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ACTH(4-10) analogue, Heptapeptide SEMAX
A synthetic heptapeptide analog of ACTH(4-10) that provides nootropic, neuroprotective, and cognitive-enhancing effects by modulating BDNF and neurotransmitter systems.
Ponomareva-Stepnaia. M A MA; Porunkevich. E A EA; Skuin'sh. A A AA; Nezavibat'ko. V N VN; Ashmarin....
The study checked if semax, a short ACTH fragment used by some biohackers, triggers hormone production. It found that semax does not boost steroid hormones or melanin, meaning it likely won’t cause cortisol spikes or skin‑pigment changes.
Cherkasova. K A KA; Lyapina. L A LA; Ashmarin. I P IP
In a short‑term rat study, giving the peptide Semax (and related proline‑rich peptides) through the nose boosted the blood’s ability to prevent clots and to break them down, and it made experimentally formed clots smaller.
Gavrilova. S A SA; Golubeva. A V AV; Lipina. T V TV; Fominykh. E S ES; Shornikova. M V MV; Postnikov...
In rats that had a heart attack, giving the peptide semax for a week after the event helped keep the heart from getting too stiff and reduced some of the harmful growth of heart muscle cells. It didn’t change how hard the heart pumped overall, but it did improve the way the heart remodeled itself over the next month.
Shakova. Fatima M FM; Kirova. Yuliya I YI; Silachev. Denis N DN; Romanova. Galina A GA; Morozov. Ser...
In a rat study, giving the peptide Semax through the nose helped protect brain cells after a stroke-like injury. It kept the levels of a protein called PGC‑1α (which supports mitochondria, blood vessels, and synapses) higher than in untreated rats, and more neurons survived.
Romanova. G A GA; Shakova. F M FM; Davydova. T V TV
In a rat study, giving the peptide semax through the nose after a stroke‑like injury helped shrink the damaged brain area and kept the animals from forgetting a learned task. The effect was similar to that of an anti‑glutamate antibody.
Liapina. L A LA; Pastorova. V E VE; Obergan. T Iu TIu; Samonina. G E GE; Ashmarin. I P IP; Miasoedov...
The study looked at how certain small proteins called regulatory proline‑containing oligopeptides, including semax, affect blood clotting. It found that these peptides can have different anticoagulant (blood‑thinning) effects depending on their exact structure, suggesting they might be useful in medical settings that need to control clotting.
Levitskaia. N G NG; Sebentsova. E A EA; Andreeva. L A LA; Alfeeva. L Iu LIu; Kamenskiĭ. A A AA...
In rats, a tiny peptide called semax given through the nose helped protect brain dopamine cells from damage caused by a toxin, keeping the animals more active and less anxious.
Iasnetsov. V V VV; Provornova. N A NA
Researchers found a way to cause memory loss in mice by forcing them to swim in cold water while a wheel spins. When they gave the mice certain brain‑boosting compounds—including the peptide semax—the mice did not develop the memory loss. This suggests semax might protect against extreme stress‑related memory problems, at least in animals.
Fadiukova. O E OE; Alekseev. A A AA; Bashkatova. V G VG; Tolordava. I A IA; Kuzenkov. V S VS; Mikoia...
In rats that had reduced blood flow to the brain, a spike in nitric oxide (NO) and some damage‑related chemicals showed up, and the animals displayed neurological problems. Giving them the synthetic peptide semax (0.3 mg per kg) stopped the NO surge and prevented the brain‑related symptoms.
Zhuikova. S E SE; Smirnova. E A EA; Bakaeva. Z V ZV; Samonina. G E GE; Ashmarin. I P IP
In rats, a single injection of the peptide Semax (50 µg per kg) given an hour before a stomach‑damaging challenge protected the stomach lining, and a five‑day course after an acid injury helped prevent ulcers and speed up healing. Its effect was similar to another small peptide known to protect the gut.
Gusev. E I EI; Skvortsova. V I VI; Miasoedov. N F NF; Nezavibat'ko. V N VN; Zhuravleva. E Iu EIu; Va...
