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Cathelicidin, hCAP-18, FALL-39, CAP-18
An antimicrobial peptide of the cathelicidin family that provides innate immune defense by killing pathogens and modulating inflammation and wound healing.
Hunold. Katherine M KM; Schwaderer. Andrew A; Stephens. Julie A JA; Wexler. Randell R; Camargo. Carl...
In older adults without urinary symptoms, the antimicrobial peptide LL‑37 (and three other similar peptides) did not show higher levels when harmless bacteria were present in the urine, meaning these peptides aren’t useful for spotting silent infections in this group.
Lindblad. Ylva Tranæus YT; Tóthová. Ľubomíra Ľ; Celec. Peter P; Kubl...
The study looked at kids with chronic kidney disease and found that after a kidney transplant they have more free DNA floating in their blood, which is linked to inflammation markers like IL‑6, the antimicrobial peptide LL‑37, and a bigger heart muscle. The heart size (LVMI) was the strongest factor tied to these DNA levels, but the research doesn’t give any clear steps you can take to change this.
Yamazaki. Emi E; Fujimura. Taku T; Takahashi-Watanabe. Manami M; Amagai. Ryo R; Tamabuchi. Erika E;...
A study of 237 Japanese skin cancer patients showed that squamous cell carcinoma (SCC) arising from hidradenitis suppurativa (HS) on the buttocks is far more likely to recur or spread. The peptide LL‑37, which is higher in HS‑affected skin, seems to help the tumor grow, and a gene called ACTA1 was also found to be increased in these cancers.
Reczyńska-Kolman. Katarzyna K; Ochońska. Dorota D; Brzychczy-Włoch. Monika M; Pamu...
Scientists made tiny fat‑based particles that can carry the antibacterial peptide LL‑37. They figured out how the recipe (type of solvent, amount of surfactant, stearic acid level, and mixing strength) changes the particle size and shape. The particles stayed safe for cells and could kill a common throat‑infection bacteria, suggesting they might be useful for treating infected wounds.
Davis. Sarah E SE; Hart. Meaghan T MT; Braza. Rezia Era D RED; Perry. Aolani A AA; Vega. Luis A LA;...
This study shows that a vitamin B6‑saving system in the bacteria that cause strep throat helps them survive attacks by our immune cells and the natural antibiotic peptide LL‑37. When the bacteria’s B6 pathway is broken, they die more easily in human blood, but the effect isn’t seen in mice. The findings mainly tell us how the bug evades our defenses, not how to use LL‑37 for health.
Adeleye. Samuel A SA; Mechesso. Abraham F AF; Mukherjee. Arpita A; Wang. Guangshun G; Yadavalli. Sru...
Scientists found that the human peptide LL-37 can trigger a bacterial alarm system (PhoQ-PhoP) even at doses that don’t kill the bacteria. This alarm makes the bacteria grow longer and changes how they divide, and it happens through a different mechanism than previously thought.
Zhang. Chuanxi C; Jin. Hui H; Kang. Yumeng Y; Wu. Yiling Y; Zheng. Ruiping R; Zhang. Ziyan Z; Xu. Ho...
In mice, blocking the immune protein IL‑17A with special antibodies reduced skin inflammation and scarring caused by the peptide LL‑37, which is used to mimic rosacea. The study shows a possible way to calm rosacea‑related damage, but it involves prescription‑only antibodies and isn’t a DIY approach.
Li. Yuhang Y; Yuan. Hui H; Cheng. Yi-Lun YL; Li. Qiu-Xia QX; Cao. Rong R; Li. Jin-Lin JL; Yin. Qi Q;...
Scientists created a new cobalt‑based material that can mop up harmful reactive oxygen species and latch onto the peptide LL‑37, which drives psoriasis. In animal tests this material lowered skin inflammation, but it isn’t something you can buy or use right now.
Chen. Sheng-Yuan S-Y; Chang. Che-Kang C-K; Lan. Chung-Yu C-Y
The study shows that the human antimicrobial peptide LL‑37 can damage the cell membrane of the fungus Candida albicans and mess up its calcium balance, doing this through a specific signaling route called the Rim101 pathway. While this reveals how LL‑37 fights fungal infections, it doesn’t give a clear way for everyday health enthusiasts to use the peptide for personal health goals like longevity or performance.
Si. Feifei F; Lu. Yaheng Y; Wen. Yizhou Y; Chen. Tingting T; Zhang. Yingzi Y; Yang. Yanfeng Y
The study found that a protein called LL‑37 is higher in kids with Kawasaki disease and that it makes heart‑lining cells die and release inflammation signals by turning on a TLR4‑NF‑κB‑NLRP3 pathway. Blocking TLR4 reduced these harmful effects, hinting at a possible treatment target for the disease.
