A synthetic heptapeptide with anxiolytic, neuroprotective, and immunomodulatory effects, modulating neurotransmitter systems without sedative side effects.
Medvedev. V E VE; Tereshchenko. O N ON; Israelian. A Iu AIu; Chobanu. I K IK; Kost. N V NV; Sokolov....
A study with 60 people who have anxiety disorders found that the peptide selank reduced anxiety and gave a mild boost to thinking abilities. The calming effect lasted about a week after the last dose, and patients reported a better overall quality of life. Selank was also well‑tolerated compared with the traditional drug phenazepam.
Ashmarin. I P IP; Bakaeva. Z V ZV; Vas'kovskiĭ. B V BV; Zheliaznik. N Ia NIa; Zhuĭkova....
Researchers found that a new group of tiny proteins called glyprolines are very stable, can get into the bloodstream when taken by mouth, and showed promising anti‑ulcer, blood‑clot‑preventing, and blood‑sugar‑lowering effects in rats. They think these peptides could become drugs for stomach ulcers, clot disorders, and diabetes, but they’re still in early animal testing.
Semenova. T P TP; Kozlovskiĭ. I I II; Zakharova. N M NM; Kozlovskaia. M M MM
In rats, a single injection of the peptide selank right after a learning session boosted serotonin activity in the brain and made the memory of that session last much longer—up to a month. The effect was seen when selank was given at a dose of 300 µg per kilogram of body weight.
Fomenko. E V EV; Bobyntsev. I I II; Kryukov. A A AA; Ivanov. A V AV; Andreeva. L A LA; Myasoedov. N...
In rats, giving Selank before stressful situations lowered some liver stress markers and boosted overall antioxidant activity, especially at lower doses. The highest dose also lowered blood enzymes that signal liver damage. These effects were seen both in short‑term and long‑term stress, but the study used injections that aren’t typical for humans.
A lab test using a blood‑clotting analyzer showed that Selank and two similar short peptides make blood clot less easily, with Selank having the strongest effect. The study measured several clot‑formation numbers that all shifted toward thinner clotting compared to normal blood.
Kolomin. Timur T; Shadrina. Maria M; Andreeva. Lyudmila L; Slominsky. Petr P; Limborska. Svetlana S;...
A single injection of the peptide Selank in mice changed the activity of many genes that control inflammation, especially the Bcl6 gene, which is important for the immune system. Both the whole peptide and its smaller pieces caused these changes, showing Selank can influence immune‑related gene activity, but the study was done only in mice and looked at gene levels, not actual health effects.
Semenova. T P TP; Kozlovskaya. M M MM; Zuikov. A V AV; Kozlovskii. I I II; Zakharova. N M NM; Andree...
In a rat study, giving the peptide Selank after birth helped fix brain chemistry and boost attention and learning that were damaged by low oxygen during pregnancy. The drug balanced serotonin and norepinephrine levels and made the animals behave more normally in tests of curiosity and focus.
Fomenko. E V EV; Bobyntsev. I I II; Ivanov. A V AV; Belykh. A E AE; Andreeva. L A LA; Myasoedov. N F...
In rats that were repeatedly shocked, a stress‑inducing situation damaged their liver cells. Giving the peptide Selank before each shock reduced the damage, especially at a middle dose (300 µg/kg). The study suggests Selank might protect the liver from stress‑related harm, but it’s an animal experiment and the dosing method isn’t how people normally take it.
Wachter. Rolf R; Lahno. Rosine R; Haase. Beatrice B; Weber-Krüger. Mark M; Seegers. Joachim J;...
The study shows that higher levels of the heart‑related peptide BNP (and to a lesser extent NT‑proBNP) on hospital admission can flag patients with a hidden, intermittent form of atrial fibrillation after a stroke, helping doctors decide who should get longer heart‑monitoring. This isn’t a new treatment, but it gives a simple blood test clue for spotting a risky heart rhythm that could affect overall health and longevity.
The paper reviews several GABA‑acting sedatives, noting that selank – a Russian peptide sold as a supplement – is barely studied and may have abuse and withdrawal risks similar to phenibut, while high‑dose GABA drugs can cause serious breathing problems and death.
