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Selanc, TP-7
A synthetic heptapeptide with anxiolytic, neuroprotective, and immunomodulatory effects, modulating neurotransmitter systems without sedative side effects.
Ashmarin. I P IP; Baglikova. K E KE; Edeeva. S E SE; Zolotarev. Iu A IuA; Kozik. V S VS; Dadaian. A...
In rats, the peptide selank reaches the brain best when given through the nose, while it piles up in the stomach no matter how you take it. This means a nasal spray is the most efficient way to get selank’s effects in the central nervous system, and you’ll also get strong exposure to the gut.
Pavlov. T S TS; Samonina. G E GE; Bakaeva. Z V ZV; Zolotarev. Yu A YA; Guseva. A A AA
A study found that Selank, a synthetic peptide usually used for anxiety, also helped protect the stomach lining in animal tests, making ulcers smaller.
Kolik. L G LG; Nadorova. A V AV; Kozlovskaya. M M MM
In a rat study, a single injection of the peptide selank (0.3 mg/kg) stopped the anxiety and pain‑like symptoms that usually appear when the animals stopped drinking alcohol, without changing how much they drank. This points to selank’s potential to ease alcohol‑withdrawal discomfort, but it’s only been shown in animals so far.
Medvedev. V E VE; Tereshchenko. O N ON; Kost. N V NV; Ter-Israelyan. A Yu AY; Gushanskaya. E V EV; C...
Adding the peptide selank to a benzodiazepine (phenazepam) helped patients with anxiety feel better faster and cut down on common side‑effects like memory problems, drowsiness, and sexual issues, which also boosted overall quality of life.
Kozlovskii. I I II; Danchev. N D ND
In a rat study, the synthetic peptide Selank (300 µg/kg) given 15 minutes before learning sessions boosted memory performance, especially in rats that started out with poor learning ability. The benefit showed up after the first dose and got stronger over four days, with the biggest effect in normal rats appearing on day three. The results suggest Selank could help improve memory when you’re stressed, but it’s only been tested in animals so far.
Vyunova. Tatiana V TV; Andreeva. Lioudmila L; Shevchenko. Konstantin K; Myasoedov. Nikolay N
Selank is a tiny protein that can calm anxiety by tweaking the brain's GABA system, similar to how some anti‑anxiety drugs work. It boosts GABA activity in a way that depends on the dose and can change how drugs like diazepam act, sometimes blocking their effects. This suggests Selank might be useful on its own or in combination with other anxiolytics, but the evidence is still early‑stage and mostly from lab experiments.
Zozulya. A A AA; Kost. N V NV; Yu Sokolov. O O; Gabaeva. M V MV; Grivennikov. I A IA; Andreeva. L N...
Selank is a small peptide that can calm anxiety by stopping the breakdown of natural brain chemicals called enkephalins. In people with generalized anxiety, enkephalins break down faster, but Selank blocks the enzymes that do this, and it does so more effectively than some other enzyme blockers. This suggests Selank could be a useful, low‑side‑effect option for anxiety, though exact dosing for everyday use isn’t defined yet.
Ershov. F I FI; Uchakin. P N PN; Uchakina. O N ON; Mezentseva. M V MV; Alekseeva. L A LA; Miasoedov....
The study shows that Selank, a peptide similar to a natural body molecule, can stop flu virus from multiplying in lab cells and helps mice survive flu when taken before they get sick. It works by boosting a key antiviral signal (IFN‑alpha) without raising other inflammation signals. However, the research is only in cells and animals, with no human dosing or safety data yet.
Volkova. Anastasiya A; Shadrina. Maria M; Kolomin. Timur T; Andreeva. Lyudmila L; Limborska. Svetlan...
A study in rats showed that a single dose of Selank changes the activity of many genes linked to the brain's GABA system, similar to what classic anti‑anxiety drugs do. The biggest changes happened an hour after the injection and some lasted for three hours, hinting that Selank may act as an all‑osteric modulator of GABA receptors.
