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ACTH(4-10) analogue, Heptapeptide SEMAX
A synthetic heptapeptide analog of ACTH(4-10) that provides nootropic, neuroprotective, and cognitive-enhancing effects by modulating BDNF and neurotransmitter systems.
Boyarshinova. O S OS; Perepelkina. O V OV; Markina. N V NV; Poletaeva. I I II
Giving newborn mice a peptide called semax for a few days lowered the chance they would have seizures triggered by loud sounds, but this only happened in one specific mouse strain (DBA/2J) and not in four other strains.
Timoshenko. T V TV; Perepelkina. O V OV; Markina. N V NV; Revischin. A V AV; Pavlova. G V GV; Poleta...
In newborn rats, giving the peptide semax (or a nitric‑oxide blocker) for a few days boosted brain cell growth in a part of the hippocampus and later changed how the animals responded to sound‑triggered seizures, but the severity of seizures varied depending on the rat strain. The changes weren’t simply tied to how much new brain cells formed, hinting at other underlying mechanisms.
Boyarshinova. O S OS; Shilova. O B OB; Markina. N V NV; Gichenok. I V IV; Perepelkina. O V OV; Polet...
In a mouse study, giving newborns a drug called Semax changed how sensitive they were to pain as adults, but only in certain male mouse strains. Giving just water or salt solution to newborns also altered pain sensitivity in some strains, while another drug, buspiron, lowered pain thresholds in a different strain. These effects were specific to the mouse genetics and sex.
Maslova. M V MV; Graf. A V AV; Sokolova. N A NA; Goncharenko. E N EN; Shestakova. S V SV; Kudryashov...
A study in rats showed that low oxygen levels during pregnancy can mess up brain chemicals important for stress and mood in the pups, and that giving the mother a nasal spray of the peptide semax (and another peptide) prevented these changes. This was an animal experiment, not a human trial, and it focused on prenatal brain development rather than adult health.
Liu. Rongjie R; Chen. Yituo Y; Huang. Haosheng H; Li. Xiang X; Lv. Junlei J; Jiang. Liting L; Jiang....
In female mice with a spinal cord injury, the synthetic peptide Semax helped the animals recover better. It seems to work by binding to the mu‑opioid receptor, which then influences a protein called USP18 and reduces harmful changes to other proteins involved in cell stress. The study was done in mice and cell cultures, not in people.
Medvedeva. E V EV; Dmitrieva. V G VG; Povarova. O V OV; Limborskaia. S A SA; Skvortsova. V I VI; Mia...
A study in rats showed that the tiny peptide Pro‑Gly‑Pro (a part of the drug Semax) changes the activity of many genes in the brain after a stroke, especially lowering immune‑related genes after 24 hours. This was done in a lab model of brain injury, not in healthy people.
Poletaeva. I I II; Perepelkina. O V OV; Boiarshinova. O S OS; Lil'p. I G IG; Markina. N V NV; Timosh...
Giving the brain‑boosting peptide Semax to newborn mice changes how they behave as adults, affecting things like seizure risk, anxiety, curiosity and pain feeling. Some of these changes are the same as what you’d see if you gave the drug to grown‑up animals, while others are the opposite. The effects also depend on the animal’s genetics, suggesting early brain development is very sensitive to such drugs.
Nazarova. G A GA; Konchugova. T V TV; Iurova. O V OV; Turova. E A EA; Rassulova. M A MA; Sichinava....
A study on 114 people with early-stage diabetic eye disease found that delivering the brain‑active peptide semax through a special nose‑based electric method improved vision tests and lasted up to a year, better than regular nasal drops or just standard diabetes meds.
Severyanova. L A LA; Kryukov. A A AA; Plotnikov. D V DV; Dolgintsev. M E ME
In rats, the peptide Semax (ACTH4‑7‑PGP) showed mixed effects on pain: it made them more sensitive to a hot plate test but reduced pain‑related reactions in other shock‑based tests, especially when given directly into the brain.