Filatova. Elena E; Kasian. Anastasiya A; Kolomin. Timur T; Rybalkina. Ekaterina E; Alieva. Anelya A;...
In a lab study using human neuroblastoma cells, the peptide Selank didn’t change the activity of genes that control the GABA system on its own. However, when mixed with GABA it blocked GABA‑induced gene changes, and when mixed with the antipsychotic drug olanzapine it amplified gene changes compared to olanzapine alone. This suggests Selank can influence how GABA and certain drugs affect brain cells, but the work was done in cells, not people.
Mukhina. A Yu AY; Medvedeva. O A OA; Svishcheva. M V MV; Shevchenko. A V AV; Efremova. N N NN; Bobyn...
In rats, stress messed up the gut bacteria, lowering the good ones and letting bad ones grow, but giving Selank before the stress helped keep the good bacteria and stop the bad ones from taking over.
Penčić-Popović. Biljana B; Ćelić. Vera V; Ćosić. Zoran Z;...
People who are at a slightly higher risk of developing type 2 diabetes show weaker heart‑rate variability (HRV), especially during the day. This means their autonomic nervous system isn’t working as well, which could be an early warning sign before blood sugar problems appear.
Kolik. L G LG; Nadorova. A V AV; Antipova. T A TA; Kruglov. S V SV; Kudrin. V S VS; Durnev. A D AD
In a rat study, a short 7‑day course of the peptide Selank (given by injection) helped normal rats think better and stopped memory problems caused by long‑term heavy drinking. The drug also kept levels of a brain protein called BDNF from rising too much in key brain areas.
Kozlovskaya. M M MM; Kozlovskii. I I II; Val'dman. E A EA; Seredenin. S B SB
In rats and mice, the peptide Selank and several related short peptides reduced stress‑related behavior, showing calming and anti‑stress effects. Different peptide structures gave slightly different results, suggesting they can be tweaked for specific outcomes. The authors say these peptides appear safe in animals and could be designed for predictable effects.
Zolotarev. Iu A IuA; Sokolov. O Iu OIu; Kost. N V NV; Vas'kovskiĭ. B V BV; Miasoedov. N F NF;...
The study shows that Selank, a peptide some people use for mood and stress, can block certain enzymes (carboxypeptidases) that break down the natural pain‑relief molecule Leu‑enkephalin in blood plasma. This suggests Selank might help keep enkephalins around longer, but the work was done in a test‑tube setting, not in people, and it doesn’t tell you how much to take or what effects to expect.
Sokolov. O Yu OY; Meshavkin. V K VK; Kost. N V NV; Zozulya. A A AA
In a mouse study, the peptide Selank lowered anxiety and slowed the breakdown of a natural pain‑relief molecule (leu‑enkephalin) in one strain of mice (BALB/c) but did nothing in another strain (C57Bl/6). This suggests Selank’s calming effect may come from blocking enzymes that destroy enkephalins, but the results are limited to mice and depend on genetic background.
Kolomin. Timur T; Morozova. Marina M; Volkova. Anastasiya A; Shadrina. Maria M; Andreeva. Lyudmila L...
A single injection of the peptide Selank (and its tiny piece Gly‑Pro) quickly lowered the activity of several genes that control inflammation in mouse spleen, showing a short‑term anti‑inflammatory effect.
Vasil'eva. E V EV; Kondrakhin. E A EA; Salimov. R M RM; Kovalev. G I GI
In mice, the anxiety‑reducing and memory‑boosting peptide selank worked only in a strain that was naturally more anxious, and the way it was given mattered: a belly‑injection boosted GABA receptors in the brain, while a nose‑spray boosted NMDA receptors. The effects didn’t show up in the less‑anxious mouse strain.
Kozlovskiĭ. I I II; Belozertsev. F Iu FIu; Andreeva. L A LA; Kozlovskaia. M M MM
In a rat study, the peptide selank helped protect memory and learning when the animals were given a drug that blocks protein production, which normally messes up their ability to learn a maze. Selank reduced the time it took the rats to learn and helped them relearn when the maze changed, showing a protective effect on memory processes.