ10 or related peptides for health, performance, or longevity.
Radwańska. Paulina P; Gałdyszyńska. Małgorzata M; Piera. Lucyna L; Drobnik....
The study shows that the peptide kisspeptinâ10 makes heart cells produce more collagen, which can lead to stiffening or scarring of the heart. It does this by turning on a protein called FAK and by blocking enzymes that normally break down collagen. This effect is not linked to the usual TGFâÎČ pathway.
Guo. Chenfan C; Wu. Gun G; Liu. Tao T
Scientists found that a small protein called kisspeptinâ10 (KPâ10) can slow down the growth and spread of esophageal cancer cells in the lab. It works by turning off a cellâcommunication pathway (Wnt/ÎČâcatenin) that cancer cells use to grow, and this effect depends on another protein called SIX1. However, the study was done only in cell cultures, not in people, so it doesnât give any direct advice you can use right now.
Shi. Haixia H; Yan. Zunqiang Z; Du. Hong H; Tang. Yuran Y; Song. Kelin K; Yang. Qiaoli Q; Huang. Xia...
The study looked at a gene called Kiss1 that makes the peptide kisspeptin in pig testes. It found that kisspeptin levels go up after puberty and that the protein is mainly in cells that make testosterone and developing sperm. The research shows kisspeptin helps start puberty and sperm production in boars, but it doesnât give any tips you can use right now.
Valizadeh. Mehdi M; Babaei. Esmaeil E; Sharifi. Rasoul R; Yazdanbod. Abbas A
The study found that a small RNA called miR-650 is usually low in colon cancer tissue, but chemotherapy drug 5âFU can raise its levels. When both miR-650 and 5âFU are present, they lower the amount of a protein called KISS1 and cause cancer cells to die in lab dishes. However, this work is earlyâstage and done in cells, not people, so it doesnât give a clear way for individuals to use kisspeptinâ10 or miRâ650 for health benefits.