Sebentsova. E A EA; Glazova. N Iu NIu; Levitskaia. N G NG; Andreeva. L A LA; Alfeeva. L Iu LIu; Kame...
In rats, giving the peptide semax during the first three weeks after birth changes how they behave as teenagers and adults: a dose in the first week makes them explore less later, while doses in weeks two or three make them explore more. No matter when it’s given, it also lowers anxiety and improves learning when they grow up. These results come from newborn rats, not humans, and they don’t tell us how to use semax safely or effectively in adults.
Iasnetsov. V V VV; Krylova. I N IN; Popov. V M VM
In rats, strong stressors like intense electromagnetic fields, motion sickness, and electric shocks wiped out memory, but many racetam‑type nootropics stopped this loss. Semax only helped in a couple of the stress tests, not across the board, so its protective effect seems limited.
Kamkin. A G AG; Kiseleva. I S IS; Kositskiĭ. G I GI
The study looked at tiny pieces of the hormone ACTH and how they change the way snail nerve cells talk to each other, showing that different fragments can make the connection more one‑way or affect how strong the signal is, but it was done in snails and not humans.
Bastrikova. N A NA; Shestakova. S V SV; Antonova. S V SV; Krushinskaia. Ia V IaV; Goncharenko. E N E...
In rats that suffered severe blood loss, the drug semax helped keep spleen serotonin levels from dropping a week after the injury. The study also showed changes in stress hormones and oxidative stress after the shock, but these findings are specific to an acute trauma model and not directly useful for everyday health or performance goals.
Ivanov. Iu V IuV
In a rat study, giving a single dose of the peptide semax directly into the pancreas helped protect the organ during severe inflammation (acute pancreatitis). It reduced tissue death and limited harmful infection, keeping more of the pancreas healthy.
Alekseev. V V VV; Koshelev. V B VB; Kovalev. G I GI; Poletaeva. I I II
A study in newborn rats gave them a peptide called Semax and later measured how they responded to pain and loud sounds as adults. The peptide changed how sensitive the rats were to sound, but it didn't affect their early motor development. Overall, the findings are about how early‑life exposure can shape brain function, not about using Semax in grown‑up humans.
Shilova. O B OB; Markina. N V NV; Perepelkina. O V OV; Gichenok. I V IV; Korochkin. L I LI; Poletaev...
A study gave newborn mice tiny doses of the peptide semax or just salty water and later checked how they behaved in an open arena as adults. Both treatments changed things like freezing, grooming, and exploring, but the effects varied a lot depending on the mouse strain. In some strains, semax seemed to offset some of the changes caused by the saline injections, but overall the results were mixed and hard to interpret.
Ivanov. Iu V IuV; Iasnetsov. V V VV
In a rat study, giving the peptide semax (or the drug mexidol) after the pancreas was damaged sharply lowered death rates and helped the organ heal faster. The benefits were seen when the drug was injected directly into the pancreas or into the belly cavity, and semax performed better than several other drugs tested.
Charland. Scott L SL; Stanek. Eric J EJ
This study looks at how lowering LDL cholesterol with statins affects heart attack risk, using a special curve model. It doesn’t involve the peptide semax at all, so it isn’t useful for people interested in semax or biohacking protocols.
Chen. Teng T; Cheng. Xiang X; Cai. Jun J; Gong. De D; Gong. Weilu W; Yang. Pengyuan P; Wang. Jiancho...
The study describes a new type of flexible, conductive film made from silver nanowires, MXene, and a nickel‑cobalt compound, designed for better electromagnetic interference shielding and heating. It focuses on material engineering, not on the peptide semax or any health‑related effects, so it offers no actionable information for biohackers or longevity enthusiasts.
Toumi. Khaoula K; Joly. Laure L; Vleminckx. Christiane C; Schiffers. Bruno B
The study looked at how florists can get pesticide chemicals on their skin while handling flowers, finding many different pesticides on glove samples and some levels that exceed safety limits, especially for a chemical called clofentezine.