A small clinical study gave the peptide semax to stroke patients and saw a modest speed‑up in recovery of brain function, especially movement, when added to standard care. The best results were with 12 mg daily for moderate strokes and 18 mg daily for severe strokes over 5‑10 days.
Umriukhin. P E PE; Koplik. E V EV; Grivennikov. I A IA; Miasoedov. N F NF; Sudakov. K V KV
In rats, the peptide Semax (an ACTH fragment) changes activity of a stress‑related gene called c‑Fos in brain areas that control emotion. It boosts c‑Fos in some regions under normal conditions, but when the animals are stressed it reduces the stress‑induced c‑Fos response, especially in rats that are naturally more prone to stress. This suggests Semax may have calming, anti‑stress effects in the brain.
Sebentsova. E A EA; Denisenko. A V AV; Levitskaia. N G NG; Andreeva. L A LA; Kamenskiĭ. A A AA...
In a study on baby rats, giving the peptide semax every day for two weeks after birth led to lasting changes: the rats were more curious, less anxious, and learned better later on. This suggests semax can influence brain development, but the research was done in newborn rats, not humans.
Ashmarin. I P IP
The paper reviews a group of short peptides that affect blood clotting, protect mucous membranes, act as brain protectors, improve memory, change behavior, and boost lymph flow. Most of the data come from early‑stage studies and are presented as a broad overview rather than specific dosing or usage guidelines.
Alekseeva. G V GV; Bottaev. N A NA; Goroshkova. V V VV
A study gave the brain‑active peptide semax to 73 people who had suffered oxygen‑deprivation injuries. It helped those with memory problems, especially when combined with an adaptogen called oxiterm and a technique called supraorbital electrophoresis. However, some patients showed abnormal brain waves after the first dose, so careful monitoring is advised.
Ashmarin. I P IP; Bakaeva. Z V ZV; Vas'kovskiĭ. B V BV; Zheliaznik. N Ia NIa; Zhuĭkova....
Researchers found a new group of tiny proteins called glyprolines that are very stable, can get into the bloodstream when taken by mouth, and showed promising anti‑ulcer, blood‑clot‑preventing, and blood‑sugar‑lowering effects in rats. They compared these to similar short peptides and discussed how they might be mixed with protein‑rich foods for future drug development.
Chepurnov. S A SA; Chepurnova. N E NE; Artiukhova. M V MV; Kuznetsova. E Iu EIu; Nezavibat'ko. V N V...
In rats, the peptide ACTH4-7 pro‑gly‑pro (the core of semax) showed some anti‑seizure activity in a lab model where repeated brain stimulation creates seizures, but it actually made seizures happen more easily in a different rat model that is prone to sound‑triggered seizures and didn’t stop the full‑body convulsions.
Chepurnova. N E NE; Guseva. A A AA; Efimova. E V EV; Mart'ianov. A A AA; Chepurnov. S A SA
In rats, giving tiny amounts of the brain chemicals TRH and a short piece of the ACTH hormone (the part used to make the nootropic peptide semax) made them learn maze tasks faster and remember them better, without the two drugs messing with each other's effects.
Sharonova. I N IN; Bukanova. Yu V YV; Myasoedov. N F NF; Skrebitskii. V G VG
In a lab test on rat brain cells, the peptide semax changed how two brain chemicals work: it boosted the effect of GABA (a calming signal) and reduced the effect of glycine (another signal). These changes happened slowly and weren’t easily reversed, hinting at deeper cellular pathways, but the study was done in isolated neurons, not in living animals or people.
Vyunova. Tatiana V TV; Andreeva. Ludmila A LA; Shevchenko. Konstantin V KV; Glazova. Nataliya Yu NY;...
Scientists tested synthetic ACTH fragments like semax on rat brain GABA receptors and found each peptide changes GABA binding differently, but they didn’t stop the stress‑induced drop in low‑affinity GABA binding.