Aydın. Umut U; Karataş. Ahmet A; Artaş. Gökhan G; Öz. Burak B; Aydo...
A study of 36 women with a rare breast inflammation called idiopathic granulomatous mastitis found that they have lower blood levels of the antimicrobial peptide LL-37 (and some related immune markers) compared to healthy women. The researchers think this drop might be part of why the disease develops, but they didn’t test any treatments or ways to raise LL-37.
Alrasheed. Abdullah R AR; Awadalla. Maaweya M; Alnajran. Hadeel H; Alammash. Mohammed H MH; Almaqati...
The paper talks about using natural immune proteins like LL-37 as helpers (adjuvants) in vaccines against MERS‑CoV. It lists several human‑derived molecules that could make a vaccine work better, but it doesn’t give any dosing tips or protocols you can try at home.
Elgarhy. Lamia Hamouda LH; Ramadan. Basma Ramadan Refaey BRR; Sallam. Fersan Abd Allah FAA; Iskandar...
The study looked at the levels of the antimicrobial peptide LL‑37 in the skin of people with vitiligo, a condition where skin loses pigment. Researchers found higher LL‑37 in both affected and nearby healthy‑looking skin compared to people without vitiligo, and the amount of LL‑37 was linked to how active the disease was. This suggests LL‑37 might play a role in the disease process, but the work does not test any treatments or give clear advice on how to use LL‑37 for health improvement.
Oliveira. Steffany Bernardo SB; Silveira. Ana Luíza Pereira Assunção ALPA; Kim. Yeon...
A small study looked at how cleaning the gums without surgery affected saliva proteins, including the antimicrobial peptide LL‑37, in people with and without diabetes. After treatment, people without diabetes showed a drop in an inflammation marker (TNF‑α), but diabetics did not see the same benefit and actually had higher TNF‑α. Levels of LL‑37 weren’t reported to change, so the study doesn’t give clear guidance on using this peptide for health.
Zeng. Bijun B; Yang. Zhibo Z; Jiang. Gufen G; Zhou. Hongxia H; Zhang. Yujin Y; Wang. Chang C; Peng....
In mice that were given a peptide (LL‑37) to cause rosacea‑like skin inflammation, a plant‑derived sugar mixture called Dendrobium polysaccharide (DOP) reduced redness, skin damage, and inflammation by blocking a key immune pathway (TLR4/NF‑κB).
Pastuszak. Katarzyna K; Jurak. Małgorzata M; Kowalczyk. Bożena B; Tarasiuk. Jacek J; Wi&...
The study looked at how the human antimicrobial peptide LL‑37 affects the membrane fats of a specific bacteria, Legionella gormanii, and found that the bacteria’s growth conditions (like having extra choline) change how the peptide works, either slipping into the membrane or breaking it apart.
Lou. J J; He. X X
LL-37 is a natural human peptide that scientists have found can kill or slow down parasites in lab studies, so it might someday become an alternative to traditional anti‑parasitic drugs, but there’s no clear recipe or dosage for everyday use yet.
Bing. Jian J; Guan. Zhangyue Z; Zheng. Tianhong T; Ennis. Craig L CL; Nobile. Clarissa J CJ; Chen. C...
The study shows that the fungus Candida auris can quickly change into a clumped‑together form inside mice, especially in the brain, and this clumped form is harder for the body’s natural antimicrobial peptide LL‑37 to kill. The change happens because of new genetic mutations that affect how the fungus grows and divides.
Li. Zhi Z; Wang. Yuhang Y; Yuan. Xingshi X; Xu. Mingyou M; Wang. Xiaofang X; Liu. Chang C; Zhu. Chen...
Scientists made tiny silica particles coated with a short peptide (RGD) that carry the antimicrobial peptide LL‑37. When placed on infected implants, these particles release LL‑37 to kill bacteria and push immune cells toward a more aggressive (M1) state, while the RGD coating helps keep the immune cells alive and reduces a harmful form of cell death called pyroptosis.
Liu. Yijun Y; Zhang. Xuan X; Yang. Silan S; Guo. Qiuyan Q; Zhang. Yuying Y; Wang. Zishu Z; Xu. Shan...
Scientists made a tiny particle that uses the natural antimicrobial peptide LL‑37 to find infected diabetic wounds, then releases enzyme‑based weapons when the wound’s own hyaluronidase breaks down a coating. The particles also heat up with light to help kill bacteria and speed healing, and they worked well in lab tests and mouse models.