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Thymosin-alpha-1

Thymalfasin, Zadaxin, Thymosin α1

A synthetic 28-amino acid peptide that enhances immune function by modulating T-cell activity, used for viral infections and immunodeficiencies.

Quick Stats
Studies 759
Trials 63
Formula C129H215N33O55
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Utility 1
pubmed 1988

Immunolocalization of thymosin alpha 1, thymopoietin and thymulin in mouse thymic epithelial cells at different stages of culture: a light and electron microscopic study.

Fabien. N N; Auger. C C; Monier. J C JC

This study looked at mouse thymus cells grown in a dish and tracked where three thymus‑derived hormones (thymosin‑alpha‑1, thymulin, and thymopoietin) are made and released over time. It found that the number of cells making these hormones rises between days 6 and 12, and that the hormones shift from being stored in small granules early on to being spread throughout the cell later.

pubmed Nov 24, 2022

A randomized controlled pilot trial of etanercept and alpha-1 antitrypsin to improve autologous islet engraftment.

Abdel-Karim. Tasneem R TR; Hodges. James S JS; Pruett. Timothy L TL; Ramanathan. Karthik V KV; Herin...

This small trial looked at two anti‑inflammatory drugs, etanercept and alpha‑1‑antitrypsin, to see if they help transplanted pancreatic islets survive better after total pancreatectomy. The study has nothing to do with thymosin‑alpha‑1 and focuses on a very specific surgical context, so it offers no practical guidance for biohackers or anyone looking to use peptides for general health or longevity.

pubmed Dec 1, 2020

A Convalescent of COVID-19 with RT-PCR Test Continues Positive in Stool.

Yang. Zhiwei Z; Yu. Mingxue M; Li. Ganwen G; Dai. Xiaoling X; Liu. Guirong G; Xie. Jinjun J; Li. Gan...

This study reports a COVID‑19 patient whose nose/throat tests turned negative, but the virus’s genetic material was still found in stool 24 days later, suggesting the gut can keep shedding virus after respiratory recovery.

pubmed 2017

Enhancing Survival of Human Hepatocytes by Neonatal Thymectomy and Partial Hepatectomy in Micro-miniature Pigs.

Hsu. H C HC; Enosawa. S S; Yamazaki. T T; Tohyama. S S; Fujita. J J; Fukuda. K K; Kobayashi. E E

Researchers removed the thymus from newborn mini-pigs and later gave them human liver cells. The pigs without a thymus showed lower levels of the peptide thymosin‑alpha‑1 and, when a part of the liver was also removed, the human liver cells grew better, as shown by human albumin in the blood. This work is an animal study and does not give a direct way for people to use thymosin‑alpha‑1 for health benefits.

pubmed Aug 31, 2011

Top-down label-free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers.

Maltman. Daniel J DJ; Brand. Sven S; Belau. Eckhard E; Paape. Rainer R; Suckau. Detlev D; Przyborski...

The study examined tiny proteins in brain stem cells and found that thymosin‑alpha‑1 is present among many other structural proteins, but it only describes basic cell biology and does not give any health‑related advice or dosing information.

pubmed Aug 29, 2012

Treatment of chronic delta hepatitis.

Yurdaydin. Cihan C

The paper reviews treatments for chronic delta hepatitis and finds that only interferon (standard or pegylated) works modestly, helping about a quarter of patients, while other drugs like nucleos(t)ide analogs don’t help. It doesn’t discuss thymosin‑alpha‑1 or give any new, DIY‑friendly tips.

pubmed May 14, 2000

Quantitative analysis of thymosin alpha1 in human serum by LC-MS/MS.

Tuthill. C W CW; Rudolph. A A; Li. Y Y; Tan. B B; Fitzgerald. T J TJ; Beck. S R SR; Li. Y X YX

The paper only explains a lab technique for measuring thymosin‑alpha‑1 levels in blood, without any information on how to use the peptide for health or performance.

pubmed 2004

[Recombinant thymosin alpha1].

Esipov. R S RS; Gurevich. A I AI; Stepanenko. V N VN; Chupova. L A LA; Chuvikovskiĭ. D V DV; M...

The paper explains a lab technique for making thymosin‑alpha‑1 in bacteria using genetic engineering, but it doesn’t test the peptide’s health effects or give dosing advice, so it isn’t directly useful for everyday biohacking or self‑experimentation.

pubmed 2004

Retreatment of patients who do not respond to initial therapy for chronic hepatitis C.

