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Thymalin

Thymulin, Thymic Factor, Serum Thymic Factor, Facteur Thymique Serique

A synthetic thymic nonapeptide that modulates immune function by promoting T-cell differentiation and enhancing overall immunity.

Quick Stats
Studies 202
Trials 37
Formula C33H54N12O15
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Utility 2
pubmed 1998

[The neurotropic activity of peptide immunomodulators].

Grechko. A T AT

In a short animal test, the peptide thymalin changed how rats moved and slept, acting like a brain‑boosting drug, though it wasn’t the strongest of the compounds tested. The study only used rats and didn’t give dosing details for people, so the results are a hint, not a recipe.

Utility 2
pubmed 1997

[Galvanization of the area of the spleen as a method of immunocorrection in patients with chronic bronchitis].

Siurin. S A SA

A small study compared a physical treatment called spleen galvanization to the peptide thymalin in people with chronic bronchitis. Both methods improved immune cell counts, especially low T‑cells, and worked about as well as each other, better than doing rehab alone. The results suggest thymalin can boost immunity, but the evidence is limited to a specific lung condition and doesn’t give dosing or broader health guidance.

Utility 2
pubmed 1996

[Immunological indicators in children with laryngeal papillomatosis and possible ways of immunocorrection].

Garashchenko. T I TI; Markova. T P TP; Chuvirov. D G DG

The study looked at kids with a throat condition called laryngeal papillomatosis and found their immune systems were weak. Adding the peptide thymalin (along with other drugs) to the treatment made the standard therapy shorter and kept the disease away for a longer time, about 2.5‑3 times longer than usual.

Utility 2
pubmed 1995

[Immunological and nonspecific reactivity in patients with infiltrative pulmonary tuberculosis associated with chronic nonspecific lung diseases].

Morozova. T I TI; Khudzik. L B LB; Rebrov. A P AP

The study found that giving patients with lung tuberculosis an aerosol spray containing the peptide thymalin (along with other protease inhibitors) helped improve their immune system markers and supported the main TB treatment, but the research is limited to sick patients and not directly aimed at healthy people looking to boost performance.

Utility 2
pubmed 1997

[Effect of various chemotherapy regimens on survival and cause of death in patients with multiple myeloma (retrospective study)].

Abdulkadyrov. K M KM; Bessmel'tsev. S S SS; Stel'mashenko. L V LV; Shmidt. A V AV; Rukavitsyn. O A O...

In a look‑back study of 109 multiple‑myeloma patients, those who got a mix of chemo drugs lived longer (average 43 vs 27 months) and, when they also received immune‑boosting drugs like thymalin, infections dropped from about 22% to 8%. The authors say good hydration, detox steps and immune support are important alongside chemo.

Utility 2
pubmed 2001

[Changes in the immune status parameters and their correction in various forms of tick-borne encephalitis].

Krylova. N V NV; Iakusheva. S S SS; Borisevich. V G VG; Leonova. G N GN

The study looked at how the immune system is affected in different forms of tick‑borne encephalitis and tested whether thymalin and a couple of other compounds could boost immune activity in blood samples. They found that thymalin helped increase immune markers only in patients whose immune system was weakened, but it did nothing in people with normal immunity. The effect was modest and only shown in a lab setting, not in healthy volunteers.

Utility 2
pubmed 1996

[Evaluation of the effectiveness of immunomodulators in the treatment of patients with postoperative suppurative-septic complications].

Bulava. G V GV; Nikulina. V P VP

The study tested thymalin and other immune‑boosting drugs in patients who had serious infections after surgery. Thymalin only raised T‑cell numbers when it was given together with antibody‑rich treatments like immunoglobulins or plasma, while other drugs worked more on their own. The results were seen in very sick patients, not healthy people, so the findings are only a hint, not a ready‑to‑use plan for everyday biohackers.

Utility 2
pubmed 1993

[The effect of thymalin on the development of sensitization with a soluble microbial antigen and on the phenotypic composition of lymphocyte subpopulations in the organs of immunity].

Sukhodoeva. G S GS; Shamsutdinova. G S GS; Dobritsa. V P VP; Ospanova. E N EN; Lukpanova. Sh Z ShZ

In guinea pigs, the peptide thymalin boosted the body’s allergic response to a bacterial antigen and changed the mix of immune cells, especially increasing T‑ and B‑lymphocytes. Giving several doses made the effect stronger than a single dose, and the animals could also develop an allergy to thymalin itself.

Utility 2
pubmed 1991

[Use of T-activin and thymalin in the treatment of ophthalmic herpes].

Mal'khanov. V B VB; Gripas'. I A IA; Nasibullina. G Kh GKh; Belousova. M A MA

A study on 80 people with eye herpes found that thymalin (a thymic hormone) and a related peptide called T‑activin helped treat the infection, especially when it lasts a long time. The researchers suggest checking immune markers like neutrophil damage and secretory IgA in tears to see how well the treatment works.

Utility 2
pubmed 1996

[Cytokine production during the development and correction of an immunodeficiency in experimental tuberculosis].

Zabolotnykh. N V NV; Aleksandrova. A E AE; Prokop'eva. E D ED; Pigareva. N V NV

In mice with tuberculosis, the disease lowered a key immune signal (IL‑2) and raised another (IL‑6). Giving standard antibiotics changed some of these signals, and adding an immune‑boosting treatment (likely thymalin) helped bring IL‑2 back up and further increased IL‑6 in certain immune cells. This shows the treatment can partly restore immune balance after infection, but the work was done in mice and not directly tested in people.

Utility 2
pubmed 1994

[Thymalin in the treatment of herpetic stomatitis in children].

Kazantseva. I A IA; Bikbulatov. R M RM

Thymalin, a peptide taken from cow thymus, was given to 44 kids with cold‑sore‑type mouth sores. It didn’t make the sores go away faster, but it seemed to lower the chance of the sores coming back later.

Utility 2
pubmed 1991

[The effect of combined therapy with the use of thymalin and piracetam on the level of middle-molecule peptides in the blood and on the lipid peroxidation activity in patients with diffuse toxic goiter].

Iangolenko. V V VV

The study looked at people with an overactive thyroid (diffuse toxic goiter) and tested different drug combos, including a peptide called thymalin. Adding thymalin together with the usual medicine (mercazolyl) and a brain‑boosting drug (piracetam) lowered harmful blood markers and improved the disease more than the other treatments. However, the research was done on sick patients using prescription drugs, so it isn’t a simple DIY protocol for healthy biohackers.

Utility 2
pubmed 1990

[The effect of thymalin on biochemical and immunological indices of lymphocyte differentiation and functional activity].

Khavinson. V Kh VKh; Kozhemiakin. A L AL; Morozov. V G VG; Kozhemiakin. L A LA

The study shows that the thymus‑derived peptide thymalin can help fix certain enzyme imbalances in immune cells and boost the activity of T‑cells in people with severe immune deficiency, leading to better health signs. However, the research was done in AIDS patients, not healthy volunteers, so its direct use for everyday performance or longevity is uncertain.