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Emideltide, DSIP nonapeptide, Delta sleep-inducing peptide
A neuropeptide that induces delta sleep, reduces stress, modulates hormone release, and exhibits antioxidant effects in various physiological processes.
Mendzheritskii. A M AM; Lysenko. A V AV; Uskova. N I NI; Sametskii. E A EA
In rats, a specific dose of the peptide delta‑sleep‑inducing peptide (DSIP) helped protect the brain when the animals were exposed to very high oxygen levels. The peptide slowed down seizure onset and helped the animals return to normal sleep patterns within a day.
Späth-Schwalbe. E E; Schäfer. A A; Uthgenannt. D D; Born. J J; Fehm. H L HL
A small study in healthy young men found that giving delta‑sleep‑inducing peptide (DSIP) does not change the body’s release of stress hormones (ACTH and cortisol) after a CRH challenge or after a meal. In other words, DSIP didn’t blunt the normal hormone spikes you’d expect from these triggers.
Vgontzas. A N AN; Friedman. T C TC; Chrousos. G P GP; Bixler. E O EO; Vela-Bueno. A A; Kales. A A
A small study measured the natural levels of the sleep‑related peptide DSIP in people with sleep apnea, narcolepsy, and healthy volunteers. It found no clear differences between the groups, though narcoleptic patients not on medication tended to have slightly lower levels. Overall, the results suggest that a single blood test for DSIP isn’t useful for diagnosing or tracking these sleep disorders.
Friedman. T C TC; Garcia-Borreguero. D D; Hardwick. D D; Akuete. C N CN; Stambuk. M K MK; Dorn. L D...
The study measured a natural sleep‑related peptide called DSIP in the blood of healthy people over a full day. It found that DSIP levels rise during the day, peak around 3 PM, and are lowest around 1 AM, matching the body‑temperature cycle. Surprisingly, DSIP levels drop during deep (slow‑wave) sleep and REM sleep, and they don’t increase right before or during deep‑sleep episodes.
Koplik. E V EV; Sudakov. K V KV
In rats, damaging key brain areas that control emotions (the septum and amygdala) makes them far less able to handle stress. Giving them a peptide called delta‑sleep‑inducing peptide (DSIP) at a specific dose helped bring back some of that lost stress resistance, improving their behavior, survival, and stress‑related organ changes.
Khaspekov. L G LG; Klyushnik. T P TP; Dupin. A M AM; Lyzhin. A A AA; Bezrukov. M V MV
A product called Biolan, which mixes the amino‑acid carnosine with the delta sleep‑inducing peptide (DSIP), was shown to protect young rat brain cells in a dish from damage caused by lack of oxygen/glucose and from excess glutamate.
Bondarenko. T I TI; Milyutina. N P NP; Shustanova. T A TA; Mikhaleva. I I II
In rats, giving delta sleep‑inducing peptide (DSIP) before a three‑day cold stress lowered signs of oxidative damage and the activity of an enzyme linked to stress, especially in the liver and brain. In normal rats, DSIP didn't change that enzyme's activity but still reduced some markers of lipid damage.
García-Borreguero. D D; Wehr. T A TA; Larrosa. O O; Granizo. J J JJ; Hardwick. D D; Chrousos. G...
In people with Addison's disease (no natural cortisol), taking a dose of hydrocortisone at night helped them fall into REM sleep faster and spend more time in REM, without changing total sleep length. This suggests cortisol can boost REM sleep and make sleep more consolidated, likely through brain pathways that involve stress hormones.
Shandra. A A AA; Godlevskii. L S LS; Brusentsov. A I AI; Vast'yanov. R S RS; Karlyuga. V A VA; Dzyga...
In a rat study, a peptide called delta‑sleep‑inducing peptide (DSIP) helped protect the brain after a stroke‑like injury. The treated rats showed fewer movement problems and fewer deaths within a day, and DSIP worked even better than a known neuroprotective drug (MK‑801). The researchers think this could point to DSIP as a future stroke treatment, but it’s still early‑stage animal work.