Shiffman. Mitchell L ML

This study looked at people with chronic hepatitis C who didn’t get better with the first round of treatment and tried giving them more pegylated interferon and ribavirin. It found that only a tiny fraction of these hard‑to‑treat patients actually cleared the virus, and there’s no proven way to help those who fail even this second round. The peptide thymosin‑alpha‑1 isn’t mentioned, so the findings don’t give any new tips for using it.

pubmed 1995

Thymosin alpha-1 and FA-1 monoclonal antibody affect fertilizing capacity of human sperm by modulating protein phosphorylation pattern.

Ahmad. K K; Naz. R K RK

The study shows that the peptide thymosin‑alpha‑1 can change the way certain proteins on human sperm are phosphorylated, which improves the sperm's ability to penetrate an egg, while an antibody against a related protein blocks this effect. This effect is specific to sperm function and does not translate to general health or performance benefits.

pubmed Apr 1, 2000

Antiviral therapy of HBV- and HCV-induced liver cirrhosis.

Zavaglia. C C; Airoldi. A A; Pinzello. G G

The abstract reviews current antiviral treatments for liver cirrhosis caused by hepatitis B and C, focusing on interferon‑alpha, lamivudine, ribavirin and other drugs, and highlights that results are modest and more research is needed. It does not mention thymosin‑alpha‑1 or give any direct, actionable advice for self‑experimenters.

pubmed Sep 20, 1996

Electrophysical monitoring of culture process of recombinant Escherichia coli strains.

Bunin. V D VD; Voloshin. A G AG; Bunina. Z F ZF; Shmelev. A V AV

The paper describes a lab technique for watching how engineered E. coli bacteria grow while they make a fusion protein that includes thymosin‑alpha‑1, but it doesn’t give any advice on using the peptide in humans or suggest new health‑boosting protocols.

pubmed 1995

Thymosin alpha-1 and FA-1 monoclonal antibody affect murine preimplantation embryo development by modulating protein phosphorylation.

Ahmad. K K; Naz. R K RK

The study looked at how the peptide thymosin‑alpha‑1 affects early mouse embryos grown in the lab. It found that tiny amounts of the peptide helped embryos develop better, while a specific antibody blocked that benefit. The work is basic science about mouse embryo cells and doesn’t give direct advice for human health, longevity, or performance.

pubmed 1996

Development of specific anti-thymosin beta 10 antipeptide antibodies for application in immunochemical techniques.

Leondiadis. L L; Livaniou. E E; Vassiliadou. I I; Ferderigos. N N; Ithakissios. D S DS; Evangelatos....

The paper describes how scientists created very specific antibodies that recognize the peptide thymosin beta‑10, a molecule different from the health‑focused peptide thymosin‑alpha‑1, and shows which tiny piece of the protein works best for making those antibodies. It doesn’t give any advice on using thymosin‑alpha‑1 for longevity, metabolism, or performance.

pubmed Jun 1, 1996

Thymic carcinoma of the thyroid.

Watanabe. I I; Tezuka. F F; Yamaguchi. M M; Sagawa. J J; Kaise. N N

This paper describes a single, rare case of a thyroid tumor that looks like a thymic (thymus) cancer and mentions that the tumor fluid had a lot of the peptide thymosin‑alpha‑1, but it does not test the peptide as a treatment or give any health advice.

pubmed Jul 1, 1995

Local excision of retinal metastasis from cutaneous melanoma.

Balestrazzi. E E; Blasi. M A MA; Marullo. M M; Greco. I M IM; Spadea. L L

This paper describes a rare case where a skin cancer spread to the retina and was removed by surgery. It doesn’t discuss thymosin‑alpha‑1 or any health‑boosting protocol, so it isn’t useful for biohackers looking for actionable tips on longevity or performance.

pubmed 1991

Production of a nef-specific monoclonal antibody by the use of a synthetic peptide.

De Santis. R R; Anastasi. A M AM; Marcolini. S S; Valesini. G G; Pezzella. M M; Vonesch. N N; Sturch...

Scientists created a lab antibody that targets a tiny piece of the HIV protein Nef, which looks similar to the natural peptide thymosin‑alpha‑1, but the work is purely for research and doesn’t give any new health or performance advice.