Uchakina. O N ON; Uchakin. P N PN; Miasoedov. N F NF; Andreeva. L A LA; Shcherbenko. V E VE; Mezents...
Selank, a small brain‑active peptide, appears to change immune signaling in people with anxiety or depression, lowering certain inflammatory gene activity while boosting protein levels, and it shifts the balance of immune helper cells after two weeks of use. This hints it could help manage stress‑related immune issues, but the study doesn’t give clear dosing or practical guidelines.
Semenova. T P TP; kozlovskiĭ. I I II; Zakharova. N M NM; Kozlovskaia. M M MM
In rats whose brain serotonin was artificially lowered, a single dose of the peptide selank quickly boosted serotonin activity in the brain stem, while a similar peptide, tuftsin, did not help and even reduced activity in the cortex.
Kozlovskiĭ. I I II; Belozertsev. Iu F IuF; Semenova. T P TP; Zuĭkov. A V AV; Kozlovskaia...
In rats, the peptide Selank helped restore learning and memory that were messed up by damaging the brain's norepinephrine system, either with chemicals or low‑oxygen conditions. It seems to work by boosting the brain's drive to search for solutions early in a learning task and by improving how memories are stored and recalled later.
Giving the peptide Selank through the nose to monkeys made them less fearful and aggressive, more curious, and helped them handle stress and memory problems better over the long term.
Zozulia. A A AA; Neznamov. G G GG; Siuniakov. T S TS; Kost. N V NV; Gabaeva. M V MV; Sokolov. O Iu O...
In a small clinical trial, the peptide selank lowered anxiety about as well as the benzodiazepine medazepam, but it also helped reduce fatigue and gave a mild boost in energy. The researchers saw that patients with anxiety had low blood levels of a natural pain‑relief molecule (leu‑enkephalin), and selank treatment raised those levels, especially in the anxiety group.
Sarkisova. K Iu KIu; Kozlovskiĭ. I I II; Kozlovskaia. M M MM
In animal tests, the peptide selank showed signs of reducing depression‑like behavior. A single low dose helped mice swim longer before giving up, while repeated higher doses helped a rat strain that naturally shows depressive traits. It didn’t change overall activity or anxiety, and it didn’t affect normal rats.
Kozlovskiĭ. I I II; Danchev. N D ND
In a rat study, the synthetic peptide Selank helped animals learn faster, especially those that initially struggled, and the benefit grew with daily doses before training. It also reduced mistakes and seemed to work better after a few days, showing promise for boosting memory under stress, but the research is only in animals.
Kolomin. T A TA; Agapova. T Iu TIu; Agniullin. Ia V IaV; Shram. S I SI; Shadrina. M I MI; Slominski&...
A study in rats found that a single or short course of the peptide Selank, given through the nose, changes the activity of dozens of genes in the brain area important for memory. Many of these genes are linked to cell membrane proteins, hinting that Selank might help balance ions in brain cells, which could affect learning and memory processes.
Konstantinopolsky. M A MA; Chernyakova. I V IV; Kolik. L G LG
In rats that were dependent on morphine, a single low dose of the peptide Selank (0.3 mg/kg) reduced overall withdrawal symptoms by about 40%, cut down convulsions, eye drooping, and posture problems, and made the animals far less sensitive to touch. Its effects were a bit weaker than a standard anti‑anxiety drug, diazepam, but still clearly helped with withdrawal signs.
Solov'ev. V B VB; Gengin. M T MT; Sollertinskaia. T N TN; Latynova. I V IV; Zhivaeva. L V LV
A single dose of selank changes the activity of two brain enzymes that control the breakdown of certain neuropeptides, and these changes last for about a day. This suggests selank might influence how long neuropeptides stay active in the brain.
Mukhina. A Yu AY; Mishina. E S ES; Bobyntsev. I I II; Medvedeva. O A OA; Svishcheva. M V MV; Kalutsk...
In stressed rats, the gut lining gets damaged and stress hormones go up. Giving the peptide Selank before stress lowered the stress hormone corticosterone, reduced gut damage, and helped the animals adapt faster. The study was done in rats with injections, not humans.