Shandra. A A AA; Godlevskii. L S LS; Brusentsov. A I AI; Karlyuga. V A VA
In rats, giving delta‑sleep‑inducing peptide (DSIP) made the brain much less likely to seize when exposed to a chemical (NMDA) that normally triggers convulsions. The peptide raised the amount of NMDA needed to cause two types of seizures by about 2‑ to 4‑fold, hinting that DSIP could protect nerve cells from over‑excitation.
Nakamura. A A; Nakanishi. H H; Shiomi. H H
The study shows that the brain naturally releases delta sleep‑inducing peptide (DSIP) when nerve cells fire, and that the peptide is quickly broken down by specific enzymes on cell membranes. This release doesn’t need calcium, which makes it different from many other brain chemicals.
Yehuda. S S; Mostofsky. D I DI
In a rat study, giving DSIP (the same peptide some biohackers use) changed how easily the animals had seizures, and the effect depended on the time of day. At night DSIP raised the seizure threshold (making seizures less likely), while during the day it didn’t help and even made the animals slightly more vulnerable compared to a saline control. The researchers think dopamine may be involved in this time‑dependent effect.
Bes. F F; Hofman. W W; Schuur. J J; Van Boxtel. C C
In a small study of 16 people with chronic insomnia, giving a short IV dose of delta sleep‑inducing peptide (DSIP) slightly improved how quickly they fell asleep and how efficiently they slept, but the changes were weak and didn’t make people feel better about their sleep overall.
Ouichou. A A; Pévet. P P
In rat pineal gland experiments, the peptide DSIP was found to raise melatonin levels, but it does this by breaking down into the amino acid tryptophan, which then drives melatonin production. The effect disappears when the breakdown process is blocked, showing DSIP works like a tryptophan source rather than directly stimulating melatonin.
Vallet. P G PG; Charnay. Y Y; Boura. C C; Kiss. J Z JZ
In rats, the sleep‑related peptide DSIP and the hormone‑releasing peptide LH‑RH are packed together in the same nerve endings in the brain area that controls hormone release. This means they are likely released at the same time, hinting that DSIP could influence reproductive hormone signaling.
Nakamura. A A; Sakai. K K; Takahashi. Y Y; Shiomi. H H
In rat brain tissue, the peptide DSIP caused nerve endings to let in calcium and release the natural opioid Met‑enkephalin, but only in certain brain regions. This effect was seen at very low concentrations and did not happen in the striatum.
Chiodera. P P; Volpi. R R; Capretti. L L; Giacalone. G G; Caffarri. G G; Davoli. C C; Nigro. E E; Co...
A short infusion of the peptide delta‑sleep‑inducing peptide (DSIP) in healthy young men lowered the stress‑related hormone ACTH, but it didn’t change the water‑balance hormone AVP, even when the body was challenged with salty water or standing up. In other words, DSIP can blunt ACTH spikes but doesn’t seem to affect the body’s normal AVP response.
Gray. R A RA; Vander Velde. D G DG; Burke. C J CJ; Manning. M C MC; Middaugh. C R CR; Borchardt. R T...
Scientists studied the tiny sleep‑inducing peptide DSIP and found that, even though it’s water‑loving and charged, it can still slip through the blood‑brain barrier. In solution it flips between a loose shape and more folded turns, with about 40% of the molecules forming beta‑turns, and it becomes more helix‑like in certain solvents.
Bjartell. A A; Sundler. F F; Ekman. R R
The study shows that removing the adrenal glands in rats causes a temporary rise in the natural levels of delta sleep‑inducing peptide (DSIP) in the blood and pituitary, suggesting DSIP is linked to the stress‑hormone system.
Shandra. A A AA; Godlevskii. L S LS; Mazarati. A M AM; Oleshko. A A AA; Mikhaleva. I I II
The study shows that the peptide delta‑sleep‑inducing peptide (DSIP) can reduce seizure‑like activity in several animal tests, especially by acting on a part of the brain called the substantia nigra. However, the work is all in cats, rats and mice, and it doesn’t give any dosing or safety info for people.